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Literature summary extracted from

  • Gower, W.R.; Carr, M.C.; Ives, D.H.
    Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol (1979), J. Biol. Chem., 254, 2180-2183.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.113 dCDP slight stimulation, with ATP as substrate Bos taurus
2.7.1.113 dTDP 1 mM, 620% activation of mitochondrial deoxyguanosine kinase, positive modulation with ATP as substrate Bos taurus
2.7.1.113 dTTP 1 mM, 280% activation of mitochondrial deoxyguanosine kinase Bos taurus
2.7.1.113 additional information not activated by dCTP or dATP, with ATP as substrate Bos taurus
2.7.1.113 Sodium diphosphate 1 mM, 120% stimulation of mitochondrial deoxyguanosine kinase Bos taurus
2.7.1.113 UDP 1 mM, 310% activation of mitochondrial deoxyguanosine kinase, with ATP as substrate Bos taurus
2.7.1.113 UTP 1 mM, 190% activation of mitochondrial deoxyguanosine kinase Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.113 dGDP 0.1 mM, 55% inhibition Bos taurus
2.7.1.113 dGMP very weak inhibition Bos taurus
2.7.1.113 dGTP 1 mM, 96% inhibition Bos taurus
2.7.1.113 dITP 0.1 mM, 65% inhibition Bos taurus
2.7.1.113 additional information not inhibited by dADP; not inhibited by dATP; not inhibited by dCTP; not inhibited by GTP Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.113 0.006
-
deoxyguanosine pH 7.5, 37°C, mitochondrial deoxyguanosine kinase Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.113 mitochondrion
-
Bos taurus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.113 Mg2+ required for activity Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.113 ATP + deoxyguanosine Bos taurus enzyme of purine deoxynucleoside salvage pathway ADP + dGMP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.113 Bos taurus
-
calf
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.113 mitochondrial deoxyguanosine kinase, Sephacryl S-200, Blue Sepharose CL6B Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.113 thymus
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.113 ATP + deoxyguanosine no activity with deoxycytidine Bos taurus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyguanosine no activity with inosine and 9-beta-arabinofuranosyladenine Bos taurus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyguanosine no activity with deoxythymidine, uridine and cytosine Bos taurus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyguanosine no activity with adenosine Bos taurus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyguanosine enzyme of purine deoxynucleoside salvage pathway Bos taurus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyinosine
-
Bos taurus ADP + dIMP
-
?
2.7.1.113 ATP + guanosine mitochondrial deoxyguanosine kinase Bos taurus ADP + GMP
-
?

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.1.113 Bos taurus mitochondrial deoxyguanosine kinase, isoelectric focusing
-
5.9