EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.1 | acidic phospholipids | irreversible inhibition, binds at the nucleotide-binding site of enzyme, ATP and glucose 6-phosphate protect, effectiveness of various ligands in protection against inhibition, effect of pH and temperature | Rattus norvegicus | |
2.7.1.1 | cardiolipin | effectiveness of various ligands in protection against inhibition, effect of pH and temperature | Rattus norvegicus | |
2.7.1.1 | Cibacron blue | competitive to ATP | Rattus norvegicus | |
2.7.1.1 | D-glucose 6-phosphate | reversible product inhibition | Rattus norvegicus | |
2.7.1.1 | additional information | not inhibited by 1 mM phosphatidylethanolamine or phosphatidylcholine | Rattus norvegicus | |
2.7.1.1 | phosphatidylinositol | effectiveness of various ligands in protection against inhibition, effect of pH and temperature | Rattus norvegicus | |
2.7.1.1 | phosphatidylserine | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.1 | mitochondrial outer membrane | binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo | Rattus norvegicus | 5741 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.1 | D-glucose + ATP | Rattus norvegicus | binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo, and thereby of the cerebral glycolytic rate | D-glucose 6-phosphate + ADP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.1 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.1 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.1 | brain | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.1 | D-glucose + ATP | - |
Rattus norvegicus | ADP + D-glucose 6-phosphate | - |
? | |
2.7.1.1 | D-glucose + ATP | binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo, and thereby of the cerebral glycolytic rate | Rattus norvegicus | D-glucose 6-phosphate + ADP | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.1 | ATP | - |
Rattus norvegicus |