Literature summary extracted from

Walker, J.B.; Walker, M.S.
Streptomycin biosynthesis. Transamination reactions involving inosamines and inosadiamines (1969), Biochemistry, 8, 763-770.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.6.1.56	L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol	Streptomyces bikiniensis	streptomycin biosynthesis	pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.6.1.56	Streptomyces bikiniensis	-	ATCC 11062	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.6.1.56	L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol	-	Streptomyces bikiniensis	pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol	-	r
2.6.1.56	L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol	streptomycin biosynthesis	Streptomyces bikiniensis	pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol	-	r
2.6.1.56	L-glutamate + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol	-	Streptomyces bikiniensis	5-amino-2,5-dioxopentanoic acid + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol	-	r
2.6.1.56	L-glutamine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol	-	Streptomyces bikiniensis	alpha-ketoglutaramate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol	-	ir

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.6.1.56	pyridoxal 5'-phosphate	-	Streptomyces bikiniensis

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Release 2023.1 (January 2023)