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Literature summary extracted from

  • Basurko, M.J.; Marche, M.; Darriet, M.; Cassaigne, A.
    Phosphoserine aminotransferase, the second step-catalyzing enzyme for serine biosynthesis (1999), IUBMB Life, 48, 525-529.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.52 2-oxoglutarate
-
 Bos taurus
2.6.1.52 L-glutamate
-
 Bos taurus
2.6.1.52 L-phosphoserine product inhibition Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.52 0.005
-
 3-phosphohydroxypyruvate pH 7.5, 30°C Bos taurus
2.6.1.52 0.035
-
 L-phosphoserine pH 7.5, 30°C Bos taurus
2.6.1.52 0.8
-
 2-oxoglutarate pH 7.5, 30°C Bos taurus
2.6.1.52 1.2
-
 L-glutamate pH 7.5, 30°C Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.52 43000
-
 2 * 43000, SDS-PAGE Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.52 Bos taurus
-
 bovine
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.52
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.52 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.52 15
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.52 L-glutamate + 3-phosphohydroxypyruvate
-
 Bos taurus O-phospho-L-serine + 2-oxoglutarate
-
 r

Subunits

EC Number Subunits Comment Organism
2.6.1.52 dimer 2 * 43000, SDS-PAGE Bos taurus

Synonyms

EC Number Synonyms Comment Organism
2.6.1.52 PSerAT
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.52 pyridoxal 5'-phosphate Km 0.005 mM Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.52 0.045
-
 L-phosphoserine pH 7.5, 30°C Bos taurus
2.6.1.52 2.55
-
 2-oxoglutarate pH 7.5, 30°C Bos taurus
2.6.1.52 7.42
-
 L-glutamate pH 7.5, 30°C Bos taurus