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Literature summary extracted from

  • Paxton, R.; Harris, R.A.
    Regulation of branched-chain alpha-ketoacid dehydrogenase kinase (1984), Arch. Biochem. Biophys., 231, 48-57.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.4 2-Chloroisohexanoate
-
 Oryctolagus cuniculus
2.7.11.4 2-oxo-3-methylpentanoate
-
 Oryctolagus cuniculus
2.7.11.4 2-Oxohexanoate
-
 Oryctolagus cuniculus
2.7.11.4 2-oxoisocaproate kinetics, 40% inhibition at 0.065 mM Oryctolagus cuniculus
2.7.11.4 2-oxoisopentanoate
-
 Oryctolagus cuniculus
2.7.11.4 2-oxopentanoate kinetics Oryctolagus cuniculus
2.7.11.4 acetoacetyl-CoA 40% inhibition at 0.01 mM Oryctolagus cuniculus
2.7.11.4 heparin 40% inhibition at 0.012 mg/ml Oryctolagus cuniculus
2.7.11.4 isobutyryl-CoA
-
 Oryctolagus cuniculus
2.7.11.4 isovaleryl-CoA
-
 Oryctolagus cuniculus
2.7.11.4 malonyl-CoA
-
 Oryctolagus cuniculus
2.7.11.4 methylmalonyl-CoA 40% inhibition at 0.2 mM Oryctolagus cuniculus
2.7.11.4 additional information no inhibition by acetate; no inhibition by acetyl-CoA; no inhibition by lactate; no inhibition by methylcrotonyl-CoA, beta-hydroxy-beta-methylglutaryl-CoA, crotonyl-CoA, octanoyl-CoA, succinyl-CoA, propionyl-CoA, 0.1 mM each, propionate, beta-hydroxybutyrate, acetoacetate, malonate, alpha-ketomalonate, succinate, citrate, oxaloacetate, FAD+, NADPH, 2 mM; no inhibition by NADH, NAD+ 1 mM each Oryctolagus cuniculus
2.7.11.4 n-Octanoate 40% inhibition at 0.5 mM Oryctolagus cuniculus
2.7.11.4 NADP+ 40% inhibition at 1.5 mM Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Oryctolagus cuniculus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.4 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.4 liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]
-
 Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.4 37
-
 assay at Oryctolagus cuniculus