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Literature summary extracted from

  • Rose, I.A.; Warms, J.V.B.; Kaklij, G.
    A specific enzyme for glucose 1,6-bisphosphate synthesis (1975), J. Biol. Chem., 250, 3466-3470.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.106 acetyl-CoA
-
 Mus musculus
2.7.1.106 D-fructose 1,6-diphosphate
-
 Mus musculus
2.7.1.106 D-glucose 1,6-diphosphate
-
 Mus musculus
2.7.1.106 glycerate 2,3-diphosphate
-
 Mus musculus
2.7.1.106 Glycerate 3-phosphate weak Mus musculus
2.7.1.106 Imidazole/EDTA
-
 Mus musculus
2.7.1.106 phosphate
-
 Mus musculus
2.7.1.106 phosphoenolpyruvate strong Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.106 soluble
-
 Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.106 Ca2+ requirement, can be replaced by Mg2+, Mn2+, Zn2+, Ni2+, Co2+, Cd2+ Mus musculus
2.7.1.106 Cd2+ requirement, can be replaced by Mg2+, Mn2+, Ca2+, Zn2+, Ni2+, Co2+ Mus musculus
2.7.1.106 Co2+ requirement, can be replaced by Mg2+, Mn2+, Ca2+, Zn2+, Ni2+, Cd2+ Mus musculus
2.7.1.106 Mg2+ requirement, can be replaced by Mn2+, Ca2+, Zn2+, Ni2+, Co2+, Cd2+ Mus musculus
2.7.1.106 Mn2+ requirement, can be replaced by Mg2+, Ca2+, Zn2+, Ni2+, Co2+, Cd2+ Mus musculus
2.7.1.106 Ni2+ requirement, can be replaced by Mg2+, Mn2+, Ca2+, Zn2+, Co2+, Cd2+ Mus musculus
2.7.1.106 Zn2+ requirement, can be replaced by Mg2+, Mn2+, Ca2+, Ni2+, Co2+, Cd2+ Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate Mus musculus responsible for glucose 1,6-diphosphate biosynthesis in brain 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.106 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.106 partial Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.106 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate i.e. 1,3-diphosphoglycerate Mus musculus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate no phosphoryl donors are acetyl phosphate, ATP, phosphoenolpyruvate, creatine phosphate, fructose 1,6-diphosphate Mus musculus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate little or no acceptor activity: glucose, glucose 6-sulfate, glucosamine 6-phosphate, 2-deoxy-glucose 6-phosphate, 3-phosphoglycerate, galactose or fructose monophosphates Mus musculus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate no acceptor activity mannose 6-phosphate Mus musculus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate responsible for glucose 1,6-diphosphate biosynthesis in brain Mus musculus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 r
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-glucose 6-phosphate phosphorylation at 56% the rate of glucose 1-phosphate Mus musculus 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
 ?
2.7.1.106 3-phospho-D-glyceroyl phosphate + D-mannose 1-phosphate phosphorylation at 81% the rate of glucose 1-phosphate Mus musculus 3-phospho-D-glycerate + D-mannose 1,6-bisphosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.106 25
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.106 8
-
-
 Mus musculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.106 7.3 8.7 about half-maximal activity at pH 7.3 and 8.7 Mus musculus