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Literature summary extracted from

  • Maeda, T.; Imanishi, Y.; Palczewski, K.
    Rhodopsin phosphorylation: 30 years later (2003), Prog. Retin. Eye Res., 22, 417-434.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.14 mastoparan enhances peptide phosphorylation Bos taurus
2.7.11.14 additional information molecular mechanisms of GRK1 activation Bos taurus
2.7.11.14 rhodopsin photolyzed rhodopsin stimulates Bos taurus

Application

EC Number Application Comment Organism
2.7.11.14 medicine mutation in RK is associated with the Oguchi disease Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.14
-
Gallus gallus
2.7.11.14 GRK1 gene encodes a 689 amino acids protein Enteroctopus dofleini
2.7.11.14 GRK1 gene encodes a 689 amino acids protein Doryteuthis pealeii
2.7.11.14 GRK1 gene with 7 exons is located on chromosome 13q34 and encodes a 561 amino acids protein Homo sapiens
2.7.11.14 GRK1 is cloned Oryzias latipes

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.14 additional information
-
Bos taurus
2.7.11.14 additional information RK knockout mice Mus musculus
2.7.11.14 additional information GRK1 mutations causing the Oguchi disease Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.14 recoverin Ca2+-dependent inhibition Bos taurus
2.7.11.14 recoverin Ca2+-dependent inhibition Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.14 membrane membrane-bound Bos taurus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.14 Mg2+
-
Mus musculus
2.7.11.14 Mg2+
-
Homo sapiens
2.7.11.14 Mg2+
-
Rattus norvegicus
2.7.11.14 Mg2+
-
Bos taurus
2.7.11.14 Mg2+
-
Oryzias latipes
2.7.11.14 Mg2+
-
Gallus gallus
2.7.11.14 Mg2+
-
Enteroctopus dofleini
2.7.11.14 Mg2+
-
Doryteuthis pealeii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.14 ATP + rhodopsin Mus musculus
-
ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin Homo sapiens
-
ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin Rattus norvegicus
-
ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin Bos taurus
-
ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin Oryzias latipes
-
ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin Gallus gallus
-
ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin Enteroctopus dofleini
-
ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin Doryteuthis pealeii
-
ADP + phosphorhodopsin
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.14 Bos taurus
-
-
-
2.7.11.14 Doryteuthis pealeii Q9N2R0 squid
-
2.7.11.14 Enteroctopus dofleini O97020
-
-
2.7.11.14 Gallus gallus O73685
-
-
2.7.11.14 Homo sapiens
-
-
-
2.7.11.14 Homo sapiens Q15835
-
-
2.7.11.14 Mus musculus
-
-
-
2.7.11.14 Oryzias latipes
-
-
-
2.7.11.14 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.14 phosphoprotein autophosphorylation sites of RK, major sites are Ser-488 and Thr-489, minor site is Ser-21 Bos taurus
2.7.11.14 phosphoprotein autophosphorylation sites of RK, major sites are Ser-488 and Thr-489, minor site is Ser-21 Homo sapiens
2.7.11.14 side-chain modification
-
Rattus norvegicus
2.7.11.14 side-chain modification GRK1 is geranylgeranylated ex vivo Gallus gallus
2.7.11.14 side-chain modification native enzyme is farnesylated in vitro and in vivo Bos taurus
2.7.11.14 side-chain modification prenylated and carboxyl-methylated at Cys-558 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.14 eye retina Mus musculus
-
2.7.11.14 eye retina Homo sapiens
-
2.7.11.14 eye retina Bos taurus
-
2.7.11.14 eye retina Oryzias latipes
-
2.7.11.14 eye retina Gallus gallus
-
2.7.11.14 eye retina Enteroctopus dofleini
-
2.7.11.14 eye retina Doryteuthis pealeii
-
2.7.11.14 pineal gland
-
Bos taurus
-
2.7.11.14 pineal gland
-
Gallus gallus
-
2.7.11.14 pineal gland GRK1 expression Homo sapiens
-
2.7.11.14 pineal gland GRK1 expression Rattus norvegicus
-
2.7.11.14 retina
-
Bos taurus
-
2.7.11.14 retina
-
Homo sapiens
-
2.7.11.14 retina in rod and cone photoreceptors Mus musculus
-
2.7.11.14 retina in rod and cone photoreceptors Homo sapiens
-
2.7.11.14 retina in rod and cone photoreceptors Gallus gallus
-
2.7.11.14 retina retina-specific expression Enteroctopus dofleini
-
2.7.11.14 retina retina-specific expression Doryteuthis pealeii
-
2.7.11.14 retina expressed exclusively in rods Oryzias latipes
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.14 ATP + peptide
-
Bos taurus ADP + phosphopeptide
-
?
2.7.11.14 ATP + rhodopsin
-
Mus musculus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin
-
Homo sapiens ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin
-
Rattus norvegicus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin
-
Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin
-
Oryzias latipes ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin
-
Gallus gallus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin
-
Enteroctopus dofleini ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin
-
Doryteuthis pealeii ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin regulation of GRK1 Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin highly specific for photobleached rhodopsin Homo sapiens ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin highly specific for photobleached rhodopsin Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin highly specific for photobleached rhodopsin Gallus gallus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin highly specific for photobleached rhodopsin Enteroctopus dofleini ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin highly specific for photobleached rhodopsin Doryteuthis pealeii ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin preferred substrate: photobleached rhodopsin Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin preferred substrate: photobleached rhodopsin Homo sapiens ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin phosphorylation sites of photolyzed rhodopsin Mus musculus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin phosphorylation sites of photolyzed rhodopsin Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin high-gain phosphorylation of rhodopsin Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin domain structure Bos taurus ADP + phosphorhodopsin
-
?