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Literature summary extracted from

  • Baek, J.Y.; Jun do, Y.; Taub, D.; Kim, Y.H.
    Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of L-serine biosynthesis (2003), Biochem. J., 373, 191-200.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.6.1.52 medicine useful for creating a new concept or target for the diagnosis and therapy of human serine metabolism-related disorders and cancer Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.52 2 forms results from alternative splicing, PSATalpha and PSATbeta, cDNA cloned and expressed in Escherichia coli and in human cell lines, leukaemia Jurkat, colon adenocarcinoma COLO 320DM, heptacellular carcinoma HepG2 and weakly in leukaemia MOLT-3, complementation of Saccharomyces cerevisiae SER-1 deletion mutation Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.52 35200
-
 PSATalpha, predicted from cDNA Homo sapiens
2.6.1.52 40000
-
 PSATbeta, predicted from cDNA Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.52 L-glutamate + 3-phosphohydroxypyruvate Homo sapiens phosphorylated pathway for serine biosynthesis O-phospho-L-serine + 2-oxoglutarate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.52 Homo sapiens Q9Y617
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.52 brain mRNA expressed in Homo sapiens
-
2.6.1.52 kidney mRNA expressed in Homo sapiens
-
2.6.1.52 liver mRNA expressed in Homo sapiens
-
2.6.1.52 additional information very weak mRNA expression in thymus,prostate, testis and colon Homo sapiens
-
2.6.1.52 pancreas mRNA expressed in Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.52 L-glutamate + 3-phosphohydroxypyruvate
-
 Homo sapiens O-phospho-L-serine + 2-oxoglutarate
-
 r
2.6.1.52 L-glutamate + 3-phosphohydroxypyruvate phosphorylated pathway for serine biosynthesis Homo sapiens O-phospho-L-serine + 2-oxoglutarate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.6.1.52 PSAT alpha
-
 Homo sapiens
2.6.1.52 PSAT beta
-
 Homo sapiens