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Literature summary extracted from

  • Jinsart, W.; Ternai, B.; Polya, G.M.
    Inhibition of wheat embryo calcium-dependent protein kinase and avian myosin light chain kinase by flavonoids and related compounds (1991), Biol. Chem. Hoppe-Seyler, 372, 819-827.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 (+)-catechin IC50: 0.44 mM Gallus gallus
2.7.11.18 (-)-epicatechin IC50: 0.32 mM Gallus gallus
2.7.11.18 2,2'-Dihydroxychalcone
-
 Gallus gallus
2.7.11.18 3',4',5'-tri-O-methyltricetin
-
 Gallus gallus
2.7.11.18 3',4'-dihydroxyflavone IC50: 0.262 mM Gallus gallus
2.7.11.18 3,3',4'-trihydroxyflavone IC50: 0.001 mM Gallus gallus
2.7.11.18 5,4'-dihydroxyflavone IC50: 0.024 mM Gallus gallus
2.7.11.18 5,7-dihydroxyflavone IC50: 0.043 mM Gallus gallus
2.7.11.18 7,8,3',4'-tetrahydroxyflavone IC50: 0.02 mM Gallus gallus
2.7.11.18 7-O-methylapigenin
-
 Gallus gallus
2.7.11.18 apigenin IC50: 0.023 mM Gallus gallus
2.7.11.18 chalcone
-
 Gallus gallus
2.7.11.18 dihydroapigenin IC50: 0.17 mM Gallus gallus
2.7.11.18 dihydrofisetin IC50: 0.18 mM Gallus gallus
2.7.11.18 dihydroluteolin
-
 Gallus gallus
2.7.11.18 dihydroquercetin IC50: 0.08 mM Gallus gallus
2.7.11.18 fisetin IC50: 0.005 mM Gallus gallus
2.7.11.18 galangin IC50: 0.02 mM Gallus gallus
2.7.11.18 gossypol
-
 Gallus gallus
2.7.11.18 hesperidin
-
 Gallus gallus
2.7.11.18 isoliquiritigenin
-
 Gallus gallus
2.7.11.18 kaempferid IC50: 0.008 mM Gallus gallus
2.7.11.18 kaempferol IC50: 0.004 mM Gallus gallus
2.7.11.18 luteolin IC50: 0.026 mM Gallus gallus
2.7.11.18 additional information no inhibition by epicatechin, pseudobabtisin, 4-dimethylaminobenzaldehyde Gallus gallus
2.7.11.18 morin IC50: 0.028 mM Gallus gallus
2.7.11.18 myricetin IC50: 0.006 mM Gallus gallus
2.7.11.18 Okanin
-
 Gallus gallus
2.7.11.18 pseudobaptisin
-
 Gallus gallus
2.7.11.18 quercetagetin IC50: 0.026 mM Gallus gallus
2.7.11.18 quercetin IC50: 0.006 mM Gallus gallus
2.7.11.18 quercetrin IC50: 0.137 mM Gallus gallus
2.7.11.18 rutin IC50: 0.32 mM Gallus gallus
2.7.11.18 tricetin IC50: 0.012 mM Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain Gallus gallus
-
 ADP + myosin light chain phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Gallus gallus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 gizzard
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Gallus gallus ADP + myosin light chain phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.18 30
-
 assay at Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 Calmodulin requirement Gallus gallus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.18 0.001
-
 IC50: 0.001 mM Gallus gallus 3,3',4'-trihydroxyflavone
2.7.11.18 0.004
-
 IC50: 0.004 mM Gallus gallus kaempferol
2.7.11.18 0.005
-
 IC50: 0.005 mM Gallus gallus fisetin
2.7.11.18 0.006
-
 IC50: 0.006 mM Gallus gallus quercetin
2.7.11.18 0.006
-
 IC50: 0.006 mM Gallus gallus myricetin
2.7.11.18 0.008
-
 IC50: 0.008 mM Gallus gallus kaempferid
2.7.11.18 0.012
-
 IC50: 0.012 mM Gallus gallus tricetin
2.7.11.18 0.02
-
 IC50: 0.02 mM Gallus gallus galangin
2.7.11.18 0.02
-
 IC50: 0.02 mM Gallus gallus 7,8,3',4'-tetrahydroxyflavone
2.7.11.18 0.023
-
 IC50: 0.023 mM Gallus gallus apigenin
2.7.11.18 0.024
-
 IC50: 0.024 mM Gallus gallus 5,4'-dihydroxyflavone
2.7.11.18 0.026
-
 IC50: 0.026 mM Gallus gallus luteolin
2.7.11.18 0.026
-
 IC50: 0.026 mM Gallus gallus quercetagetin
2.7.11.18 0.028
-
 IC50: 0.028 mM Gallus gallus morin
2.7.11.18 0.043
-
 IC50: 0.043 mM Gallus gallus 5,7-dihydroxyflavone
2.7.11.18 0.08
-
 IC50: 0.08 mM Gallus gallus dihydroquercetin
2.7.11.18 0.137
-
 IC50: 0.137 mM Gallus gallus quercetrin
2.7.11.18 0.17
-
 IC50: 0.17 mM Gallus gallus dihydroapigenin
2.7.11.18 0.18
-
 IC50: 0.18 mM Gallus gallus dihydrofisetin
2.7.11.18 0.262
-
 IC50: 0.262 mM Gallus gallus 3',4'-dihydroxyflavone
2.7.11.18 0.32
-
 IC50: 0.32 mM Gallus gallus rutin
2.7.11.18 0.32
-
 IC50: 0.32 mM Gallus gallus (-)-epicatechin
2.7.11.18 0.44
-
 IC50: 0.44 mM Gallus gallus (+)-catechin