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Literature summary extracted from

  • Noguchi, T.; Okuno, E.; Kido, R.
    Identity of isoenzyme 1 of histidine-pyruvate aminotransferase with serine-pyruvate aminotransferase (1976), Biochem. J., 159, 607-613.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.51 histidine competitive inhibitor of serine transamination Rattus norvegicus
2.6.1.51 Isonicotinic acid hydrazide
-
 Rattus norvegicus
2.6.1.51 KCN
-
 Rattus norvegicus
2.6.1.51 Semicarbazide
-
 Rattus norvegicus
2.6.1.51 serine competitive inhibitor of histidine transamination Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.51 cytosol
-
 Rattus norvegicus 5829
-
2.6.1.51 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.51 38000
-
 2 * 38000, SDS-PAGE Rattus norvegicus
2.6.1.51 73000
-
 gel filtration Rattus norvegicus
2.6.1.51 75000
-
 sucrose density gradient centrifugation Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.51 L-serine + pyruvate Rattus norvegicus
-
 3-hydroxypyruvate + L-alanine
-
 r
2.6.1.51 L-serine + pyruvate Rattus norvegicus Donryu
-
 3-hydroxypyruvate + L-alanine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.51 Rattus norvegicus
-
 Donryu strain
-
2.6.1.51 Rattus norvegicus Donryu
-
 Donryu strain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.51 isoenzyme 1 of histidine-pyruvate aminotransferase Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.51 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.51 3.47
-
 serine-pyruvate aminotransferase activity Rattus norvegicus
2.6.1.51 25.7
-
 histidine-pyruvate aminotransferase activity Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.6.1.51 -20°C, 50 mM potassium phosphate buffer, pH 7.5 may be stored for at least 6 weeks without loss of either activity Rattus norvegicus
2.6.1.51 0-5°C, little or none of either activity is lost when the enzyme is stored for 2 weeks Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.51 5-hydroxytryptophan + pyruvate
-
 Rattus norvegicus 3-(5-hydroxyindole)-2-oxopropanoate + alanine
-
 ?
2.6.1.51 asparagine + pyruvate
-
 Rattus norvegicus 2-oxosuccinamate + L-alanine
-
 ?
2.6.1.51 glutamine + phenylpyruvate
-
 Rattus norvegicus 4-carbamoyl-2-oxobutanoate + L-phenylalanine
-
 ?
2.6.1.51 glutamine + pyruvate
-
 Rattus norvegicus 4-carbamoyl-2-oxobutanoate + L-alanine
-
 ?
2.6.1.51 glycine + 3-hydroxypyruvate
-
 Rattus norvegicus L-serine + glyoxylate
-
 r
2.6.1.51 histidine + pyruvate
-
 Rattus norvegicus 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
 ?
2.6.1.51 L-alanine + phenylpyruvate
-
 Rattus norvegicus pyruvate + L-phenylalanine
-
 ?
2.6.1.51 L-asparagine + phenylpyruvate
-
 Rattus norvegicus 2-oxosuccinamate + L-phenylalanine
-
 ?
2.6.1.51 L-leucine + phenylpyruvate
-
 Rattus norvegicus 4-methyl-2-oxopentanoate + L-phenylalanine
-
 ?
2.6.1.51 L-methionine + phenylpyruvate
-
 Rattus norvegicus 4-methylsulfanyl-2-oxobutanoate + L-phenylalanine
-
 ?
2.6.1.51 L-methionine + phenylpyruvate
-
 Rattus norvegicus Donryu 4-methylsulfanyl-2-oxobutanoate + L-phenylalanine
-
 ?
2.6.1.51 L-methionine + pyruvate
-
 Rattus norvegicus 4-methylsulfanyl-2-oxobutanoate + L-alanine
-
 ?
2.6.1.51 L-phenylalanine + pyruvate
-
 Rattus norvegicus phenylpyruvate + L-alanine
-
 ?
2.6.1.51 L-phenylalanine + pyruvate
-
 Rattus norvegicus Donryu phenylpyruvate + L-alanine
-
 ?
2.6.1.51 L-serine + oxaloacetate
-
 Rattus norvegicus 3-hydroxypyruvate + L-aspartate
-
 ?
2.6.1.51 L-serine + pyruvate
-
 Rattus norvegicus 3-hydroxypyruvate + L-alanine
-
 r
2.6.1.51 L-serine + pyruvate
-
 Rattus norvegicus Donryu 3-hydroxypyruvate + L-alanine
-
 r
2.6.1.51 L-tryptophan + pyruvate
-
 Rattus norvegicus 3-indole-2-oxopropanoate + L-alanine
-
 ?
2.6.1.51 L-tyrosine + pyruvate
-
 Rattus norvegicus 3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
-
 ?
2.6.1.51 L-tyrosine + pyruvate
-
 Rattus norvegicus Donryu 3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
-
 ?
2.6.1.51 additional information identical with histidine-pyruvate aminotransferase isoenzyme 1, isoleucine and oxoglutarate are no substrates Rattus norvegicus ?
-
 ?
2.6.1.51 additional information identical with histidine-pyruvate aminotransferase isoenzyme 1, isoleucine and oxoglutarate are no substrates Rattus norvegicus Donryu ?
-
 ?
2.6.1.51 ornithine + phenylpyruvate
-
 Rattus norvegicus 5-amino-2-oxopentanoate + L-phenylalanine
-
 ?
2.6.1.51 ornithine + pyruvate
-
 Rattus norvegicus 5-amino-2-oxopentanoate + L-alanine
-
 ?
2.6.1.51 threonine + phenylpyruvate
-
 Rattus norvegicus 3-hydroxy-2-oxobutanoate + L-phenylalanine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.6.1.51 dimer 2 * 38000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.6.1.51 isoenzyme 1 of histidine-pyruvate aminotransferase
-
 Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.6.1.51 70
-
 heating of the purified enzyme for different lengths of time produces equivalent losses of both activities Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.51 9
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.6.1.51 8 9.5
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.51 pyridoxal 5'-phosphate
-
 Rattus norvegicus