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Literature summary extracted from

  • Van Praag, E.; Zehavi, U.; Goren, R.
    Kinetic properties of ATP-dependent phosphofructokinase from grapefruit juice sacs: effect of TCA cycle intermediates (1999), Biochem. Mol. Biol. Int., 47, 749-756.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.11 2-oxoglutarate competitive inhibition Citrus x paradisi
2.7.1.11 ATP inhibition above 0.08 mM Citrus x paradisi
2.7.1.11 citrate presence of 12 mM Mg2+ relieves inhibition completely Citrus x paradisi
2.7.1.11 isocitrate competitive inhibition Citrus x paradisi
2.7.1.11 malate competitive inhibition Citrus x paradisi
2.7.1.11 succinate competitive inhibition Citrus x paradisi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.11 0.04
-
 ATP pH 7.5 Citrus x paradisi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.11 ATP + D-fructose 6-phosphate Citrus x paradisi
-
 ADP + D-fructose 1,6-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.11 Citrus x paradisi
-
 Macf, cv. Marsh, grapefruit
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.11 pulp
-
 Citrus x paradisi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.11 ATP + D-fructose 6-phosphate
-
 Citrus x paradisi ADP + D-fructose 1,6-bisphosphate
-
 ?
2.7.1.11 ATP + D-fructose 6-phosphate fructose 6-phosphate shows negative cooperativity at low concentrations and positive cooperativity at high concentrations Citrus x paradisi ADP + D-fructose 1,6-bisphosphate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.11 1.3
-
 citrate pH 7.5, theoretical value Citrus x paradisi
2.7.1.11 1.43
-
 malate pH 7.5 Citrus x paradisi
2.7.1.11 3.21
-
 succinate pH 7.5 Citrus x paradisi
2.7.1.11 3.57
-
 isocitrate pH 7.5 Citrus x paradisi
2.7.1.11 3.9
-
 2-oxoglutarate pH 7.5 Citrus x paradisi