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Literature summary extracted from

  • Jinsart, W.; Ternai, B.; Polya, G.M.
    Inhibition of myosin light chain kinase, cAMP-dependent protein kinase, protein kinase C and of plant Ca(2+)-dependent protein kinase by anthraquinones (1992), Biol. Chem. Hoppe-Seyler, 373, 903-910.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 1,4-diaminoanthraquinone IC50: 0.018 mM Gallus gallus
2.7.11.18 alizarin IC50: 0.014 mM Gallus gallus
2.7.11.18 anthraflavic acid IC50: 0.037 mM Gallus gallus
2.7.11.18 anthrarufin
-
 Gallus gallus
2.7.11.18 chrysazine IC50: 0.02 mM Gallus gallus
2.7.11.18 chrysophanic acid
-
 Gallus gallus
2.7.11.18 emodin IC50: 0.008 mM Gallus gallus
2.7.11.18 mitoxanthrone IC50: 0.002 mM Gallus gallus
2.7.11.18 purpurin IC50: 0.025 mM Gallus gallus
2.7.11.18 quinalizarin IC50: 0.053 mM Gallus gallus
2.7.11.18 quinizarin IC50: 0.026 mM Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain Gallus gallus
-
 ADP + myosin light chain phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Gallus gallus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 gizzard rat pancreatic and turkey gizzard enzyme are immunologically related Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ala
-
 Gallus gallus ADP + ?
-
 ?
2.7.11.18 ATP + myosin light chain
-
 Gallus gallus ADP + myosin light chain phosphate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 Calmodulin requirement Gallus gallus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.18 0.002
-
 IC50: 0.002 mM Gallus gallus mitoxanthrone
2.7.11.18 0.008
-
 IC50: 0.008 mM Gallus gallus emodin
2.7.11.18 0.014
-
 IC50: 0.014 mM Gallus gallus alizarin
2.7.11.18 0.018
-
 IC50: 0.018 mM Gallus gallus 1,4-diaminoanthraquinone
2.7.11.18 0.02
-
 IC50: 0.02 mM Gallus gallus chrysazine
2.7.11.18 0.025
-
 IC50: 0.025 mM Gallus gallus purpurin
2.7.11.18 0.026
-
 IC50: 0.026 mM Gallus gallus quinizarin
2.7.11.18 0.037
-
 IC50: 0.037 mM Gallus gallus anthraflavic acid
2.7.11.18 0.053
-
 IC50: 0.053 mM Gallus gallus quinalizarin