Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Iwasaki, Y.; Lamar, C.; Danenberg, K.; Pitot, H.C.
    Studies on the induction and repression of enzymes in rat liver. Characterization and metabolic regulation of multiple forms of tyrosine aminotransferase (1973), Eur. J. Biochem., 34, 347-357.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.5 L-glutamate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.5 0.9
-
 2-oxoglutarate pH 7.6, 37°C, enzyme form I Rattus norvegicus
2.6.1.5 1
-
 2-oxoglutarate pH 7.6, 37°C, enzyme form III Rattus norvegicus
2.6.1.5 1.1
-
 2-oxoglutarate pH 7.6, 37°C, enzyme form II Rattus norvegicus
2.6.1.5 1.2
-
 2-oxoglutarate pH 7.6, 37°C, enzyme form IV Rattus norvegicus
2.6.1.5 1.4
-
 L-tyrosine pH 7.6, 37°C, enzyme form II Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.5 107000
-
 gel filtration, different isoenzymes Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.5 Rattus norvegicus
-
 4 enzyme forms from kidney, heart and brain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.5 separation of 4 enzyme forms: I, II, III, IV, using hydroxyapatite chromatography Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.5 heart
-
 Rattus norvegicus
-
2.6.1.5 kidney
-
 Rattus norvegicus
-
2.6.1.5 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.5 additional information
-
 effect of glucagon, cyclic nucletides, insulin and hydrocortisone on activity Rattus norvegicus
2.6.1.5 additional information
-
 activities of different isoenzymes from liver, kidney and heart Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.5 L-phenylalanine + 2-oxoglutarate
-
 Rattus norvegicus phenylpyruvate + L-glutamate
-
 ?
2.6.1.5 L-tyrosine + 2-oxoglutarate
-
 Rattus norvegicus 4-hydroxyphenylpyruvate + L-glutamate
-
 ?
2.6.1.5 tryptophan + 2-oxoglutarate
-
 Rattus norvegicus 3-indole-2-oxopropanoate + L-glutamate
-
 ?

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.6.1.5 additional information
-
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.5 pyridoxamine 5'-phosphate can replace pyridoxal 5'-phosphate Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.5 20.3
-
 L-glutamate pH 7.6, 37°C, isozyme I from kidney, L-tyrosine as substrate Rattus norvegicus
2.6.1.5 26.8
-
 L-glutamate pH 7.6, 37°C, isozyme IV from liver, L-tyrosine as substrate Rattus norvegicus
2.6.1.5 27.4
-
 L-glutamate pH 7.6, 37°C, isozyme III from liver, L-tyrosine as substrate Rattus norvegicus
2.6.1.5 31.3
-
 L-glutamate pH 7.6, 37°C, isozyme II from liver, L-tyrosine as substrate Rattus norvegicus