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Literature summary extracted from

  • Noguchi, T.; Takada, Y.; Kido, R.
    Characteristics of hepatic serine-pyruvate aminotransferase in different mammalian species (1977), Biochem. J., 161, 609-614.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.51 hydroxylamine
-
Canis lupus familiaris
2.6.1.51 hydroxylamine
-
Felis catus
2.6.1.51 hydroxylamine
-
Mus musculus
2.6.1.51 hydroxylamine
-
Rattus norvegicus
2.6.1.51 Isonicotinic acid hydrazide
-
Mus musculus
2.6.1.51 Isonicotinic acid hydrazide
-
Rattus norvegicus
2.6.1.51 additional information not inhibited by isonicotinic acid hydrazide Canis lupus familiaris
2.6.1.51 additional information not inhibited by isonicotinic acid hydrazide Felis catus
2.6.1.51 Semicarbazide
-
Canis lupus familiaris
2.6.1.51 Semicarbazide
-
Felis catus
2.6.1.51 Semicarbazide
-
Mus musculus
2.6.1.51 Semicarbazide
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.51 1
-
pyruvate pH 8.0, 37°C, serine as amino donor Rattus norvegicus
2.6.1.51 1.2
-
pyruvate pH 8.0, 37°C, serine as amino donor Mus musculus
2.6.1.51 1.6
-
pyruvate pH 8.0, 37°C, serine as amino donor Felis catus
2.6.1.51 1.7
-
pyruvate pH 8.0, 37°C, serine as amino donor Canis lupus familiaris
2.6.1.51 8
-
serine pH 8.0, 37°C, pyruvate as amino acceptor Canis lupus familiaris
2.6.1.51 10
-
serine pH 8.0, 37°C, pyruvate as amino acceptor Felis catus
2.6.1.51 16
-
serine pH 8.0, 37°C, pyruvate as amino acceptor Rattus norvegicus
2.6.1.51 18
-
serine pH 8.0, 37°C, pyruvate as amino acceptor Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.51 mitochondrion
-
Rattus norvegicus 5739
-
2.6.1.51 mitochondrion
-
Canis lupus familiaris 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.51 73000 79000 sucrose density gradient centrifugation Mus musculus
2.6.1.51 73000 79000 sucrose density gradient centrifugation Rattus norvegicus
2.6.1.51 73000 79000 sucrose density gradient centrifugation Canis lupus familiaris
2.6.1.51 73000 79000 sucrose density gradient centrifugation Felis catus
2.6.1.51 75000 80000 gel filtration Mus musculus
2.6.1.51 75000 80000 gel filtration Rattus norvegicus
2.6.1.51 75000 80000 gel filtration Canis lupus familiaris
2.6.1.51 75000 80000 gel filtration Felis catus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.51 L-serine + pyruvate Mus musculus gluconeogenesis from serine 3-hydroxypyruvate + L-alanine
-
r
2.6.1.51 L-serine + pyruvate Rattus norvegicus gluconeogenesis from serine 3-hydroxypyruvate + L-alanine
-
r
2.6.1.51 L-serine + pyruvate Canis lupus familiaris gluconeogenesis from serine 3-hydroxypyruvate + L-alanine
-
r
2.6.1.51 L-serine + pyruvate Felis catus gluconeogenesis from serine 3-hydroxypyruvate + L-alanine
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.51 Canis lupus familiaris
-
dog
-
2.6.1.51 Felis catus
-
-
-
2.6.1.51 Mus musculus
-
mouse
-
2.6.1.51 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.51
-
Mus musculus
2.6.1.51
-
Rattus norvegicus
2.6.1.51
-
Canis lupus familiaris
2.6.1.51
-
Felis catus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.51 liver
-
Mus musculus
-
2.6.1.51 liver
-
Rattus norvegicus
-
2.6.1.51 liver
-
Canis lupus familiaris
-
2.6.1.51 liver
-
Felis catus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.51 2.02
-
alanine-hydroxypyruvate transamination Rattus norvegicus
2.6.1.51 2.23
-
alanine-hydroxypyruvate transamination Mus musculus
2.6.1.51 3.58
-
serine-pyruvate transamination Mus musculus
2.6.1.51 4.08
-
serine-pyruvate transamination Rattus norvegicus
2.6.1.51 13
-
serine-pyruvate transamination Canis lupus familiaris
2.6.1.51 13.12
-
-
Canis lupus familiaris
2.6.1.51 14
-
serine-pyruvate transamination Felis catus
2.6.1.51 16.63
-
alanine-hydroxypyruvate transamination Felis catus
2.6.1.51 31.38
-
alanine-hydroxypyruvate transamination Canis lupus familiaris

Storage Stability

EC Number Storage Stability Organism
2.6.1.51 -20°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, may be stored for at least 4 weeks without loss of activity Mus musculus
2.6.1.51 -20°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, may be stored for at least 4 weeks without loss of activity Canis lupus familiaris
2.6.1.51 -20°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, may be stored for at least 4 weeks without loss of activity Felis catus
2.6.1.51 0-6°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, little loss with storage for at least 2 weeks Mus musculus
2.6.1.51 0-6°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, little loss with storage for at least 2 weeks Canis lupus familiaris
2.6.1.51 0-6°C, 50 mM potassium phosphate buffer, pH 7.5, containing 0.1 M pyridoxal 5'-phosphate, little loss with storage for at least 2 weeks Felis catus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.51 5-hydroxytryptophan + pyruvate
-
Mus musculus 3-(5-hydroxyindole)-2-oxopropanoate + alanine
-
?
2.6.1.51 5-hydroxytryptophan + pyruvate
-
Rattus norvegicus 3-(5-hydroxyindole)-2-oxopropanoate + alanine
-
?
2.6.1.51 asparagine + pyruvate
-
Mus musculus 2-oxosuccinamate + L-alanine
-
?
2.6.1.51 asparagine + pyruvate
-
Rattus norvegicus 2-oxosuccinamate + L-alanine
-
?
2.6.1.51 glutamine + pyruvate
-
Mus musculus 4-carbamoyl-2-oxobutanoate + L-alanine
-
?
2.6.1.51 glutamine + pyruvate
-
Rattus norvegicus 4-carbamoyl-2-oxobutanoate + L-alanine
-
?
2.6.1.51 histidine + pyruvate
-
Mus musculus 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
?
2.6.1.51 histidine + pyruvate
-
Rattus norvegicus 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
?
2.6.1.51 isoleucine + pyruvate
-
Mus musculus 3-methyl-2-oxopentanoate + alanine
-
?
2.6.1.51 L-alanine + 3-hydroxypyruvate
-
Mus musculus pyruvate + L-serine
-
r
2.6.1.51 L-alanine + 3-hydroxypyruvate
-
Rattus norvegicus pyruvate + L-serine
-
r
2.6.1.51 L-alanine + 3-hydroxypyruvate
-
Canis lupus familiaris pyruvate + L-serine
-
r
2.6.1.51 L-leucine + phenylpyruvate
-
Mus musculus 4-methyl-2-oxopentanoate + L-phenylalanine
-
?
2.6.1.51 L-leucine + phenylpyruvate
-
Rattus norvegicus 4-methyl-2-oxopentanoate + L-phenylalanine
-
?
2.6.1.51 L-methionine + pyruvate
-
Mus musculus 4-methylsulfanyl-2-oxobutanoate + L-alanine
-
?
2.6.1.51 L-methionine + pyruvate
-
Rattus norvegicus 4-methylsulfanyl-2-oxobutanoate + L-alanine
-
?
2.6.1.51 L-phenylalanine + pyruvate
-
Mus musculus phenylpyruvate + L-alanine
-
?
2.6.1.51 L-phenylalanine + pyruvate
-
Rattus norvegicus phenylpyruvate + L-alanine
-
?
2.6.1.51 L-serine + glyoxylate
-
Mus musculus glycine + 3-hydroxypyruvate
-
r
2.6.1.51 L-serine + glyoxylate
-
Rattus norvegicus glycine + 3-hydroxypyruvate
-
r
2.6.1.51 L-serine + glyoxylate
-
Canis lupus familiaris glycine + 3-hydroxypyruvate
-
r
2.6.1.51 L-serine + glyoxylate
-
Felis catus glycine + 3-hydroxypyruvate
-
r
2.6.1.51 L-serine + phenylpyruvate
-
Mus musculus 3-hydroxypyruvate + L-phenylalanine
-
r
2.6.1.51 L-serine + phenylpyruvate
-
Rattus norvegicus 3-hydroxypyruvate + L-phenylalanine
-
r
2.6.1.51 L-serine + phenylpyruvate little activity detected Canis lupus familiaris 3-hydroxypyruvate + L-phenylalanine
-
r
2.6.1.51 L-serine + phenylpyruvate little activity detected Felis catus 3-hydroxypyruvate + L-phenylalanine
-
r
2.6.1.51 L-serine + pyruvate
-
Mus musculus 3-hydroxypyruvate + L-alanine
-
r
2.6.1.51 L-serine + pyruvate
-
Rattus norvegicus 3-hydroxypyruvate + L-alanine
-
r
2.6.1.51 L-serine + pyruvate
-
Canis lupus familiaris 3-hydroxypyruvate + L-alanine
-
r
2.6.1.51 L-serine + pyruvate
-
Felis catus 3-hydroxypyruvate + L-alanine
-
r
2.6.1.51 L-serine + pyruvate gluconeogenesis from serine Mus musculus 3-hydroxypyruvate + L-alanine
-
r
2.6.1.51 L-serine + pyruvate gluconeogenesis from serine Rattus norvegicus 3-hydroxypyruvate + L-alanine
-
r
2.6.1.51 L-serine + pyruvate gluconeogenesis from serine Canis lupus familiaris 3-hydroxypyruvate + L-alanine
-
r
2.6.1.51 L-serine + pyruvate gluconeogenesis from serine Felis catus 3-hydroxypyruvate + L-alanine
-
r
2.6.1.51 L-tyrosine + pyruvate
-
Mus musculus 3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
-
?
2.6.1.51 L-tyrosine + pyruvate
-
Rattus norvegicus 3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
-
?
2.6.1.51 lysine + pyruvate
-
Mus musculus 6-amino-2-oxohexanoate + alanine
-
?
2.6.1.51 additional information highly specific for serine as the amino donor Canis lupus familiaris ?
-
?
2.6.1.51 additional information highly specific for serine as the amino donor Felis catus ?
-
?
2.6.1.51 additional information 2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates Mus musculus ?
-
?
2.6.1.51 additional information 2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates Rattus norvegicus ?
-
?
2.6.1.51 additional information 2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates Canis lupus familiaris ?
-
?
2.6.1.51 additional information 2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates Felis catus ?
-
?
2.6.1.51 valine + pyruvate
-
Mus musculus 3-methyl-2-oxobutanoate + alanine
-
?

Subunits

EC Number Subunits Comment Organism
2.6.1.51 dimer 2 * 36000-40000, SDS-PAGE Mus musculus
2.6.1.51 dimer 2 * 36000-40000, SDS-PAGE Rattus norvegicus
2.6.1.51 dimer 2 * 36000-40000, SDS-PAGE Canis lupus familiaris
2.6.1.51 dimer 2 * 36000-40000, SDS-PAGE Felis catus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.51 8.5 9
-
Mus musculus
2.6.1.51 8.5 9
-
Rattus norvegicus
2.6.1.51 8.5 9
-
Canis lupus familiaris
2.6.1.51 8.5 9
-
Felis catus