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Literature summary extracted from

  • Carrasco, M.A.; Figueroa, S.
    Inositol 1,4,5-trisphosphate 3-kinase activity in frog skeletal muscle (1995), Comp. Biochem. Physiol. B, 110, 747-753.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.127 2,3-diphosphoglycerate
-
 Calyptocephallela gayi
2.7.1.127 CdCl2
-
 Calyptocephallela gayi
2.7.1.127 vanadate
-
 Calyptocephallela gayi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.127 0.0016
-
 1D-myo-inositol 1,4,5-trisphosphate 25°C Calyptocephallela gayi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.127 soluble predominantly Calyptocephallela gayi
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Ca2+ at physiological concentrations Calyptocephallela gayi
2.7.1.127 Ca2+ activation by Ca2+/calmodulin Calyptocephallela gayi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Calyptocephallela gayi important alternative route for inositol 1,4,5-trisphosphate metabolism in skeletal muscle ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Calyptocephallela gayi
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 skeletal muscle
-
 Calyptocephallela gayi
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.127 additional information
-
-
 Calyptocephallela gayi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Calyptocephallela gayi ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate important alternative route for inositol 1,4,5-trisphosphate metabolism in skeletal muscle Calyptocephallela gayi ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.127 8
-
 around Calyptocephallela gayi

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.127 6 8 steep increase in activity on raising pH from pH 6 to an optimum around pH 8 Calyptocephallela gayi

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
 Calyptocephallela gayi
2.7.1.127 Calmodulin activation by Ca2+/calmodulin Calyptocephallela gayi