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Literature summary extracted from

  • Nakanishi, S.; Ando, K.; Kawamoto, I.; Matsuda, Y.
    MS-347a, a new inhibitor of myosin light chain kinase from Aspergillus sp. KY52178 (1989), J. Antibiot., 46, 1775-1781.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 MS-347a from Aspergillus sp. KY52178, structurally related to sydowinin B, irreversible, inhibition of calmodulin-dependent and independent activity, IC50: 0.0092 mM Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain Gallus gallus
-
 ADP + myosin light chain phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Gallus gallus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Gallus gallus ADP + myosin light chain phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.18 28
-
 assay at Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 Calmodulin requirement Gallus gallus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.18 0.0092
-
 from Aspergillus sp. KY52178, structurally related to sydowinin B, irreversible, inhibition of calmodulin-dependent and independent activity, IC50: 0.0092 mM Gallus gallus MS-347a