Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lau, K.S.; Fatania, H.R.; Randle, P.J.
    Regulation of the branched chain 2-oxoacid dehydrogenase kinase reaction (1982), FEBS Lett., 144, 57-62.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.4 2-oxoisocaproate
-
Bos taurus
2.7.11.4 3-methyl-2-oxobutanoate
-
Bos taurus
2.7.11.4 4-methyl-2-oxopentanoate
-
Bos taurus
2.7.11.4 ADP
-
Bos taurus
2.7.11.4 branched-chain 2-oxo acids
-
Bos taurus
2.7.11.4 diphosphate
-
Bos taurus
2.7.11.4 MgATP2-
-
Bos taurus
2.7.11.4 additional information no inhibition by acetyl-CoA; no inhibition by coenzyme A Bos taurus
2.7.11.4 thiamine
-
Bos taurus
2.7.11.4 thiamine diphosphate
-
Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.4 0.0126
-
ATP pH 7.5, 30°C Bos taurus
2.7.11.4 0.0126
-
ATP ATP in form of MgATP2- Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.4 mitochondrion
-
Bos taurus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.4 Mg2+ requirement, actual substrate: MgATP2- Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Bos taurus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.4 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.4
-
Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.4 kidney
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]
-
Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
-
?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylates alpha-subunit of multienzyme complex component E1 Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Ser-residues of MW 46000-subunit Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.4 30
-
assay at Bos taurus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.7.11.4 7
-
loss of activity during purification at pH-values below 7 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.11.4 0.00027
-
ADP pH 7.5, 30°C Bos taurus
2.7.11.4 0.00048
-
4-methyl-2-oxopentanoate pH 7.5, 30°C Bos taurus
2.7.11.4 0.00092
-
2-oxoisocaproate pH 7.5, 30°C Bos taurus
2.7.11.4 0.004
-
diphosphate pH 7.5, 30°C Bos taurus
2.7.11.4 0.0059
-
thiamine pH 7.5, 30°C Bos taurus
2.7.11.4 0.0089
-
4-methyl-2-oxopentanoate pH 7.5, 30°C Bos taurus