BRENDA - Enzyme Database

Phosphofructokinase

Bloxham, D.P.; Lardy, H.A.; The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 8, 239-278 (1973)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.11
ADP
-
Clostridium pasteurianum
2.7.1.11
ADP
-
Fasciola hepatica
2.7.1.11
ADP
-
Rattus norvegicus
2.7.1.11
ADP
-
Saccharomyces cerevisiae
2.7.1.11
AMP
-
Bos taurus
2.7.1.11
AMP
-
Fasciola hepatica
2.7.1.11
AMP
-
Rattus norvegicus
2.7.1.11
AMP
-
Saccharomyces cerevisiae
2.7.1.11
cAMP
-
Fasciola hepatica
2.7.1.11
cAMP
-
Oryctolagus cuniculus
2.7.1.11
cAMP
-
Rattus norvegicus
2.7.1.11
glutathione
activation
Oryctolagus cuniculus
2.7.1.11
NH4+
-
Clostridium pasteurianum
2.7.1.11
NH4+
-
Escherichia coli
2.7.1.11
NH4+
activation of muscle enzyme, inhibitory at high concentrations
Rattus norvegicus
2.7.1.11
NH4+
-
Saccharomyces cerevisiae
2.7.1.11
NH4+
-
Fasciola hepatica
2.7.1.11
NH4+
-
Oryctolagus cuniculus
Crystallization (Commentary)
EC Number
Crystallization
Organism
2.7.1.11
-
Saccharomyces cerevisiae
2.7.1.11
-
Clostridium pasteurianum
2.7.1.11
-
Gallus gallus
2.7.1.11
-
Oryctolagus cuniculus
2.7.1.11
-
Ovis aries
General Stability
EC Number
General Stability
Organism
2.7.1.11
dilution reversibly decreases activity
Oryctolagus cuniculus
2.7.1.11
dilution reversibly decreases activity
Glutamicibacter nicotianae
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.11
2-oxoglutarate
brain PFK, not heart PFK
Rattus norvegicus
2.7.1.11
ADP
plant enzymes
Pisum sativum
2.7.1.11
ADP
plant enzymes
Zea mays
2.7.1.11
ADP
-
Clostridium pasteurianum
2.7.1.11
AMP
-
Brassica oleracea var. gemmifera
2.7.1.11
AMP
weak inhibition
Daucus carota
2.7.1.11
AMP
weak inhibition
Lactobacillus plantarum
2.7.1.11
AMP
weak inhibition
Neurospora crassa
2.7.1.11
AMP
weak inhibition
Pisum sativum
2.7.1.11
AMP
-
Zea mays
2.7.1.11
Antibodies against rabbit muscle enzyme
not rabbit erythrocyte, leukocyte or platelet enzyme
Oryctolagus cuniculus
2.7.1.11
ATP
-
Escherichia coli
2.7.1.11
ATP
ADP partially reverses inhibition
Klebsiella aerogenes
2.7.1.11
ATP
ADP partially reverses inhibition; cAMP partially reverses inhibition; fructose 1,6-bisphosphate partially reverses inhibition; phosphate and AMP partially reverse inhibition
Mus musculus
2.7.1.11
ATP
muscle PFK, strong inhibition at pH 7.1, weak inhibition at pH 7.6-8.5, not inhibited at pH 9.0
Oryctolagus cuniculus
2.7.1.11
ATP
fructose 1,6-bisphosphate partially reverses inhibition; phosphate and AMP partially reverse inhibition
Rattus norvegicus
2.7.1.11
ATP
-
Fasciola hepatica
2.7.1.11
ATP
-
Saccharomyces cerevisiae
2.7.1.11
ATP
-
Bos taurus
2.7.1.11
ATP
-
Ovis aries
2.7.1.11
ATP
-
Homo sapiens
2.7.1.11
cAMP
-
Lactobacillus plantarum
2.7.1.11
cis-aconitate
brain, not heart
Rattus norvegicus
2.7.1.11
citrate
strong inhibition
Arthrobacter crystallopoietes
2.7.1.11
citrate
strong inhibition
Bos taurus
2.7.1.11
citrate
strong inhibition
Brassica oleracea var. gemmifera
2.7.1.11
citrate
strong inhibition
Clostridium pasteurianum
2.7.1.11
citrate
strong inhibition
Daucus carota
2.7.1.11
citrate
strong inhibition
Dictyostelium discoideum
2.7.1.11
citrate
strong inhibition
Escherichia coli
2.7.1.11
citrate
strong inhibition
Fasciola hepatica
2.7.1.11
citrate
strong inhibition
Gallus gallus
2.7.1.11
citrate
strong inhibition
Glutamicibacter nicotianae
2.7.1.11
citrate
strong inhibition
Homo sapiens
2.7.1.11
citrate
strong inhibition
Klebsiella aerogenes
2.7.1.11
citrate
strong inhibition
Lactobacillus casei
2.7.1.11
citrate
strong inhibition
Lactobacillus plantarum
2.7.1.11
citrate
strong inhibition
Mus musculus
2.7.1.11
citrate
strong inhibition
Neurospora crassa
2.7.1.11
citrate
strong inhibition
Oryctolagus cuniculus
2.7.1.11
citrate
strong inhibition
Ovis aries
2.7.1.11
citrate
strong inhibition
Pisum sativum
2.7.1.11
citrate
strong inhibition; synergistic with phosphate and AMP
Rattus norvegicus
2.7.1.11
citrate
strong inhibition
Saccharomyces cerevisiae
2.7.1.11
citrate
strong inhibition
Thermus thermophilus
2.7.1.11
citrate
strong inhibition
Zea mays
2.7.1.11
D-fructose 1,6-bisphosphate
-
Dictyostelium discoideum
2.7.1.11
D-fructose 1,6-bisphosphate
-
Clostridium pasteurianum
2.7.1.11
D-Fructose 1-phosphate
-
Arthrobacter crystallopoietes
2.7.1.11
D-Fructose 1-phosphate
-
Bos taurus
2.7.1.11
D-Fructose 1-phosphate
-
Brassica oleracea var. gemmifera
2.7.1.11
D-Fructose 1-phosphate
-
Clostridium pasteurianum
2.7.1.11
D-Fructose 1-phosphate
-
Daucus carota
2.7.1.11
D-Fructose 1-phosphate
-
Dictyostelium discoideum
2.7.1.11
D-Fructose 1-phosphate
-
Escherichia coli
2.7.1.11
D-Fructose 1-phosphate
-
Fasciola hepatica
2.7.1.11
D-Fructose 1-phosphate
-
Gallus gallus
2.7.1.11
D-Fructose 1-phosphate
-
Glutamicibacter nicotianae
2.7.1.11
D-Fructose 1-phosphate
-
Homo sapiens
2.7.1.11
D-Fructose 1-phosphate
-
Klebsiella aerogenes
2.7.1.11
D-Fructose 1-phosphate
-
Lactobacillus casei
2.7.1.11
D-Fructose 1-phosphate
-
Lactobacillus plantarum
2.7.1.11
D-Fructose 1-phosphate
-
Mus musculus
2.7.1.11
D-Fructose 1-phosphate
-
Neurospora crassa
2.7.1.11
D-Fructose 1-phosphate
-
Oryctolagus cuniculus
2.7.1.11
D-Fructose 1-phosphate
-
Ovis aries
2.7.1.11
D-Fructose 1-phosphate
-
Pisum sativum
2.7.1.11
D-Fructose 1-phosphate
-
Rattus norvegicus
2.7.1.11
D-Fructose 1-phosphate
-
Saccharomyces cerevisiae
2.7.1.11
D-Fructose 1-phosphate
-
Thermus thermophilus
2.7.1.11
D-Fructose 1-phosphate
-
Zea mays
2.7.1.11
isocitrate
brain, not heart
Rattus norvegicus
2.7.1.11
malate
kidney cortex, brain, not heart
Rattus norvegicus
2.7.1.11
Maleic anhydride
muscle and heart enzymes, mechanism
Mus musculus
2.7.1.11
Maleic anhydride
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
2.7.1.11
Maleic anhydride
muscle and heart enzymes, mechanism
Rattus norvegicus
2.7.1.11
Mg2+
brain enzyme, at high concentrations
Mus musculus
2.7.1.11
Mg2+
brain enzyme, at high concentrations
Oryctolagus cuniculus
2.7.1.11
Mg2+
brain enzyme, at high concentrations
Rattus norvegicus
2.7.1.11
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Arthrobacter crystallopoietes
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Bos taurus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Brassica oleracea var. gemmifera
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Clostridium pasteurianum
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Daucus carota
2.7.1.11
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Dictyostelium discoideum
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Escherichia coli
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Fasciola hepatica
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Gallus gallus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Glutamicibacter nicotianae
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Homo sapiens
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Klebsiella aerogenes
2.7.1.11
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Lactobacillus casei
2.7.1.11
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Lactobacillus plantarum
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Mus musculus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Neurospora crassa
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Oryctolagus cuniculus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Ovis aries
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Pisum sativum
2.7.1.11
additional information
heart enzyme, not inhibited by cis-aconitate, L-isocitrate, alpha-ketoglutarate, succinate, fumarate, malate, tricarnallylic acid, CoASH, or acetyl-CoASH; not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Rattus norvegicus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by GTP; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Saccharomyces cerevisiae
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Thermus thermophilus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Zea mays
2.7.1.11
NH4+
muscle PFK, weak, at high concentrations, activation at very low concentrations
Oryctolagus cuniculus
2.7.1.11
phosphoenolpyruvate
-
Mus musculus
2.7.1.11
phosphoenolpyruvate
-
Rattus norvegicus
2.7.1.11
phosphoenolpyruvate
-
Escherichia coli
2.7.1.11
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Mus musculus
2.7.1.11
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
2.7.1.11
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Rattus norvegicus
2.7.1.11
succinate
kidney cortex and brain PFK, heart PFk is not inhibited
Rattus norvegicus
2.7.1.11
Succinic anhydride
muscle and heart enzymes, mechanism
Mus musculus
2.7.1.11
Succinic anhydride
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
2.7.1.11
Succinic anhydride
muscle and heart enzymes, mechanism
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Arthrobacter crystallopoietes
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Bos taurus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Brassica oleracea var. gemmifera
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Clostridium pasteurianum
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Daucus carota
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Dictyostelium discoideum
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Escherichia coli
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Fasciola hepatica
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Gallus gallus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Glutamicibacter nicotianae
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Homo sapiens
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Klebsiella aerogenes
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Lactobacillus casei
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Lactobacillus plantarum
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Mus musculus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Neurospora crassa
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Oryctolagus cuniculus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Ovis aries
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Pisum sativum
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Rattus norvegicus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Saccharomyces cerevisiae
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Thermus thermophilus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Zea mays
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.11
cytosol
-
Arthrobacter crystallopoietes
5829
-
2.7.1.11
cytosol
-
Bos taurus
5829
-
2.7.1.11
cytosol
-
Brassica oleracea var. gemmifera
5829
-
2.7.1.11
cytosol
-
Clostridium pasteurianum
5829
-
2.7.1.11
cytosol
-
Daucus carota
5829
-
2.7.1.11
cytosol
-
Dictyostelium discoideum
5829
-
2.7.1.11
cytosol
-
Escherichia coli
5829
-
2.7.1.11
cytosol
-
Fasciola hepatica
5829
-
2.7.1.11
cytosol
-
Gallus gallus
5829
-
2.7.1.11
cytosol
-
Glutamicibacter nicotianae
5829
-
2.7.1.11
cytosol
-
Homo sapiens
5829
-
2.7.1.11
cytosol
-
Klebsiella aerogenes
5829
-
2.7.1.11
cytosol
-
Lactobacillus casei
5829
-
2.7.1.11
cytosol
-
Lactobacillus plantarum
5829
-
2.7.1.11
cytosol
-
Mus musculus
5829
-
2.7.1.11
cytosol
-
Neurospora crassa
5829
-
2.7.1.11
cytosol
-
Ovis aries
5829
-
2.7.1.11
cytosol
-
Pisum sativum
5829
-
2.7.1.11
cytosol
-
Rattus norvegicus
5829
-
2.7.1.11
cytosol
-
Saccharomyces cerevisiae
5829
-
2.7.1.11
cytosol
-
Thermus thermophilus
5829
-
2.7.1.11
cytosol
-
Zea mays
5829
-
2.7.1.11
cytosol
-
Oryctolagus cuniculus
5829
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.11
Co2+
-
Arthrobacter crystallopoietes
2.7.1.11
Co2+
-
Bos taurus
2.7.1.11
Co2+
-
Brassica oleracea var. gemmifera
2.7.1.11
Co2+
-
Daucus carota
2.7.1.11
Co2+
-
Dictyostelium discoideum
2.7.1.11
Co2+
-
Escherichia coli
2.7.1.11
Co2+
-
Fasciola hepatica
2.7.1.11
Co2+
-
Gallus gallus
2.7.1.11
Co2+
-
Glutamicibacter nicotianae
2.7.1.11
Co2+
-
Homo sapiens
2.7.1.11
Co2+
-
Klebsiella aerogenes
2.7.1.11
Co2+
-
Lactobacillus casei
2.7.1.11
Co2+
-
Lactobacillus plantarum
2.7.1.11
Co2+
-
Mus musculus
2.7.1.11
Co2+
-
Neurospora crassa
2.7.1.11
Co2+
-
Oryctolagus cuniculus
2.7.1.11
Co2+
-
Ovis aries
2.7.1.11
Co2+
-
Pisum sativum
2.7.1.11
Co2+
-
Rattus norvegicus
2.7.1.11
Co2+
-
Saccharomyces cerevisiae
2.7.1.11
Co2+
-
Thermus thermophilus
2.7.1.11
Co2+
-
Zea mays
2.7.1.11
Co2+
-
Clostridium pasteurianum
2.7.1.11
K+
-
Arthrobacter crystallopoietes
2.7.1.11
K+
-
Brassica oleracea var. gemmifera
2.7.1.11
K+
-
Clostridium pasteurianum
2.7.1.11
K+
-
Daucus carota
2.7.1.11
K+
-
Dictyostelium discoideum
2.7.1.11
K+
-
Escherichia coli
2.7.1.11
K+
-
Glutamicibacter nicotianae
2.7.1.11
K+
-
Klebsiella aerogenes
2.7.1.11
K+
-
Lactobacillus casei
2.7.1.11
K+
-
Lactobacillus plantarum
2.7.1.11
K+
-
Mus musculus
2.7.1.11
K+
-
Neurospora crassa
2.7.1.11
K+
-
Pisum sativum
2.7.1.11
K+
-
Rattus norvegicus
2.7.1.11
K+
-
Thermus thermophilus
2.7.1.11
K+
-
Zea mays
2.7.1.11
K+
-
Fasciola hepatica
2.7.1.11
K+
-
Saccharomyces cerevisiae
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Arthrobacter crystallopoietes
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Bos taurus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Brassica oleracea var. gemmifera
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Clostridium pasteurianum
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Daucus carota
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Dictyostelium discoideum
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Escherichia coli
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Fasciola hepatica
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Gallus gallus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Glutamicibacter nicotianae
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Homo sapiens
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Klebsiella aerogenes
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Lactobacillus casei
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Lactobacillus plantarum
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Mus musculus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Neurospora crassa
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Oryctolagus cuniculus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Ovis aries
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Pisum sativum
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Rattus norvegicus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Saccharomyces cerevisiae
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Thermus thermophilus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Zea mays
2.7.1.11
Mn2+
activation
Arthrobacter crystallopoietes
2.7.1.11
Mn2+
activation
Bos taurus
2.7.1.11
Mn2+
activation
Brassica oleracea var. gemmifera
2.7.1.11
Mn2+
activation
Daucus carota
2.7.1.11
Mn2+
activation
Dictyostelium discoideum
2.7.1.11
Mn2+
activation
Escherichia coli
2.7.1.11
Mn2+
activation
Fasciola hepatica
2.7.1.11
Mn2+
activation
Gallus gallus
2.7.1.11
Mn2+
activation
Glutamicibacter nicotianae
2.7.1.11
Mn2+
activation
Homo sapiens
2.7.1.11
Mn2+
activation
Klebsiella aerogenes
2.7.1.11
Mn2+
activation
Lactobacillus casei
2.7.1.11
Mn2+
activation
Lactobacillus plantarum
2.7.1.11
Mn2+
activation
Mus musculus
2.7.1.11
Mn2+
activation
Neurospora crassa
2.7.1.11
Mn2+
activation
Oryctolagus cuniculus
2.7.1.11
Mn2+
activation
Ovis aries
2.7.1.11
Mn2+
activation
Pisum sativum
2.7.1.11
Mn2+
activation
Rattus norvegicus
2.7.1.11
Mn2+
activation
Saccharomyces cerevisiae
2.7.1.11
Mn2+
activation
Thermus thermophilus
2.7.1.11
Mn2+
activation
Zea mays
2.7.1.11
Mn2+
activation
Clostridium pasteurianum
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.7.1.11
35000
-
4 * 35000, isoenzyme PFK1, tetrahedral arranged subunits, SDS-PAGE
Escherichia coli
2.7.1.11
36500
-
x * 36500, sedimentation equilibrium centrifugation in 6 M guanidine
Escherichia coli
2.7.1.11
67000
-
6 * 67000, muscle enzyme, sedimentation equilibrium ultracentrifugation or gel filtration in 6.5 M guanidine
Oryctolagus cuniculus
2.7.1.11
141000
142000
-
Escherichia coli
2.7.1.11
144000
-
-
Clostridium pasteurianum
2.7.1.11
300000
-
gel filtration
Mus musculus
2.7.1.11
380000
-
skeletal muscle
Oryctolagus cuniculus
2.7.1.11
380000
-
-
Rattus norvegicus
2.7.1.11
500000
-
erythrocyte, sucrose density gradient centrifugation
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.11
ATP + D-fructose 6-phosphate
Gallus gallus
-
ADP + D-fructose 1,6-bisphosphate
-
Gallus gallus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Lactobacillus plantarum
-
ADP + D-fructose 1,6-bisphosphate
-
Lactobacillus plantarum
?
2.7.1.11
ATP + D-fructose 6-phosphate
Mus musculus
-
ADP + D-fructose 1,6-bisphosphate
-
Mus musculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Thermus thermophilus
-
ADP + D-fructose 1,6-bisphosphate
-
Thermus thermophilus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Escherichia coli
-
ADP + D-fructose 1,6-bisphosphate
-
Escherichia coli
?
2.7.1.11
ATP + D-fructose 6-phosphate
Homo sapiens
-
ADP + D-fructose 1,6-bisphosphate
-
Homo sapiens
?
2.7.1.11
ATP + D-fructose 6-phosphate
Rattus norvegicus
-
ADP + D-fructose 1,6-bisphosphate
-
Rattus norvegicus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Saccharomyces cerevisiae
-
ADP + D-fructose 1,6-bisphosphate
-
Saccharomyces cerevisiae
?
2.7.1.11
ATP + D-fructose 6-phosphate
Bos taurus
-
ADP + D-fructose 1,6-bisphosphate
-
Bos taurus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Oryctolagus cuniculus
-
ADP + D-fructose 1,6-bisphosphate
-
Oryctolagus cuniculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Neurospora crassa
-
ADP + D-fructose 1,6-bisphosphate
-
Neurospora crassa
?
2.7.1.11
ATP + D-fructose 6-phosphate
Ovis aries
-
ADP + D-fructose 1,6-bisphosphate
-
Ovis aries
?
2.7.1.11
ATP + D-fructose 6-phosphate
Pisum sativum
-
ADP + D-fructose 1,6-bisphosphate
-
Pisum sativum
?
2.7.1.11
ATP + D-fructose 6-phosphate
Zea mays
-
ADP + D-fructose 1,6-bisphosphate
-
Zea mays
?
2.7.1.11
ATP + D-fructose 6-phosphate
Klebsiella aerogenes
-
ADP + D-fructose 1,6-bisphosphate
-
Klebsiella aerogenes
?
2.7.1.11
ATP + D-fructose 6-phosphate
Dictyostelium discoideum
-
ADP + D-fructose 1,6-bisphosphate
-
Dictyostelium discoideum
?
2.7.1.11
ATP + D-fructose 6-phosphate
Lactobacillus casei
-
ADP + D-fructose 1,6-bisphosphate
-
Lactobacillus casei
?
2.7.1.11
ATP + D-fructose 6-phosphate
Clostridium pasteurianum
-
ADP + D-fructose 1,6-bisphosphate
-
Clostridium pasteurianum
?
2.7.1.11
ATP + D-fructose 6-phosphate
Daucus carota
-
ADP + D-fructose 1,6-bisphosphate
-
Daucus carota
?
2.7.1.11
ATP + D-fructose 6-phosphate
Glutamicibacter nicotianae
-
ADP + D-fructose 1,6-bisphosphate
-
Glutamicibacter nicotianae
?
2.7.1.11
ATP + D-fructose 6-phosphate
Fasciola hepatica
-
ADP + D-fructose 1,6-bisphosphate
-
Fasciola hepatica
?
2.7.1.11
ATP + D-fructose 6-phosphate
Arthrobacter crystallopoietes
-
ADP + D-fructose 1,6-bisphosphate
-
Arthrobacter crystallopoietes
?
2.7.1.11
ATP + D-fructose 6-phosphate
Brassica oleracea var. gemmifera
-
ADP + D-fructose 1,6-bisphosphate
-
Brassica oleracea var. gemmifera
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.11
Arthrobacter crystallopoietes
-
-
-
2.7.1.11
Bos taurus
-
calf; ox
-
2.7.1.11
Brassica oleracea var. gemmifera
-
Brussel's sprout
-
2.7.1.11
Clostridium pasteurianum
-
-
-
2.7.1.11
Daucus carota
-
carrot
-
2.7.1.11
Dictyostelium discoideum
-
-
-
2.7.1.11
Escherichia coli
-
-
-
2.7.1.11
Fasciola hepatica
-
liver fluke, from bile duct of infected cattle
-
2.7.1.11
Gallus gallus
-
-
-
2.7.1.11
Glutamicibacter nicotianae
-
-
-
2.7.1.11
Homo sapiens
-
-
-
2.7.1.11
Klebsiella aerogenes
-
-
-
2.7.1.11
Lactobacillus casei
-
-
-
2.7.1.11
Lactobacillus plantarum
-
-
-
2.7.1.11
Mus musculus
-
-
-
2.7.1.11
Neurospora crassa
-
-
-
2.7.1.11
Oryctolagus cuniculus
-
-
-
2.7.1.11
Ovis aries
-
-
-
2.7.1.11
Pisum sativum
-
pea
-
2.7.1.11
Rattus norvegicus
-
-
-
2.7.1.11
Saccharomyces cerevisiae
-
-
-
2.7.1.11
Thermus thermophilus
-
-
-
2.7.1.11
Zea mays
-
maize
-
Purification (Commentary)
EC Number
Commentary
Organism
2.7.1.11
-
Clostridium pasteurianum
2.7.1.11
-
Homo sapiens
2.7.1.11
-
Mus musculus
2.7.1.11
-
Saccharomyces cerevisiae
2.7.1.11
-
Oryctolagus cuniculus
2.7.1.11
-
Bos taurus
2.7.1.11
-
Escherichia coli
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.11
adipose tissue
-
Rattus norvegicus
-
2.7.1.11
brain
-
Homo sapiens
-
2.7.1.11
brain
-
Rattus norvegicus
-
2.7.1.11
brain
-
Ovis aries
-
2.7.1.11
Ehrlich ascites carcinoma cell
-
Mus musculus
-
2.7.1.11
erythrocyte
-
Oryctolagus cuniculus
-
2.7.1.11
erythrocyte
-
Homo sapiens
-
2.7.1.11
heart
-
Bos taurus
-
2.7.1.11
heart
-
Oryctolagus cuniculus
-
2.7.1.11
heart
-
Ovis aries
-
2.7.1.11
kidney
cortex
Oryctolagus cuniculus
-
2.7.1.11
leaf
-
Brassica oleracea var. gemmifera
-
2.7.1.11
lens
calf
Bos taurus
-
2.7.1.11
leukocyte
-
Homo sapiens
-
2.7.1.11
liver
-
Gallus gallus
-
2.7.1.11
liver
-
Homo sapiens
-
2.7.1.11
liver
-
Oryctolagus cuniculus
-
2.7.1.11
muscle
-
Ovis aries
-
2.7.1.11
muscle
-
Rattus norvegicus
-
2.7.1.11
muscle
-
Bos taurus
-
2.7.1.11
muscle
-
Homo sapiens
-
2.7.1.11
muscle
-
Oryctolagus cuniculus
-
2.7.1.11
mycelium
-
Neurospora crassa
-
2.7.1.11
platelet
-
Homo sapiens
-
2.7.1.11
root
-
Daucus carota
-
2.7.1.11
seed
-
Daucus carota
-
2.7.1.11
seed
-
Pisum sativum
-
2.7.1.11
thyroid gland
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.7.1.11
93
-
heart muscle PFK
Bos taurus
2.7.1.11
99.5
-
human skeletal muscle
Homo sapiens
2.7.1.11
114
116
-
Gallus gallus
2.7.1.11
114
116
-
Saccharomyces cerevisiae
2.7.1.11
120
160
skeletal muscle PFK
Oryctolagus cuniculus
2.7.1.11
139
-
erythrocyte enzyme
Oryctolagus cuniculus
2.7.1.11
150
-
-
Mus musculus
2.7.1.11
160
-
-
Clostridium pasteurianum
2.7.1.11
160
-
-
Oryctolagus cuniculus
2.7.1.11
160
-
heart PFK
Ovis aries
2.7.1.11
189
215
-
Escherichia coli
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.11
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Gallus gallus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2.7.1.11
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Mus musculus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2.7.1.11
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Rattus norvegicus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2.7.1.11
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Gallus gallus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2.7.1.11
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Mus musculus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2.7.1.11
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Rattus norvegicus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2.7.1.11
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Gallus gallus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2.7.1.11
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Mus musculus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2.7.1.11
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Rattus norvegicus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2.7.1.11
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Gallus gallus
ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Lactobacillus plantarum
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus plantarum
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Mus musculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Thermus thermophilus
ADP + D-fructose 1,6-bisphosphate
-
640421
Thermus thermophilus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Escherichia coli
ADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Homo sapiens
ADP + D-fructose 1,6-bisphosphate
-
640421
Homo sapiens
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Rattus norvegicus
ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
ADP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Bos taurus
ADP + D-fructose 1,6-bisphosphate
-
640421
Bos taurus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Neurospora crassa
ADP + D-fructose 1,6-bisphosphate
-
640421
Neurospora crassa
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Ovis aries
ADP + D-fructose 1,6-bisphosphate
-
640421
Ovis aries
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Pisum sativum
ADP + D-fructose 1,6-bisphosphate
-
640421
Pisum sativum
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Zea mays
ADP + D-fructose 1,6-bisphosphate
-
640421
Zea mays
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Klebsiella aerogenes
ADP + D-fructose 1,6-bisphosphate
-
640421
Klebsiella aerogenes
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Dictyostelium discoideum
ADP + D-fructose 1,6-bisphosphate
-
640421
Dictyostelium discoideum
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Lactobacillus casei
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus casei
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
ADP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Daucus carota
ADP + D-fructose 1,6-bisphosphate
-
640421
Daucus carota
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Glutamicibacter nicotianae
ADP + D-fructose 1,6-bisphosphate
-
640421
Glutamicibacter nicotianae
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Fasciola hepatica
ADP + D-fructose 1,6-bisphosphate
-
640421
Fasciola hepatica
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Arthrobacter crystallopoietes
ADP + D-fructose 1,6-bisphosphate
-
640421
Arthrobacter crystallopoietes
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Gallus gallus
ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Lactobacillus plantarum
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus plantarum
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Mus musculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Thermus thermophilus
ADP + D-fructose 1,6-bisphosphate
-
640421
Thermus thermophilus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Escherichia coli
ADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Homo sapiens
ADP + D-fructose 1,6-bisphosphate
-
640421
Homo sapiens
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Rattus norvegicus
ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Saccharomyces cerevisiae
ADP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Bos taurus
ADP + D-fructose 1,6-bisphosphate
-
640421
Bos taurus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Oryctolagus cuniculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Neurospora crassa
ADP + D-fructose 1,6-bisphosphate
-
640421
Neurospora crassa
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Ovis aries
ADP + D-fructose 1,6-bisphosphate
-
640421
Ovis aries
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Pisum sativum
ADP + D-fructose 1,6-bisphosphate
-
640421
Pisum sativum
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Zea mays
ADP + D-fructose 1,6-bisphosphate
-
640421
Zea mays
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Klebsiella aerogenes
ADP + D-fructose 1,6-bisphosphate
-
640421
Klebsiella aerogenes
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Dictyostelium discoideum
ADP + D-fructose 1,6-bisphosphate
-
640421
Dictyostelium discoideum
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Lactobacillus casei
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus casei
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Clostridium pasteurianum
ADP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Daucus carota
ADP + D-fructose 1,6-bisphosphate
-
640421
Daucus carota
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Glutamicibacter nicotianae
ADP + D-fructose 1,6-bisphosphate
-
640421
Glutamicibacter nicotianae
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Fasciola hepatica
ADP + D-fructose 1,6-bisphosphate
-
640421
Fasciola hepatica
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Arthrobacter crystallopoietes
ADP + D-fructose 1,6-bisphosphate
-
640421
Arthrobacter crystallopoietes
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
2.7.1.11
ATP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
2.7.1.11
ATP + fructose 1-phosphate
-
640421
Escherichia coli
ADP + fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
ATP + fructose 1-phosphate
5% of activity with D-fructose 6-phosphate
640421
Oryctolagus cuniculus
ADP + fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
CTP + D-fructose 6-phosphate
-
640421
Escherichia coli
CDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
CTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
CDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
CTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
CDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
CTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
CDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
CTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
CDP + D-fructose 1,6-bisphosphate
-
-
-
-
2.7.1.11
dATP + D-fructose 6-phosphate
-
640421
Escherichia coli
dADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
GTP + D-fructose 6-phosphate
-
640421
Escherichia coli
GDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
GTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
GDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
GTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
GDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
GTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
GDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
GTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
GDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
2.7.1.11
ITP + D-fructose 6-phosphate
-
640421
Escherichia coli
IDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
ITP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
IDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
ITP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
IDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
ITP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
IDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
ITP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
IDP + D-fructose 1,6-bisphosphate
-
-
-
-
2.7.1.11
TTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Escherichia coli
TDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
TTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
TDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
2.7.1.11
UTP + D-fructose 6-phosphate
-
640421
Escherichia coli
UDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
UTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
UDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
UTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
UDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
UTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
UDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
UTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
UDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
Subunits
EC Number
Subunits
Commentary
Organism
2.7.1.11
?
x * 36500, sedimentation equilibrium centrifugation in 6 M guanidine
Escherichia coli
2.7.1.11
?
-
Homo sapiens
2.7.1.11
?
-
Mus musculus
2.7.1.11
hexamer
6 * 67000, muscle enzyme, sedimentation equilibrium ultracentrifugation or gel filtration in 6.5 M guanidine
Oryctolagus cuniculus
2.7.1.11
tetramer
-
Clostridium pasteurianum
2.7.1.11
tetramer
4 * 35000, isoenzyme PFK1, tetrahedral arranged subunits, SDS-PAGE
Escherichia coli
2.7.1.11
tetramer
-
Rattus norvegicus
Temperature Stability [°C]
EC Number
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
2.7.1.11
-
-
liver enzyme, 2 h, 80% loss of activity by dissociation of enzyme
Gallus gallus
2.7.1.11
8
-
liver enzyme, 2 h, 60% loss of activity by dissociation of enzyme
Gallus gallus
2.7.1.11
40
60
30 min, stable
Gallus gallus
2.7.1.11
80
-
2 h
Thermus thermophilus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.7.1.11
additional information
-
-
Escherichia coli
2.7.1.11
additional information
-
pH-optimum depends on nucleoside triphosphate substrate
Saccharomyces cerevisiae
2.7.1.11
7.6
-
-
Fasciola hepatica
2.7.1.11
7.6
-
ITP, optima at pH 7.6 and pH 8.2
Saccharomyces cerevisiae
2.7.1.11
7.8
-
with ATP
Saccharomyces cerevisiae
2.7.1.11
8.2
-
ITP, optima at pH 7.6 and pH 8.2
Saccharomyces cerevisiae
pH Stability
EC Number
pH Stability
pH Stability Maximum
Commentary
Organism
2.7.1.11
additional information
-
heart enzyme, mild acidic conditions lead to reversible dissociation and decrease of activity, ATP or fructose 1,6-bisphosphate protects
Ovis aries
2.7.1.11
8
-
-
Oryctolagus cuniculus
2.7.1.11
8
-
relatively stable to inactivation by dilution, muscle enzyme
Ovis aries
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.7.1.11
0.03
-
citrate
brain PFK
Rattus norvegicus
2.7.1.11
0.1
-
cis-aconitate
brain PFK
Rattus norvegicus
2.7.1.11
0.2
-
isocitrate
brain PFK
Rattus norvegicus
2.7.1.11
0.6
-
malate
brain PFK
Rattus norvegicus
2.7.1.11
1.5
-
succinate
brain PFK
Rattus norvegicus
2.7.1.11
2.5
-
alpha-ketoglutarate
brain PFK
Rattus norvegicus
2.7.1.11
2.5
-
ATP
pH 7.1
Oryctolagus cuniculus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.11
ADP
-
Clostridium pasteurianum
2.7.1.11
ADP
-
Fasciola hepatica
2.7.1.11
ADP
-
Rattus norvegicus
2.7.1.11
ADP
-
Saccharomyces cerevisiae
2.7.1.11
AMP
-
Bos taurus
2.7.1.11
AMP
-
Fasciola hepatica
2.7.1.11
AMP
-
Rattus norvegicus
2.7.1.11
AMP
-
Saccharomyces cerevisiae
2.7.1.11
cAMP
-
Fasciola hepatica
2.7.1.11
cAMP
-
Oryctolagus cuniculus
2.7.1.11
cAMP
-
Rattus norvegicus
2.7.1.11
glutathione
activation
Oryctolagus cuniculus
2.7.1.11
NH4+
-
Clostridium pasteurianum
2.7.1.11
NH4+
-
Escherichia coli
2.7.1.11
NH4+
activation of muscle enzyme, inhibitory at high concentrations
Rattus norvegicus
2.7.1.11
NH4+
-
Saccharomyces cerevisiae
2.7.1.11
NH4+
-
Fasciola hepatica
2.7.1.11
NH4+
-
Oryctolagus cuniculus
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
2.7.1.11
-
Saccharomyces cerevisiae
2.7.1.11
-
Clostridium pasteurianum
2.7.1.11
-
Gallus gallus
2.7.1.11
-
Oryctolagus cuniculus
2.7.1.11
-
Ovis aries
General Stability (protein specific)
EC Number
General Stability
Organism
2.7.1.11
dilution reversibly decreases activity
Oryctolagus cuniculus
2.7.1.11
dilution reversibly decreases activity
Glutamicibacter nicotianae
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.11
2-oxoglutarate
brain PFK, not heart PFK
Rattus norvegicus
2.7.1.11
ADP
plant enzymes
Pisum sativum
2.7.1.11
ADP
plant enzymes
Zea mays
2.7.1.11
ADP
-
Clostridium pasteurianum
2.7.1.11
AMP
-
Brassica oleracea var. gemmifera
2.7.1.11
AMP
weak inhibition
Daucus carota
2.7.1.11
AMP
weak inhibition
Lactobacillus plantarum
2.7.1.11
AMP
weak inhibition
Neurospora crassa
2.7.1.11
AMP
weak inhibition
Pisum sativum
2.7.1.11
AMP
-
Zea mays
2.7.1.11
Antibodies against rabbit muscle enzyme
not rabbit erythrocyte, leukocyte or platelet enzyme
Oryctolagus cuniculus
2.7.1.11
ATP
-
Escherichia coli
2.7.1.11
ATP
ADP partially reverses inhibition
Klebsiella aerogenes
2.7.1.11
ATP
ADP partially reverses inhibition; cAMP partially reverses inhibition; fructose 1,6-bisphosphate partially reverses inhibition; phosphate and AMP partially reverse inhibition
Mus musculus
2.7.1.11
ATP
muscle PFK, strong inhibition at pH 7.1, weak inhibition at pH 7.6-8.5, not inhibited at pH 9.0
Oryctolagus cuniculus
2.7.1.11
ATP
fructose 1,6-bisphosphate partially reverses inhibition; phosphate and AMP partially reverse inhibition
Rattus norvegicus
2.7.1.11
ATP
-
Fasciola hepatica
2.7.1.11
ATP
-
Saccharomyces cerevisiae
2.7.1.11
ATP
-
Bos taurus
2.7.1.11
ATP
-
Ovis aries
2.7.1.11
ATP
-
Homo sapiens
2.7.1.11
cAMP
-
Lactobacillus plantarum
2.7.1.11
cis-aconitate
brain, not heart
Rattus norvegicus
2.7.1.11
citrate
strong inhibition
Arthrobacter crystallopoietes
2.7.1.11
citrate
strong inhibition
Bos taurus
2.7.1.11
citrate
strong inhibition
Brassica oleracea var. gemmifera
2.7.1.11
citrate
strong inhibition
Clostridium pasteurianum
2.7.1.11
citrate
strong inhibition
Daucus carota
2.7.1.11
citrate
strong inhibition
Dictyostelium discoideum
2.7.1.11
citrate
strong inhibition
Escherichia coli
2.7.1.11
citrate
strong inhibition
Fasciola hepatica
2.7.1.11
citrate
strong inhibition
Gallus gallus
2.7.1.11
citrate
strong inhibition
Glutamicibacter nicotianae
2.7.1.11
citrate
strong inhibition
Homo sapiens
2.7.1.11
citrate
strong inhibition
Klebsiella aerogenes
2.7.1.11
citrate
strong inhibition
Lactobacillus casei
2.7.1.11
citrate
strong inhibition
Lactobacillus plantarum
2.7.1.11
citrate
strong inhibition
Mus musculus
2.7.1.11
citrate
strong inhibition
Neurospora crassa
2.7.1.11
citrate
strong inhibition
Oryctolagus cuniculus
2.7.1.11
citrate
strong inhibition
Ovis aries
2.7.1.11
citrate
strong inhibition
Pisum sativum
2.7.1.11
citrate
strong inhibition; synergistic with phosphate and AMP
Rattus norvegicus
2.7.1.11
citrate
strong inhibition
Saccharomyces cerevisiae
2.7.1.11
citrate
strong inhibition
Thermus thermophilus
2.7.1.11
citrate
strong inhibition
Zea mays
2.7.1.11
D-fructose 1,6-bisphosphate
-
Dictyostelium discoideum
2.7.1.11
D-fructose 1,6-bisphosphate
-
Clostridium pasteurianum
2.7.1.11
D-Fructose 1-phosphate
-
Arthrobacter crystallopoietes
2.7.1.11
D-Fructose 1-phosphate
-
Bos taurus
2.7.1.11
D-Fructose 1-phosphate
-
Brassica oleracea var. gemmifera
2.7.1.11
D-Fructose 1-phosphate
-
Clostridium pasteurianum
2.7.1.11
D-Fructose 1-phosphate
-
Daucus carota
2.7.1.11
D-Fructose 1-phosphate
-
Dictyostelium discoideum
2.7.1.11
D-Fructose 1-phosphate
-
Escherichia coli
2.7.1.11
D-Fructose 1-phosphate
-
Fasciola hepatica
2.7.1.11
D-Fructose 1-phosphate
-
Gallus gallus
2.7.1.11
D-Fructose 1-phosphate
-
Glutamicibacter nicotianae
2.7.1.11
D-Fructose 1-phosphate
-
Homo sapiens
2.7.1.11
D-Fructose 1-phosphate
-
Klebsiella aerogenes
2.7.1.11
D-Fructose 1-phosphate
-
Lactobacillus casei
2.7.1.11
D-Fructose 1-phosphate
-
Lactobacillus plantarum
2.7.1.11
D-Fructose 1-phosphate
-
Mus musculus
2.7.1.11
D-Fructose 1-phosphate
-
Neurospora crassa
2.7.1.11
D-Fructose 1-phosphate
-
Oryctolagus cuniculus
2.7.1.11
D-Fructose 1-phosphate
-
Ovis aries
2.7.1.11
D-Fructose 1-phosphate
-
Pisum sativum
2.7.1.11
D-Fructose 1-phosphate
-
Rattus norvegicus
2.7.1.11
D-Fructose 1-phosphate
-
Saccharomyces cerevisiae
2.7.1.11
D-Fructose 1-phosphate
-
Thermus thermophilus
2.7.1.11
D-Fructose 1-phosphate
-
Zea mays
2.7.1.11
isocitrate
brain, not heart
Rattus norvegicus
2.7.1.11
malate
kidney cortex, brain, not heart
Rattus norvegicus
2.7.1.11
Maleic anhydride
muscle and heart enzymes, mechanism
Mus musculus
2.7.1.11
Maleic anhydride
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
2.7.1.11
Maleic anhydride
muscle and heart enzymes, mechanism
Rattus norvegicus
2.7.1.11
Mg2+
brain enzyme, at high concentrations
Mus musculus
2.7.1.11
Mg2+
brain enzyme, at high concentrations
Oryctolagus cuniculus
2.7.1.11
Mg2+
brain enzyme, at high concentrations
Rattus norvegicus
2.7.1.11
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Arthrobacter crystallopoietes
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Bos taurus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Brassica oleracea var. gemmifera
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Clostridium pasteurianum
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Daucus carota
2.7.1.11
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Dictyostelium discoideum
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Escherichia coli
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Fasciola hepatica
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Gallus gallus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Glutamicibacter nicotianae
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Homo sapiens
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Klebsiella aerogenes
2.7.1.11
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Lactobacillus casei
2.7.1.11
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Lactobacillus plantarum
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Mus musculus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Neurospora crassa
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Oryctolagus cuniculus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Ovis aries
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Pisum sativum
2.7.1.11
additional information
heart enzyme, not inhibited by cis-aconitate, L-isocitrate, alpha-ketoglutarate, succinate, fumarate, malate, tricarnallylic acid, CoASH, or acetyl-CoASH; not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Rattus norvegicus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by GTP; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Saccharomyces cerevisiae
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Thermus thermophilus
2.7.1.11
additional information
not inhibited by fructose 1,6-bisphosphate
Zea mays
2.7.1.11
NH4+
muscle PFK, weak, at high concentrations, activation at very low concentrations
Oryctolagus cuniculus
2.7.1.11
phosphoenolpyruvate
-
Mus musculus
2.7.1.11
phosphoenolpyruvate
-
Escherichia coli
2.7.1.11
phosphoenolpyruvate
-
Rattus norvegicus
2.7.1.11
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Mus musculus
2.7.1.11
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
2.7.1.11
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Rattus norvegicus
2.7.1.11
succinate
kidney cortex and brain PFK, heart PFk is not inhibited
Rattus norvegicus
2.7.1.11
Succinic anhydride
muscle and heart enzymes, mechanism
Mus musculus
2.7.1.11
Succinic anhydride
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
2.7.1.11
Succinic anhydride
muscle and heart enzymes, mechanism
Rattus norvegicus
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.7.1.11
0.03
-
citrate
brain PFK
Rattus norvegicus
2.7.1.11
0.1
-
cis-aconitate
brain PFK
Rattus norvegicus
2.7.1.11
0.2
-
isocitrate
brain PFK
Rattus norvegicus
2.7.1.11
0.6
-
malate
brain PFK
Rattus norvegicus
2.7.1.11
1.5
-
succinate
brain PFK
Rattus norvegicus
2.7.1.11
2.5
-
alpha-ketoglutarate
brain PFK
Rattus norvegicus
2.7.1.11
2.5
-
ATP
pH 7.1
Oryctolagus cuniculus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Arthrobacter crystallopoietes
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Bos taurus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Brassica oleracea var. gemmifera
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Clostridium pasteurianum
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Daucus carota
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Dictyostelium discoideum
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Escherichia coli
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Fasciola hepatica
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Gallus gallus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Glutamicibacter nicotianae
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Homo sapiens
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Klebsiella aerogenes
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Lactobacillus casei
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Lactobacillus plantarum
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Mus musculus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Neurospora crassa
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Oryctolagus cuniculus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Ovis aries
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Pisum sativum
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Rattus norvegicus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Saccharomyces cerevisiae
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Thermus thermophilus
2.7.1.11
additional information
-
additional information
kinetic data of various organism
Zea mays
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.11
cytosol
-
Arthrobacter crystallopoietes
5829
-
2.7.1.11
cytosol
-
Bos taurus
5829
-
2.7.1.11
cytosol
-
Brassica oleracea var. gemmifera
5829
-
2.7.1.11
cytosol
-
Clostridium pasteurianum
5829
-
2.7.1.11
cytosol
-
Daucus carota
5829
-
2.7.1.11
cytosol
-
Dictyostelium discoideum
5829
-
2.7.1.11
cytosol
-
Escherichia coli
5829
-
2.7.1.11
cytosol
-
Fasciola hepatica
5829
-
2.7.1.11
cytosol
-
Gallus gallus
5829
-
2.7.1.11
cytosol
-
Glutamicibacter nicotianae
5829
-
2.7.1.11
cytosol
-
Homo sapiens
5829
-
2.7.1.11
cytosol
-
Klebsiella aerogenes
5829
-
2.7.1.11
cytosol
-
Lactobacillus casei
5829
-
2.7.1.11
cytosol
-
Lactobacillus plantarum
5829
-
2.7.1.11
cytosol
-
Mus musculus
5829
-
2.7.1.11
cytosol
-
Neurospora crassa
5829
-
2.7.1.11
cytosol
-
Ovis aries
5829
-
2.7.1.11
cytosol
-
Pisum sativum
5829
-
2.7.1.11
cytosol
-
Rattus norvegicus
5829
-
2.7.1.11
cytosol
-
Saccharomyces cerevisiae
5829
-
2.7.1.11
cytosol
-
Thermus thermophilus
5829
-
2.7.1.11
cytosol
-
Zea mays
5829
-
2.7.1.11
cytosol
-
Oryctolagus cuniculus
5829
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.11
Co2+
-
Arthrobacter crystallopoietes
2.7.1.11
Co2+
-
Bos taurus
2.7.1.11
Co2+
-
Brassica oleracea var. gemmifera
2.7.1.11
Co2+
-
Daucus carota
2.7.1.11
Co2+
-
Dictyostelium discoideum
2.7.1.11
Co2+
-
Escherichia coli
2.7.1.11
Co2+
-
Fasciola hepatica
2.7.1.11
Co2+
-
Gallus gallus
2.7.1.11
Co2+
-
Glutamicibacter nicotianae
2.7.1.11
Co2+
-
Homo sapiens
2.7.1.11
Co2+
-
Klebsiella aerogenes
2.7.1.11
Co2+
-
Lactobacillus casei
2.7.1.11
Co2+
-
Lactobacillus plantarum
2.7.1.11
Co2+
-
Mus musculus
2.7.1.11
Co2+
-
Neurospora crassa
2.7.1.11
Co2+
-
Oryctolagus cuniculus
2.7.1.11
Co2+
-
Ovis aries
2.7.1.11
Co2+
-
Pisum sativum
2.7.1.11
Co2+
-
Rattus norvegicus
2.7.1.11
Co2+
-
Saccharomyces cerevisiae
2.7.1.11
Co2+
-
Thermus thermophilus
2.7.1.11
Co2+
-
Zea mays
2.7.1.11
Co2+
-
Clostridium pasteurianum
2.7.1.11
K+
-
Arthrobacter crystallopoietes
2.7.1.11
K+
-
Brassica oleracea var. gemmifera
2.7.1.11
K+
-
Clostridium pasteurianum
2.7.1.11
K+
-
Daucus carota
2.7.1.11
K+
-
Dictyostelium discoideum
2.7.1.11
K+
-
Escherichia coli
2.7.1.11
K+
-
Glutamicibacter nicotianae
2.7.1.11
K+
-
Klebsiella aerogenes
2.7.1.11
K+
-
Lactobacillus casei
2.7.1.11
K+
-
Lactobacillus plantarum
2.7.1.11
K+
-
Mus musculus
2.7.1.11
K+
-
Neurospora crassa
2.7.1.11
K+
-
Pisum sativum
2.7.1.11
K+
-
Rattus norvegicus
2.7.1.11
K+
-
Thermus thermophilus
2.7.1.11
K+
-
Zea mays
2.7.1.11
K+
-
Fasciola hepatica
2.7.1.11
K+
-
Saccharomyces cerevisiae
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Arthrobacter crystallopoietes
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Bos taurus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Brassica oleracea var. gemmifera
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Clostridium pasteurianum
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Daucus carota
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Dictyostelium discoideum
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Escherichia coli
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Fasciola hepatica
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Gallus gallus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Glutamicibacter nicotianae
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Homo sapiens
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Klebsiella aerogenes
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Lactobacillus casei
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Lactobacillus plantarum
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Mus musculus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Neurospora crassa
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Oryctolagus cuniculus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Ovis aries
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Pisum sativum
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Rattus norvegicus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Saccharomyces cerevisiae
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Thermus thermophilus
2.7.1.11
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Zea mays
2.7.1.11
Mn2+
activation
Arthrobacter crystallopoietes
2.7.1.11
Mn2+
activation
Bos taurus
2.7.1.11
Mn2+
activation
Brassica oleracea var. gemmifera
2.7.1.11
Mn2+
activation
Daucus carota
2.7.1.11
Mn2+
activation
Dictyostelium discoideum
2.7.1.11
Mn2+
activation
Escherichia coli
2.7.1.11
Mn2+
activation
Fasciola hepatica
2.7.1.11
Mn2+
activation
Gallus gallus
2.7.1.11
Mn2+
activation
Glutamicibacter nicotianae
2.7.1.11
Mn2+
activation
Homo sapiens
2.7.1.11
Mn2+
activation
Klebsiella aerogenes
2.7.1.11
Mn2+
activation
Lactobacillus casei
2.7.1.11
Mn2+
activation
Lactobacillus plantarum
2.7.1.11
Mn2+
activation
Mus musculus
2.7.1.11
Mn2+
activation
Neurospora crassa
2.7.1.11
Mn2+
activation
Oryctolagus cuniculus
2.7.1.11
Mn2+
activation
Ovis aries
2.7.1.11
Mn2+
activation
Pisum sativum
2.7.1.11
Mn2+
activation
Rattus norvegicus
2.7.1.11
Mn2+
activation
Saccharomyces cerevisiae
2.7.1.11
Mn2+
activation
Thermus thermophilus
2.7.1.11
Mn2+
activation
Zea mays
2.7.1.11
Mn2+
activation
Clostridium pasteurianum
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.7.1.11
35000
-
4 * 35000, isoenzyme PFK1, tetrahedral arranged subunits, SDS-PAGE
Escherichia coli
2.7.1.11
36500
-
x * 36500, sedimentation equilibrium centrifugation in 6 M guanidine
Escherichia coli
2.7.1.11
67000
-
6 * 67000, muscle enzyme, sedimentation equilibrium ultracentrifugation or gel filtration in 6.5 M guanidine
Oryctolagus cuniculus
2.7.1.11
141000
142000
-
Escherichia coli
2.7.1.11
144000
-
-
Clostridium pasteurianum
2.7.1.11
300000
-
gel filtration
Mus musculus
2.7.1.11
380000
-
skeletal muscle
Oryctolagus cuniculus
2.7.1.11
380000
-
-
Rattus norvegicus
2.7.1.11
500000
-
erythrocyte, sucrose density gradient centrifugation
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.11
ATP + D-fructose 6-phosphate
Gallus gallus
-
ADP + D-fructose 1,6-bisphosphate
-
Gallus gallus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Lactobacillus plantarum
-
ADP + D-fructose 1,6-bisphosphate
-
Lactobacillus plantarum
?
2.7.1.11
ATP + D-fructose 6-phosphate
Mus musculus
-
ADP + D-fructose 1,6-bisphosphate
-
Mus musculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Thermus thermophilus
-
ADP + D-fructose 1,6-bisphosphate
-
Thermus thermophilus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Escherichia coli
-
ADP + D-fructose 1,6-bisphosphate
-
Escherichia coli
?
2.7.1.11
ATP + D-fructose 6-phosphate
Homo sapiens
-
ADP + D-fructose 1,6-bisphosphate
-
Homo sapiens
?
2.7.1.11
ATP + D-fructose 6-phosphate
Rattus norvegicus
-
ADP + D-fructose 1,6-bisphosphate
-
Rattus norvegicus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Saccharomyces cerevisiae
-
ADP + D-fructose 1,6-bisphosphate
-
Saccharomyces cerevisiae
?
2.7.1.11
ATP + D-fructose 6-phosphate
Bos taurus
-
ADP + D-fructose 1,6-bisphosphate
-
Bos taurus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Oryctolagus cuniculus
-
ADP + D-fructose 1,6-bisphosphate
-
Oryctolagus cuniculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
Neurospora crassa
-
ADP + D-fructose 1,6-bisphosphate
-
Neurospora crassa
?
2.7.1.11
ATP + D-fructose 6-phosphate
Ovis aries
-
ADP + D-fructose 1,6-bisphosphate
-
Ovis aries
?
2.7.1.11
ATP + D-fructose 6-phosphate
Pisum sativum
-
ADP + D-fructose 1,6-bisphosphate
-
Pisum sativum
?
2.7.1.11
ATP + D-fructose 6-phosphate
Zea mays
-
ADP + D-fructose 1,6-bisphosphate
-
Zea mays
?
2.7.1.11
ATP + D-fructose 6-phosphate
Klebsiella aerogenes
-
ADP + D-fructose 1,6-bisphosphate
-
Klebsiella aerogenes
?
2.7.1.11
ATP + D-fructose 6-phosphate
Dictyostelium discoideum
-
ADP + D-fructose 1,6-bisphosphate
-
Dictyostelium discoideum
?
2.7.1.11
ATP + D-fructose 6-phosphate
Lactobacillus casei
-
ADP + D-fructose 1,6-bisphosphate
-
Lactobacillus casei
?
2.7.1.11
ATP + D-fructose 6-phosphate
Clostridium pasteurianum
-
ADP + D-fructose 1,6-bisphosphate
-
Clostridium pasteurianum
?
2.7.1.11
ATP + D-fructose 6-phosphate
Daucus carota
-
ADP + D-fructose 1,6-bisphosphate
-
Daucus carota
?
2.7.1.11
ATP + D-fructose 6-phosphate
Glutamicibacter nicotianae
-
ADP + D-fructose 1,6-bisphosphate
-
Glutamicibacter nicotianae
?
2.7.1.11
ATP + D-fructose 6-phosphate
Fasciola hepatica
-
ADP + D-fructose 1,6-bisphosphate
-
Fasciola hepatica
?
2.7.1.11
ATP + D-fructose 6-phosphate
Arthrobacter crystallopoietes
-
ADP + D-fructose 1,6-bisphosphate
-
Arthrobacter crystallopoietes
?
2.7.1.11
ATP + D-fructose 6-phosphate
Brassica oleracea var. gemmifera
-
ADP + D-fructose 1,6-bisphosphate
-
Brassica oleracea var. gemmifera
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.1.11
-
Clostridium pasteurianum
2.7.1.11
-
Homo sapiens
2.7.1.11
-
Mus musculus
2.7.1.11
-
Saccharomyces cerevisiae
2.7.1.11
-
Oryctolagus cuniculus
2.7.1.11
-
Bos taurus
2.7.1.11
-
Escherichia coli
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.11
adipose tissue
-
Rattus norvegicus
-
2.7.1.11
brain
-
Homo sapiens
-
2.7.1.11
brain
-
Rattus norvegicus
-
2.7.1.11
brain
-
Ovis aries
-
2.7.1.11
Ehrlich ascites carcinoma cell
-
Mus musculus
-
2.7.1.11
erythrocyte
-
Oryctolagus cuniculus
-
2.7.1.11
erythrocyte
-
Homo sapiens
-
2.7.1.11
heart
-
Bos taurus
-
2.7.1.11
heart
-
Oryctolagus cuniculus
-
2.7.1.11
heart
-
Ovis aries
-
2.7.1.11
kidney
cortex
Oryctolagus cuniculus
-
2.7.1.11
leaf
-
Brassica oleracea var. gemmifera
-
2.7.1.11
lens
calf
Bos taurus
-
2.7.1.11
leukocyte
-
Homo sapiens
-
2.7.1.11
liver
-
Gallus gallus
-
2.7.1.11
liver
-
Homo sapiens
-
2.7.1.11
liver
-
Oryctolagus cuniculus
-
2.7.1.11
muscle
-
Ovis aries
-
2.7.1.11
muscle
-
Rattus norvegicus
-
2.7.1.11
muscle
-
Bos taurus
-
2.7.1.11
muscle
-
Homo sapiens
-
2.7.1.11
muscle
-
Oryctolagus cuniculus
-
2.7.1.11
mycelium
-
Neurospora crassa
-
2.7.1.11
platelet
-
Homo sapiens
-
2.7.1.11
root
-
Daucus carota
-
2.7.1.11
seed
-
Daucus carota
-
2.7.1.11
seed
-
Pisum sativum
-
2.7.1.11
thyroid gland
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.7.1.11
93
-
heart muscle PFK
Bos taurus
2.7.1.11
99.5
-
human skeletal muscle
Homo sapiens
2.7.1.11
114
116
-
Gallus gallus
2.7.1.11
114
116
-
Saccharomyces cerevisiae
2.7.1.11
120
160
skeletal muscle PFK
Oryctolagus cuniculus
2.7.1.11
139
-
erythrocyte enzyme
Oryctolagus cuniculus
2.7.1.11
150
-
-
Mus musculus
2.7.1.11
160
-
-
Clostridium pasteurianum
2.7.1.11
160
-
-
Oryctolagus cuniculus
2.7.1.11
160
-
heart PFK
Ovis aries
2.7.1.11
189
215
-
Escherichia coli
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.11
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Gallus gallus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2.7.1.11
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Mus musculus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2.7.1.11
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Rattus norvegicus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2.7.1.11
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Gallus gallus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2.7.1.11
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Mus musculus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2.7.1.11
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Rattus norvegicus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2.7.1.11
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Gallus gallus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2.7.1.11
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Mus musculus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2.7.1.11
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Rattus norvegicus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2.7.1.11
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Gallus gallus
ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Lactobacillus plantarum
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus plantarum
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Mus musculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Thermus thermophilus
ADP + D-fructose 1,6-bisphosphate
-
640421
Thermus thermophilus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Escherichia coli
ADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Homo sapiens
ADP + D-fructose 1,6-bisphosphate
-
640421
Homo sapiens
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Rattus norvegicus
ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
ADP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Bos taurus
ADP + D-fructose 1,6-bisphosphate
-
640421
Bos taurus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Neurospora crassa
ADP + D-fructose 1,6-bisphosphate
-
640421
Neurospora crassa
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Ovis aries
ADP + D-fructose 1,6-bisphosphate
-
640421
Ovis aries
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Pisum sativum
ADP + D-fructose 1,6-bisphosphate
-
640421
Pisum sativum
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Zea mays
ADP + D-fructose 1,6-bisphosphate
-
640421
Zea mays
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Klebsiella aerogenes
ADP + D-fructose 1,6-bisphosphate
-
640421
Klebsiella aerogenes
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Dictyostelium discoideum
ADP + D-fructose 1,6-bisphosphate
-
640421
Dictyostelium discoideum
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Lactobacillus casei
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus casei
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
ADP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Daucus carota
ADP + D-fructose 1,6-bisphosphate
-
640421
Daucus carota
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Glutamicibacter nicotianae
ADP + D-fructose 1,6-bisphosphate
-
640421
Glutamicibacter nicotianae
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Fasciola hepatica
ADP + D-fructose 1,6-bisphosphate
-
640421
Fasciola hepatica
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Arthrobacter crystallopoietes
ADP + D-fructose 1,6-bisphosphate
-
640421
Arthrobacter crystallopoietes
?
2.7.1.11
ATP + D-fructose 6-phosphate
-
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Gallus gallus
ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Lactobacillus plantarum
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus plantarum
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Mus musculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Thermus thermophilus
ADP + D-fructose 1,6-bisphosphate
-
640421
Thermus thermophilus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Escherichia coli
ADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Homo sapiens
ADP + D-fructose 1,6-bisphosphate
-
640421
Homo sapiens
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Rattus norvegicus
ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Saccharomyces cerevisiae
ADP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Bos taurus
ADP + D-fructose 1,6-bisphosphate
-
640421
Bos taurus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Oryctolagus cuniculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Neurospora crassa
ADP + D-fructose 1,6-bisphosphate
-
640421
Neurospora crassa
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Ovis aries
ADP + D-fructose 1,6-bisphosphate
-
640421
Ovis aries
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Pisum sativum
ADP + D-fructose 1,6-bisphosphate
-
640421
Pisum sativum
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Zea mays
ADP + D-fructose 1,6-bisphosphate
-
640421
Zea mays
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Klebsiella aerogenes
ADP + D-fructose 1,6-bisphosphate
-
640421
Klebsiella aerogenes
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Dictyostelium discoideum
ADP + D-fructose 1,6-bisphosphate
-
640421
Dictyostelium discoideum
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Lactobacillus casei
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus casei
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Clostridium pasteurianum
ADP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Daucus carota
ADP + D-fructose 1,6-bisphosphate
-
640421
Daucus carota
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Glutamicibacter nicotianae
ADP + D-fructose 1,6-bisphosphate
-
640421
Glutamicibacter nicotianae
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Fasciola hepatica
ADP + D-fructose 1,6-bisphosphate
-
640421
Fasciola hepatica
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Arthrobacter crystallopoietes
ADP + D-fructose 1,6-bisphosphate
-
640421
Arthrobacter crystallopoietes
?
2.7.1.11
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
2.7.1.11
ATP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
2.7.1.11
ATP + fructose 1-phosphate
-
640421
Escherichia coli
ADP + fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
ATP + fructose 1-phosphate
5% of activity with D-fructose 6-phosphate
640421
Oryctolagus cuniculus
ADP + fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
CTP + D-fructose 6-phosphate
-
640421
Escherichia coli
CDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
CTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
CDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
CTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
CDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
CTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
CDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
CTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
CDP + D-fructose 1,6-bisphosphate
-
-
-
-
2.7.1.11
dATP + D-fructose 6-phosphate
-
640421
Escherichia coli
dADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
GTP + D-fructose 6-phosphate
-
640421
Escherichia coli
GDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
GTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
GDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
GTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
GDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
GTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
GDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
GTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
GDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
2.7.1.11
ITP + D-fructose 6-phosphate
-
640421
Escherichia coli
IDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
ITP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
IDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
ITP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
IDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
ITP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
IDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
ITP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
IDP + D-fructose 1,6-bisphosphate
-
-
-
-
2.7.1.11
TTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Escherichia coli
TDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
TTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
TDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
2.7.1.11
UTP + D-fructose 6-phosphate
-
640421
Escherichia coli
UDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
2.7.1.11
UTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
UDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
2.7.1.11
UTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
UDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2.7.1.11
UTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
UDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
2.7.1.11
UTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
UDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.7.1.11
?
x * 36500, sedimentation equilibrium centrifugation in 6 M guanidine
Escherichia coli
2.7.1.11
?
-
Homo sapiens
2.7.1.11
?
-
Mus musculus
2.7.1.11
hexamer
6 * 67000, muscle enzyme, sedimentation equilibrium ultracentrifugation or gel filtration in 6.5 M guanidine
Oryctolagus cuniculus
2.7.1.11
tetramer
-
Clostridium pasteurianum
2.7.1.11
tetramer
4 * 35000, isoenzyme PFK1, tetrahedral arranged subunits, SDS-PAGE
Escherichia coli
2.7.1.11
tetramer
-
Rattus norvegicus
Temperature Stability [°C] (protein specific)
EC Number
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
2.7.1.11
-
-
liver enzyme, 2 h, 80% loss of activity by dissociation of enzyme
Gallus gallus
2.7.1.11
8
-
liver enzyme, 2 h, 60% loss of activity by dissociation of enzyme
Gallus gallus
2.7.1.11
40
60
30 min, stable
Gallus gallus
2.7.1.11
80
-
2 h
Thermus thermophilus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.7.1.11
additional information
-
-
Escherichia coli
2.7.1.11
additional information
-
pH-optimum depends on nucleoside triphosphate substrate
Saccharomyces cerevisiae
2.7.1.11
7.6
-
-
Fasciola hepatica
2.7.1.11
7.6
-
ITP, optima at pH 7.6 and pH 8.2
Saccharomyces cerevisiae
2.7.1.11
7.8
-
with ATP
Saccharomyces cerevisiae
2.7.1.11
8.2
-
ITP, optima at pH 7.6 and pH 8.2
Saccharomyces cerevisiae
pH Stability (protein specific)
EC Number
pH Stability
pH Stability Maximum
Commentary
Organism
2.7.1.11
additional information
-
heart enzyme, mild acidic conditions lead to reversible dissociation and decrease of activity, ATP or fructose 1,6-bisphosphate protects
Ovis aries
2.7.1.11
8
-
-
Oryctolagus cuniculus
2.7.1.11
8
-
relatively stable to inactivation by dilution, muscle enzyme
Ovis aries