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Literature summary extracted from

  • Vandercammen, A.; Van Schaftingen, E.
    Competitive inhibition of liver glucokinase by its regulatory protein (1991), Eur. J. Biochem., 200, 545-551.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 acetate noncompetitive to glucose Rattus norvegicus
2.7.1.1 Br- noncompetitive to glucose Rattus norvegicus
2.7.1.1 Cl- noncompetitive to glucose Rattus norvegicus
2.7.1.1 F- noncompetitive to glucose Rattus norvegicus
2.7.1.1 I- noncompetitive to glucose Rattus norvegicus
2.7.1.1 additional information enzymes from rat brain and bovine heart are not inhibited by palmitoyl-CoA or regulatory protein Bos taurus
2.7.1.1 additional information enzymes from rat brain and bovine heart are not inhibited by palmitoyl-CoA or regulatory protein Rattus norvegicus
2.7.1.1 additional information
-
 Sus scrofa
2.7.1.1 N-acetyl-D-glucosamine
-
 Rattus norvegicus
2.7.1.1 NO3- noncompetitive to glucose Rattus norvegicus
2.7.1.1 palmitoyl-CoA inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast; inhibitor binds to a site distinct from the catalytic site, noncompetitive to MgATP2-, competitive to glucose, synergistic with N-acetylglucosamine Rattus norvegicus
2.7.1.1 palmitoyl-CoA inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast Rhinella marina
2.7.1.1 palmitoyl-CoA inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast Sus scrofa
2.7.1.1 phosphate noncompetitive to glucose Rattus norvegicus
2.7.1.1 phosphate
-
 Sus scrofa
2.7.1.1 Regulatory protein inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast; inhibitor binds to a site distinct from the catalytic site, noncompetitive to MgATP2-, competitive to glucose, synergistic with N-acetylglucosamine, phosphate and sulfate decrease inhibition, monovalent anions antagonize inhibition with the following decreasing order of potency: I-, Br-, NO3-, Cl-, F-, acetate Rattus norvegicus
2.7.1.1 Regulatory protein inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast Rhinella marina
2.7.1.1 Regulatory protein inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast Sus scrofa
2.7.1.1 SO42- noncompetitive to glucose Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.1 0.1
-
 2-deoxy-D-glucose rat brain enzyme, hexokinase I Rattus norvegicus
2.7.1.1 0.125
-
 2-deoxy-D-glucose
-
 Bos taurus
2.7.1.1 0.125
-
 2-deoxy-D-glucose bovine heart enzyme, hexokinase II Rattus norvegicus
2.7.1.1 5.5
-
 D-glucose hexokinase IV Sus scrofa
2.7.1.1 9
-
 2-deoxy-D-glucose rat liver enzyme, hexokinase IV Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Bos taurus
-
 hexokinase II
-
2.7.1.1 Rattus norvegicus
-
 hexokinase IV or D
-
2.7.1.1 Rhinella marina
-
-
-
2.7.1.1 Sus scrofa
-
 hexokinase IV
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.1
-
 Rattus norvegicus
2.7.1.1
-
 Sus scrofa
2.7.1.1
-
 Rhinella marina

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 heart
-
 Bos taurus
-
2.7.1.1 liver
-
 Sus scrofa
-
2.7.1.1 liver hexokinase IV or D Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 ATP + 2-deoxy-D-glucose
-
 Rattus norvegicus ADP + 2-deoxy-D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + 2-deoxy-D-glucose
-
 Sus scrofa ADP + 2-deoxy-D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + 2-deoxy-D-glucose
-
 Bos taurus ADP + 2-deoxy-D-glucose 6-phosphate
-
 ?
2.7.1.1 D-glucose + ATP
-
 Rattus norvegicus ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 D-glucose + ATP
-
 Sus scrofa ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 D-glucose + ATP
-
 Bos taurus ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 D-glucose + ATP
-
 Rhinella marina ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 D-mannose + ATP
-
 Rattus norvegicus ADP + D-mannose 6-phosphate
-
 ?
2.7.1.1 D-mannose + ATP
-
 Sus scrofa ADP + D-mannose 6-phosphate
-
 ?
2.7.1.1 additional information
-
 Sus scrofa ?
-
 ?
2.7.1.1 additional information not: D-galactose Rattus norvegicus ?
-
 ?
2.7.1.1 additional information not: trehalose Rattus norvegicus ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.1 ATP
-
 Rattus norvegicus
2.7.1.1 ATP
-
 Sus scrofa
2.7.1.1 ATP
-
 Bos taurus
2.7.1.1 ATP
-
 Rhinella marina

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.1 0.0035
-
 palmitoyl-CoA
-
 Rattus norvegicus
2.7.1.1 1.6
-
 palmitoyl-CoA
-
 Sus scrofa