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Literature summary extracted from

  • Nemat-Gorgani, M.; Wilson, J.E.
    Acidic phospholipids may inhibit rat brain hexokinase by interaction at the nucleotide binding site (1985), Arch. Biochem. Biophys., 236, 220-227.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 acidic phospholipids irreversible inhibition, binds at the nucleotide-binding site of enzyme, ATP and glucose 6-phosphate protect, effectiveness of various ligands in protection against inhibition, effect of pH and temperature Rattus norvegicus
2.7.1.1 cardiolipin effectiveness of various ligands in protection against inhibition, effect of pH and temperature Rattus norvegicus
2.7.1.1 Cibacron blue competitive to ATP Rattus norvegicus
2.7.1.1 D-glucose 6-phosphate reversible product inhibition Rattus norvegicus
2.7.1.1 additional information not inhibited by 1 mM phosphatidylethanolamine or phosphatidylcholine Rattus norvegicus
2.7.1.1 phosphatidylinositol effectiveness of various ligands in protection against inhibition, effect of pH and temperature Rattus norvegicus
2.7.1.1 phosphatidylserine
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.1 mitochondrial outer membrane binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo Rattus norvegicus 5741
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.1 D-glucose + ATP Rattus norvegicus binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo, and thereby of the cerebral glycolytic rate D-glucose 6-phosphate + ADP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.1
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 D-glucose + ATP
-
Rattus norvegicus ADP + D-glucose 6-phosphate
-
?
2.7.1.1 D-glucose + ATP binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo, and thereby of the cerebral glycolytic rate Rattus norvegicus D-glucose 6-phosphate + ADP
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.1 ATP
-
Rattus norvegicus