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Literature summary extracted from

  • Pilkis, S.J.; Pilkis, J.; El-Maghrabi, M.R.; Claus, T.H.
    The sugar phosphate specificity of rat hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (1985), J. Biol. Chem., 260, 7551-7556.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.105 2,5-anhydro-D-mannitol 6-phosphate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.105 0.035
-
 beta-D-fructose 6-phosphate pH 7.5, 30°C Rattus norvegicus
2.7.1.105 0.175
-
 L-Sorbose 6-phosphate pH 7.5, 30°C Rattus norvegicus
2.7.1.105 7.4
-
 D-psicose 6-phosphate pH 7.5, 30°C Rattus norvegicus
2.7.1.105 15
-
 D-tagatose 6-phosphate pH 7.5, 30°C Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.105 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.105 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate sugar phosphate specificity Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
2.7.1.105 ATP + beta-D-fructose 6-phosphate not: ribose 5-phosphate Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
2.7.1.105 ATP + beta-D-fructose 6-phosphate not: 1-O-methyl-D-fructose 6-phosphate, alpha-/beta-methyl-D-fructofuranoside 6-phosphate, 2,5-anhydro-D-mannitol 6-phosphate, D-arabinose 5-phosphate Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
2.7.1.105 ATP + D-psicose 6-phosphate
-
 Rattus norvegicus ?
-
 ?
2.7.1.105 ATP + D-tagatose 6-phosphate
-
 Rattus norvegicus ?
-
 ?
2.7.1.105 ATP + L-sorbose 6-phosphate
-
 Rattus norvegicus ?
-
 ?
2.7.1.105 additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Rattus norvegicus ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.105 0.095
-
 2,5-anhydro-D-mannitol 6-phosphate pH 7.5, 30°C Rattus norvegicus