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Literature summary extracted from

  • Rose, I.A.; Warms, J.V.B.; Wong, L.J.
    Inhibitors of glucose-1,6-bisphosphate synthase (1977), J. Biol. Chem., 252, 4262-4268.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.106 cis/trans-aconitate
-
 Bos taurus
2.7.1.106 citrate
-
 Bos taurus
2.7.1.106 D-fructose 1,6-diphosphate
-
 Bos taurus
2.7.1.106 D-glucose 1,6-diphosphate
-
 Bos taurus
2.7.1.106 Glutarate weak Bos taurus
2.7.1.106 glycerate 2,3-diphosphate
-
 Bos taurus
2.7.1.106 Glycerate 3-phosphate
-
 Bos taurus
2.7.1.106 isocitrate
-
 Bos taurus
2.7.1.106 K+ weak Bos taurus
2.7.1.106 L-malate weak Bos taurus
2.7.1.106 Li+ strong, dilution, Co2+ or Zn2+ protects, not Ca2+, Mg2+ or Mn2+ Bos taurus
2.7.1.106 additional information no inhibition by adipate or succinate Bos taurus
2.7.1.106 Na+ weak Bos taurus
2.7.1.106 phosphate
-
 Bos taurus
2.7.1.106 phosphoenolpyruvate strong Bos taurus
2.7.1.106 tricarballylate
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.106 0.000087
-
 3-phospho-D-glyceroyl 1-phosphate 23°C, pH 8, Mg2+-enzyme in brain Bos taurus
2.7.1.106 0.000091
-
 3-phospho-D-glyceroyl 1-phosphate 23°C, pH 8, Zn2+-enzyme in brain Bos taurus
2.7.1.106 0.09
-
 D-glucose 1-phosphate 23°C, pH 8, Mg2+- and Zn2+-enzyme in brain Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.106 Co2+ tightly bound, can replace Zn2+ Bos taurus
2.7.1.106 Mg2+ no activation of enzyme in Zn-form Bos taurus
2.7.1.106 Mg2+ activation, easily dissociates from enzyme protein Bos taurus
2.7.1.106 Mg2+ Km-value: 1 mM Bos taurus
2.7.1.106 Zn2+ Zn-form of the enzyme: tightly bound, about 65% of brain enzyme in Zn-form Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.106 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.106 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
-
 Bos taurus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.106 25
-
 assay at Bos taurus