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Literature summary extracted from
- Purification of myosin light chain kinase from bovine cardiac muscle (1980), Proc. Natl. Acad. Sci. USA, 77, 5852-5855.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.11.18 | Calmodulin-binding protein from bovine cardiac muscle | - |
Bos taurus |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.7.11.18 | 0.011 | 0.02 | myosin light chain | 30°C, pH 7 | Bos taurus |  |
| 2.7.11.18 | 0.22 | - |
ATP | 30°C, pH 7 | Bos taurus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.11.18 | Ca2+ | - |
Bos taurus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 2.7.11.18 | 94000 | - |
x * 94000, SDS-PAGE | Bos taurus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.11.18 | ATP + myosin light chain | Bos taurus | - |
ADP + myosin light chain phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.11.18 | Bos taurus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.7.11.18 | cardiac muscle | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 2.7.11.18 | 18.5 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.11.18 | ATP + myosin light chain | - |
Bos taurus | ADP + myosin light chain phosphate | - |
? | |
| 2.7.11.18 | ATP + myosin light chain | acceptor substrates are myosin light chains of cardiac muscle | Bos taurus | ADP + myosin light chain phosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 2.7.11.18 | ? | x * 94000, SDS-PAGE | Bos taurus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 2.7.11.18 | 30 | - |
assay at | Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.11.18 | Calmodulin | requirement | Bos taurus | |
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Release 2023.1 (January 2023)
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