BRENDA - Enzyme Database

Inhibitors of glucose-1,6-bisphosphate synthase

Rose, I.A.; Warms, J.V.B.; Wong, L.J.; J. Biol. Chem. 252, 4262-4268 (1977)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.106
cis/trans-aconitate
-
Bos taurus
2.7.1.106
citrate
-
Bos taurus
2.7.1.106
D-fructose 1,6-diphosphate
-
Bos taurus
2.7.1.106
D-glucose 1,6-diphosphate
-
Bos taurus
2.7.1.106
Glutarate
weak
Bos taurus
2.7.1.106
glycerate 2,3-diphosphate
-
Bos taurus
2.7.1.106
Glycerate 3-phosphate
-
Bos taurus
2.7.1.106
isocitrate
-
Bos taurus
2.7.1.106
K+
weak
Bos taurus
2.7.1.106
L-malate
weak
Bos taurus
2.7.1.106
Li+
strong, dilution, Co2+ or Zn2+ protects, not Ca2+, Mg2+ or Mn2+
Bos taurus
2.7.1.106
additional information
no inhibition by adipate or succinate
Bos taurus
2.7.1.106
Na+
weak
Bos taurus
2.7.1.106
phosphate
-
Bos taurus
2.7.1.106
phosphoenolpyruvate
strong
Bos taurus
2.7.1.106
tricarballylate
-
Bos taurus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.1.106
0.000087
-
3-phospho-D-glyceroyl 1-phosphate
23°C, pH 8, Mg2+-enzyme in brain
Bos taurus
2.7.1.106
0.000091
-
3-phospho-D-glyceroyl 1-phosphate
23°C, pH 8, Zn2+-enzyme in brain
Bos taurus
2.7.1.106
0.09
-
D-glucose 1-phosphate
23°C, pH 8, Mg2+- and Zn2+-enzyme in brain
Bos taurus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.106
Co2+
tightly bound, can replace Zn2+
Bos taurus
2.7.1.106
Mg2+
activation, easily dissociates from enzyme protein; Km-value: 1 mM; no activation of enzyme in Zn-form
Bos taurus
2.7.1.106
Zn2+
Zn-form of the enzyme: tightly bound, about 65% of brain enzyme in Zn-form
Bos taurus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.106
Bos taurus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.106
brain
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.106
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
-
640350
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.7.1.106
25
-
assay at
Bos taurus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.106
cis/trans-aconitate
-
Bos taurus
2.7.1.106
citrate
-
Bos taurus
2.7.1.106
D-fructose 1,6-diphosphate
-
Bos taurus
2.7.1.106
D-glucose 1,6-diphosphate
-
Bos taurus
2.7.1.106
Glutarate
weak
Bos taurus
2.7.1.106
glycerate 2,3-diphosphate
-
Bos taurus
2.7.1.106
Glycerate 3-phosphate
-
Bos taurus
2.7.1.106
isocitrate
-
Bos taurus
2.7.1.106
K+
weak
Bos taurus
2.7.1.106
L-malate
weak
Bos taurus
2.7.1.106
Li+
strong, dilution, Co2+ or Zn2+ protects, not Ca2+, Mg2+ or Mn2+
Bos taurus
2.7.1.106
additional information
no inhibition by adipate or succinate
Bos taurus
2.7.1.106
Na+
weak
Bos taurus
2.7.1.106
phosphate
-
Bos taurus
2.7.1.106
phosphoenolpyruvate
strong
Bos taurus
2.7.1.106
tricarballylate
-
Bos taurus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.1.106
0.000087
-
3-phospho-D-glyceroyl 1-phosphate
23°C, pH 8, Mg2+-enzyme in brain
Bos taurus
2.7.1.106
0.000091
-
3-phospho-D-glyceroyl 1-phosphate
23°C, pH 8, Zn2+-enzyme in brain
Bos taurus
2.7.1.106
0.09
-
D-glucose 1-phosphate
23°C, pH 8, Mg2+- and Zn2+-enzyme in brain
Bos taurus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.106
Co2+
tightly bound, can replace Zn2+
Bos taurus
2.7.1.106
Mg2+
activation, easily dissociates from enzyme protein; Km-value: 1 mM; no activation of enzyme in Zn-form
Bos taurus
2.7.1.106
Zn2+
Zn-form of the enzyme: tightly bound, about 65% of brain enzyme in Zn-form
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.106
brain
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.106
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
-
640350
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.7.1.106
25
-
assay at
Bos taurus