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Literature summary extracted from

  • Ueda, M.; Hirose, M.; Sasaki, R.; Chiba, H.
    Regulation of glucose 1,6-bisphosphate level in liver. III. Purification and properties of bovine glucose 1,6-bisphosphate synthase (1978), J. Biochem., 83, 1721-1730.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.106 D-fructose 1,6-diphosphate strong, liver Bos taurus
2.7.1.106 glycerate 2,3-diphosphate strong, liver Bos taurus
2.7.1.106 phosphoenolpyruvate strong Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.106 0.00023
-
 3-phospho-D-glyceroyl 1-phosphate 25°C, pH 7.5, liver enzyme peak I Bos taurus
2.7.1.106 0.00028
-
 3-phospho-D-glyceroyl 1-phosphate 25°C, pH 7.5, liver enzyme peak II Bos taurus
2.7.1.106 0.00045
-
 3-phospho-D-glyceroyl 1-phosphate 25°C, pH 7.5, erythrocyte enzyme Bos taurus
2.7.1.106 0.009
-
 D-glucose 1-phosphate 25°C, pH 7.5, liver enzyme peak I Bos taurus
2.7.1.106 0.015
-
 D-glucose 6-phosphate 25°C, pH 7.5, liver enzyme peak I Bos taurus
2.7.1.106 0.059
-
 D-glucose 1-phosphate 25°C, pH 7.5, liver enzyme peak II Bos taurus
2.7.1.106 0.061
-
 D-glucose 6-phosphate 25°C, pH 7.5, liver enzyme peak II Bos taurus
2.7.1.106 0.16
-
 D-glucose 1-phosphate 25°C, pH 7.5, erythrocyte enzyme Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.106 soluble
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.106 Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate Bos taurus
-
 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.106 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.106 liver: 2 isozymes Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.106 erythrocyte
-
 Bos taurus
-
2.7.1.106 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.106 0.0045
-
 liver enzyme Bos taurus
2.7.1.106 0.136
-
 erythrocyte enzyme Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
-
 Bos taurus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate i.e. 1,3-diphosphoglycerate Bos taurus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate specific for 3-phospho-D-glyceroyl phosphate Bos taurus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate no acceptor activity mannose 6-phosphate Bos taurus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 6-phosphate
-
 Bos taurus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 ?
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-mannose 1-phosphate
-
 Bos taurus 3-phospho-D-glycerate + D-mannose 1,6-bisphosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.106 25
-
 assay at Bos taurus