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Literature summary extracted from

  • Rider, M.H.
    Regulation of fructose-2,6-bisphosphate synthesis and breakdown in heart and skeletal muscle (1987), Biochem. Soc. Trans., 15, 988-991.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.105 citrate
-
 Bos taurus
2.7.1.105 citrate skeletal muscle enzyme is more sensitive than liver enzyme Columba sp.
2.7.1.105 citrate skeletal muscle enzyme is more sensitive than liver enzyme Rattus norvegicus
2.7.1.105 additional information no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme Bos taurus
2.7.1.105 additional information no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Columba sp.
2.7.1.105 additional information no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme Rattus norvegicus
2.7.1.105 phosphoenolpyruvate
-
 Bos taurus
2.7.1.105 phosphoenolpyruvate
-
 Rattus norvegicus
2.7.1.105 sn-glycerol 3-phosphate heart enzyme is less sensitive than liver Bos taurus
2.7.1.105 sn-glycerol 3-phosphate heart enzyme is less sensitive than liver; liver enzyme Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.105 Mg2+
-
 Rattus norvegicus
2.7.1.105 Mg2+
-
 Bos taurus
2.7.1.105 Mg2+
-
 Columba sp.
2.7.1.105 phosphate
-
 Bos taurus
2.7.1.105 phosphate
-
 Columba sp.
2.7.1.105 phosphate liver enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate Rattus norvegicus responsible for regulation of fructose 2,6-bisphosphate-concentration ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
2.7.1.105 ATP + beta-D-fructose 6-phosphate Bos taurus responsible for regulation of fructose 2,6-bisphosphate-concentration ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
2.7.1.105 ATP + beta-D-fructose 6-phosphate Columba sp. responsible for regulation of fructose 2,6-bisphosphate-concentration ADP + beta-D-fructose 2,6-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.105 Bos taurus
-
-
-
2.7.1.105 Columba sp.
-
-
-
2.7.1.105 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.105 phosphoprotein rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme Rattus norvegicus
2.7.1.105 phosphoprotein rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme Bos taurus
2.7.1.105 phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Rattus norvegicus
2.7.1.105 phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Bos taurus
2.7.1.105 phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Columba sp.

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.105 ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Rattus norvegicus
a
2.7.1.105 ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.105 heart
-
 Rattus norvegicus
-
2.7.1.105 heart two isozymic forms Bos taurus
-
2.7.1.105 liver
-
 Rattus norvegicus
-
2.7.1.105 liver
-
 Bos taurus
-
2.7.1.105 skeletal muscle
-
 Rattus norvegicus
-
2.7.1.105 skeletal muscle
-
 Columba sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
 Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 r
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
 Bos taurus ADP + beta-D-fructose 2,6-bisphosphate
-
 r
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
 Columba sp. ADP + beta-D-fructose 2,6-bisphosphate
-
 r
2.7.1.105 ATP + beta-D-fructose 6-phosphate responsible for regulation of fructose 2,6-bisphosphate-concentration Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
2.7.1.105 ATP + beta-D-fructose 6-phosphate responsible for regulation of fructose 2,6-bisphosphate-concentration Bos taurus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
2.7.1.105 ATP + beta-D-fructose 6-phosphate responsible for regulation of fructose 2,6-bisphosphate-concentration Columba sp. ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
2.7.1.105 additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Rattus norvegicus ?
-
 ?
2.7.1.105 additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Bos taurus ?
-
 ?
2.7.1.105 additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Columba sp. ?
-
 ?
2.7.1.105 additional information with discrete catalytic sites Rattus norvegicus ?
-
 ?
2.7.1.105 additional information with discrete catalytic sites Bos taurus ?
-
 ?
2.7.1.105 additional information with discrete catalytic sites Columba sp. ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.105 AMP
-
 Rattus norvegicus
2.7.1.105 AMP
-
 Bos taurus
2.7.1.105 AMP
-
 Columba sp.