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Literature summary extracted from

  • Tahira, A.A.; Nakano, M.; Funayama, S.; Veiga, L.A.
    Purification and properties of hexokinase from Trypanosoma cruzi (1980), Arq. Biol. Tecnol. (Curitiba), 23, 283-294.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 ADP
-
 Trypanosoma cruzi
2.7.1.1 D-glucose 6-phosphate
-
 Trypanosoma cruzi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.1 additional information
-
 additional information
-
 Trypanosoma cruzi
2.7.1.1 0.85
-
 D-mannose
-
 Trypanosoma cruzi
2.7.1.1 1
-
 D-fructose
-
 Trypanosoma cruzi

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.1 Mg2+ absolute requirement for Mg2+ and ATP Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Trypanosoma cruzi
-
 hexokinase I
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.1 hexokinase I, 103fold Trypanosoma cruzi

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 epimastigote
-
 Trypanosoma cruzi
-

Storage Stability

EC Number Storage Stability Organism
2.7.1.1 at least 3 months, stable Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 D-fructose + ATP
-
 Trypanosoma cruzi ADP + D-fructose 6-phosphate
-
 ?
2.7.1.1 D-glucose + ATP most active with D-glucose Trypanosoma cruzi ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 D-mannose + ATP
-
 Trypanosoma cruzi ADP + D-mannose 6-phosphate
-
 ?
2.7.1.1 GTP + D-glucose can partially replace ATP Trypanosoma cruzi GDP + D-glucose 6-phosphate
-
 ?
2.7.1.1 UTP + D-glucose can partially replace ATP Trypanosoma cruzi UDP + D-glucose 6-phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.1 37
-
 assay at Trypanosoma cruzi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.1 6.5
-
 optimal activity at pH 6.5 and 9.0 at 37°C Trypanosoma cruzi
2.7.1.1 9
-
 optimal activity at pH 6.5 and 9.0 at 37°C Trypanosoma cruzi

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.1 ATP absolute requirement for Mg2+ and ATP Trypanosoma cruzi

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.1 0.13
-
 ADP
-
 Trypanosoma cruzi
2.7.1.1 1.4
-
 D-glucose 6-phosphate
-
 Trypanosoma cruzi