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Literature summary extracted from

  • Rip, J.W.; Carroll, K.K.
    Properties of a dolichol phosphokinase activity associated with rat liver microsomes (1980), Can. J. Biochem., 58, 1051-1057.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.108 dithiothreitol slight stimulation of activity Rattus norvegicus
2.7.1.108 Triton X-100
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.108 CDP
-
 Rattus norvegicus
2.7.1.108 EDTA
-
 Rattus norvegicus
2.7.1.108 additional information product of the reaction, dolichyl phosphate, is noninhibitory, no inhibition by dithiothreitol Rattus norvegicus
2.7.1.108 Triton X-100 above 0.5% w/v, activation below Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.108 0.05
-
 dolichol pH 7.4, 37°C Rattus norvegicus
2.7.1.108 4
-
 CTP pH 7.4, 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.108 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.108 Ca2+
-
 Rattus norvegicus
2.7.1.108 Mg2+
-
 Rattus norvegicus
2.7.1.108 Mn2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.108 CTP + dolichol Rattus norvegicus
-
 CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol Rattus norvegicus Wistar
-
 CDP + dolichyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.108 Rattus norvegicus
-
 rat
-
2.7.1.108 Rattus norvegicus
-
 Wistar
-
2.7.1.108 Rattus norvegicus Wistar
-
 Wistar
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.108 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.108 CTP + dolichol
-
 Rattus norvegicus CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol
-
 Rattus norvegicus Wistar CDP + dolichyl phosphate
-
 ?
2.7.1.108 additional information ATP cannot replace CTP Rattus norvegicus ?
-
 ?
2.7.1.108 additional information ATP cannot replace CTP Rattus norvegicus Wistar ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.108 7 7.5
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.108 4 10 about half-maximal activity at pH 6.0 and 8.0 Rattus norvegicus