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Literature summary extracted from

  • Chesney, J.; Mitchell, R.; Benigni, F.; Bacher, M.; Spiegel, L.; Al-Abed, Y.; Han, J.H.; Metz, C.; Bucala, R.
    An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect (1999), Proc. Natl. Acad. Sci. USA, 96, 3047-3052.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.105 isoform of enzyme that is induced by proinflammatory stimuli and that is distinguished by the presence of multiple copies of the AUUUA instability motif in its 3' untranslated region is identified and the complete cDNA is cloned and sequenced, expression in eigth human tumor cell lines Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate Homo sapiens the inducible enzyme is an important regulator of glycolysis that may be responsible for sustaining the high glycolytic flux of rapidly proliferating leukemia cells ADP + beta-D-fructose 2,6-bisphosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.105 Faxonius limosus
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 crayfish
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2.7.1.105 Homo sapiens Q16875
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.105 midgut gland Faxonius limosus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
 Homo sapiens ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
2.7.1.105 ATP + beta-D-fructose 6-phosphate the inducible enzyme is an important regulator of glycolysis that may be responsible for sustaining the high glycolytic flux of rapidly proliferating leukemia cells Homo sapiens ADP + beta-D-fructose 2,6-bisphosphate
-
 ?