Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tamegai, H.; Eguchi, T.; Kakinuma, K.
    First identification of Streptomyces genes involved in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics: genetic and evolutionary analysis of L-glutamine:2-deoxy-scyllo-inose aminotransferase genes (2002), J. Antibiot., 55, 1016-1018.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.6.1.50 pharmacology biosynthesis of aminoglycoside antibiotics Streptomyces fradiae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.50
-
 Streptomyces fradiae
2.6.1.50 btrS gene identified and heterologously expressed Niallia circulans
2.6.1.50 btrS homologous gene identified and sequenced Streptomyces fradiae
2.6.1.50 btrS homologous gene identified and sequenced Streptoalloteichus hindustanus
2.6.1.50 btrS homologous gene identified and sequenced Streptomyces ribosidificus
2.6.1.100 gene btrS, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression in Escherichia coli strain JM109 Streptomyces fradiae
2.6.1.100 gene btrS, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression in Escherichia coli strain JM109 Streptoalloteichus hindustanus
2.6.1.100 gene btrS, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression in Escherichia coli strain JM109 Streptomyces ribosidificus
2.6.1.100 gene btrS, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression in Escherichia coli strain JM109 Streptomyces kanamyceticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose Streptomyces fradiae
-
 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose Streptoalloteichus hindustanus
-
 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose Streptomyces ribosidificus
-
 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose Streptomyces kanamyceticus
-
 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose Streptomyces ribosidificus JCM 4923
-
 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose Streptomyces kanamyceticus JCM 4433
-
 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose Streptomyces fradiae IFO13147
-
 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose Streptomyces fradiae IFO12773
-
 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.50 Niallia circulans
-
-
-
2.6.1.50 Streptoalloteichus hindustanus Q6F6I1 JCM4433, nucleotide sequence deposited with the same accession number in EMBL/GenBank
-
2.6.1.50 Streptomyces fradiae Q53U20 IFO12773, nucleotide sequence deposited with the same accession number in EMBL/GenBank
-
2.6.1.50 Streptomyces fradiae Q53U20 IFO 13147, nucleotide sequence deposited with the same accession number in EMBL/GenBank
-
2.6.1.50 Streptomyces ribosidificus Q4R0W2 JCM4923, nucleotide sequence deposited with the same accession number in EMBL/GenBank
-
2.6.1.100 no activity in Streptomyces lividans
-
 strain TK24
-
2.6.1.100 Streptoalloteichus hindustanus Q6F6I1 gene btrS or alloG
-
2.6.1.100 Streptomyces fradiae Q53U20 gene btrS, neoB, nemB, neo6, neoS, or nmcS
-
2.6.1.100 Streptomyces fradiae IFO12773 Q53U20 gene btrS, neoB, nemB, neo6, neoS, or nmcS
-
2.6.1.100 Streptomyces fradiae IFO13147 Q53U20 gene btrS, neoB, nemB, neo6, neoS, or nmcS
-
2.6.1.100 Streptomyces kanamyceticus Q6L739 gene btrS
-
2.6.1.100 Streptomyces kanamyceticus JCM 4433 Q6L739 gene btrS
-
2.6.1.100 Streptomyces ribosidificus Q4R0W2 gene btrS, rbmB, rbcS, or ribS; gene btrS
-
2.6.1.100 Streptomyces ribosidificus JCM 4923 Q4R0W2 gene btrS, rbmB, rbcS, or ribS; gene btrS
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose
-
 Streptomyces fradiae 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose
-
 Streptoalloteichus hindustanus 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose
-
 Streptomyces ribosidificus 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose
-
 Streptomyces kanamyceticus 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose
-
 Streptomyces ribosidificus JCM 4923 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose
-
 Streptomyces kanamyceticus JCM 4433 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose
-
 Streptomyces fradiae IFO13147 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?
2.6.1.100 L-glutamine + 2-deoxy-scyllo-inosose
-
 Streptomyces fradiae IFO12773 2-oxoglutaramate + 2-deoxy-scyllo-inosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.50 L-glutamine:2-deoxy-scyllo-inosose
-
 Streptomyces fradiae
2.6.1.100 BtrS
-
 Streptomyces fradiae
2.6.1.100 BtrS
-
 Streptoalloteichus hindustanus
2.6.1.100 BtrS
-
 Streptomyces ribosidificus
2.6.1.100 BtrS
-
 Streptomyces kanamyceticus
2.6.1.100 L-glutamine:DOI aminotransferase
-
 Streptomyces fradiae
2.6.1.100 L-glutamine:DOI aminotransferase
-
 Streptoalloteichus hindustanus
2.6.1.100 L-glutamine:DOI aminotransferase
-
 Streptomyces ribosidificus
2.6.1.100 L-glutamine:DOI aminotransferase
-
 Streptomyces kanamyceticus

General Information

EC Number General Information Comment Organism
2.6.1.100 metabolism the enzyme is involved in the biosynthesis of kanamycin Streptomyces kanamyceticus
2.6.1.100 metabolism the enzyme is involved in the biosynthesis of neomycin Streptomyces fradiae
2.6.1.100 metabolism the enzyme is involved in the biosynthesis of ribostamycin Streptomyces ribosidificus