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Literature summary extracted from

  • Burton, W.A.; Scher, M.G.; Waechter, C.J.
    Enzymatic phosphorylation of dolichol in central nervous tissue (1979), J. Biol. Chem., 254, 7129-7136.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.108 2-mercaptoethanol slight stimulation Bos taurus
2.7.1.108 monothioglycerol slight stimulation Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.108 CDP end product inhibition Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.108 0.0065
-
 CTP pH 7.0, 37°C Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.108 membrane
-
 Bos taurus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.108 Ca2+
-
 Bos taurus
2.7.1.108 Mg2+
-
 Bos taurus
2.7.1.108 Mn2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.108 CTP + dolichol Bos taurus newly formed dolichyl monophosphate, phosphorylated via CTP is available for biosynthesis of mannosylphosphoryldolichol and N-acetylglucosaminylpyrophosphoryldolichol CDP + dolichyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.108 Bos taurus
-
 calf
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.108 brain
-
 Bos taurus
-

Storage Stability

EC Number Storage Stability Organism
2.7.1.108 -17°C, stable for at least 1 month Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.108 CTP + dolichol
-
 Bos taurus CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol newly formed dolichyl monophosphate, phosphorylated via CTP is available for biosynthesis of mannosylphosphoryldolichol and N-acetylglucosaminylpyrophosphoryldolichol Bos taurus CDP + dolichyl phosphate
-
 ?
2.7.1.108 additional information ATP and GTP are not effective substrates compared to CTP Bos taurus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.108 7
-
-
 Bos taurus