EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide | i.e. W-7, calmodulin-antagonist | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.127 | cytosol | - |
Rattus norvegicus | 5829 | - |
2.7.1.127 | soluble | - |
Rattus norvegicus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | Ca2+ | only together with calmodulin, completely reversible | Rattus norvegicus | |
2.7.1.127 | Ca2+ | activation by Ca2+/calmodulin | Rattus norvegicus | |
2.7.1.127 | Ca2+ | not activated by free Ca2+ | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | inositol 1,4,5-trisphosphate is a second messenger | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | inositol 1,4,5-trisphosphate mobilizes Ca2+ from the intracellular stores of permeabilized cells, enzyme is Ca2+-regulated | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.127 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.127 | 20fold | Rattus norvegicus |
2.7.1.127 | partial | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.127 | RINm5F cell | insulin-secreting | Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.1.127 | 0.00072 | - |
in absence of calmodulin | Rattus norvegicus |
EC Number | Storage Stability | Organism |
---|---|---|
2.7.1.127 | 4°C, 48 h, 10-20% loss of activity | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | inositol 1,4,5-trisphosphate is a second messenger | Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | inositol 1,4,5-trisphosphate mobilizes Ca2+ from the intracellular stores of permeabilized cells, enzyme is Ca2+-regulated | Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | ATP | - |
Rattus norvegicus | |
2.7.1.127 | Calmodulin | activation by Ca2+/calmodulin | Rattus norvegicus | |
2.7.1.127 | Calmodulin | maximally 5fold stimulation by 0.01 mM Ca2+/calmodulin, reversible | Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.127 | 0.12 | - |
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide | - |
Rattus norvegicus |