Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cesar, M.deC.; Wilson, J.E.
    Functional characteristics of hexokinase bound to the type A and type B sites of bovine brain mitochondria (2002), Arch. Biochem. Biophys., 397, 106-112.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 1,5-Anhydro-D-glucitol 6-phosphate hexokinase bound at type A and type B sites of brain mitochondria is relatively insensitive, hexokinase bound at type B sites, after removal of enzyme of type A sites, shows increased sensitivity Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.1 mitochondrion bound at type A sites and type B sites of brain mitochondria, ratio of type A:type B is 40:60, enzyme bound at type A sites is releaved by glucose 6-phosphate, but not that of type B sites Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.1 D-glucose + ATP Bos taurus cerebral glycolytic metabolism, mechanisms for regulation of mitochondrial hexokinase activity may depend on the ratio of type A:type B sites D-glucose 6-phosphate + ADP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 D-glucose + ATP hexokinase bound at type A and B sites of brain mitochondria selectively uses intramitochondrial ATP as substrate, but hexokinase bound at type B sites, after removal of enzyme of type A sites, shows no such selectivity Bos taurus ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 D-glucose + ATP cerebral glycolytic metabolism, mechanisms for regulation of mitochondrial hexokinase activity may depend on the ratio of type A:type B sites Bos taurus D-glucose 6-phosphate + ADP
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.1 ATP
-
 Bos taurus