Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Biden, T.J.; Comte, M.; Cox, J.A.; Wollheim, C.B.
    Calcium-calmodulin stimulates inositol 1,4,5-trisphosphate kinase activity from insulin-secreting RINm5F cells (1987), J. Biol. Chem., 262, 9437-9440.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.127 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide i.e. W-7, calmodulin-antagonist Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.127 cytosol
-
Rattus norvegicus 5829
-
2.7.1.127 soluble
-
Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Ca2+ only together with calmodulin, completely reversible Rattus norvegicus
2.7.1.127 Ca2+ activation by Ca2+/calmodulin Rattus norvegicus
2.7.1.127 Ca2+ not activated by free Ca2+ Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus inositol 1,4,5-trisphosphate is a second messenger ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus inositol 1,4,5-trisphosphate mobilizes Ca2+ from the intracellular stores of permeabilized cells, enzyme is Ca2+-regulated ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.127 20fold Rattus norvegicus
2.7.1.127 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 RINm5F cell insulin-secreting Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.127 0.00072
-
in absence of calmodulin Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.7.1.127 4°C, 48 h, 10-20% loss of activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate inositol 1,4,5-trisphosphate is a second messenger Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate inositol 1,4,5-trisphosphate mobilizes Ca2+ from the intracellular stores of permeabilized cells, enzyme is Ca2+-regulated Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
Rattus norvegicus
2.7.1.127 Calmodulin activation by Ca2+/calmodulin Rattus norvegicus
2.7.1.127 Calmodulin maximally 5fold stimulation by 0.01 mM Ca2+/calmodulin, reversible Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.127 0.12
-
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
-
Rattus norvegicus