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Literature summary extracted from

  • Collin, T.
    Serotonin induces an increase in D-myo-inositol (1,4,5)-trisphosphate 3-kinase activity in rat brainstem slices (1998), Neurosci. Lett., 255, 67-70.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.127 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane 5-HT2 agonist DOI, 3fold activation Rattus norvegicus
2.7.1.127 5-HT 2-3fold activation Rattus norvegicus
2.7.1.127 serotonin potentiates enzyme activity mediated through the activation of 5-HT2 receptors, enzyme up-regulation occurs through activation of PLC-coupled serotoninergic receptors and requires the phosphorylation of the enzyme by the ubiquitous multimeric protein kinase CaMKII Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus enzyme occupies a central position in inositol phosphate metabolism by terminating the Ca2+ mobilizing of InsP3 and by generating InsP4 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Rattus norvegicus
-
 adult
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 brain stem
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate enzyme occupies a central position in inositol phosphate metabolism by terminating the Ca2+ mobilizing of InsP3 and by generating InsP4 Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.127 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
 Rattus norvegicus