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Literature summary extracted from

  • Der Garabedian, P.A.; Vermeersch, J.J.
    Lysine degradation in Candida. Characterization and probable role of L-norleucine-leucine, 4-aminobutyrate and delta-aminovalerate:2-oxoglutarate aminotransferases (1989), Biochimie, 71, 497-503.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.6.1.67 L-lysine this enzyme is strongly induced in vivo by growing Candida on L-lysine Candida guilliermondii var. membranaefaciens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.48 5-aminopentanoate + 2-oxoglutarate Meyerozyma guilliermondii catabolism of lysine 5-oxovalerate + L-glutamate
-
r
2.6.1.67 L-leucine + 2-oxoglutarate Candida guilliermondii var. membranaefaciens
-
4-methyl-2-oxopentanoate + L-glutamate
-
?
2.6.1.67 L-norleucine + 2-oxoglutarate Candida guilliermondii var. membranaefaciens
-
2-oxohexanoate + L-glutamate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.48 Meyerozyma guilliermondii
-
var.membranaefaciens
-
2.6.1.67 Candida guilliermondii var. membranaefaciens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.67 ammonium sulfate partial purification and several chromatographic steps, all steps at 4°C Candida guilliermondii var. membranaefaciens

Storage Stability

EC Number Storage Stability Organism
2.6.1.67 -25°C, stable in the presence of 0.01 mM pyridoxal 5'-phosphate and 0.01 mM 2-oxoglutarate Candida guilliermondii var. membranaefaciens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.48 5-aminopentanoate + 2-oxoglutarate
-
Meyerozyma guilliermondii 5-oxovalerate + L-glutamate
-
r
2.6.1.48 5-aminopentanoate + 2-oxoglutarate catabolism of lysine Meyerozyma guilliermondii 5-oxovalerate + L-glutamate
-
r
2.6.1.67 5-N-methylornithine + 2-oxoglutarate
-
Candida guilliermondii var. membranaefaciens 5-(methylamino)-2-oxopentanoic acid + L-glutamate
-
?
2.6.1.67 6-N-acetyllysine + 2-oxoglutarate
-
Candida guilliermondii var. membranaefaciens 6-(acetylamino)-2-oxohexanoic acid + L-glutamate
-
?
2.6.1.67 L-aspartate + 2-oxoglutarate 4.3% of activity compared to L-norleucine Candida guilliermondii var. membranaefaciens oxaloacetate + L-glutamate
-
?
2.6.1.67 L-isoleucine + 2-oxoglutarate
-
Candida guilliermondii var. membranaefaciens 3-methyl-2-oxopentanoate + L-glutamate
-
?
2.6.1.67 L-leucine + 2-oxoglutarate
-
Candida guilliermondii var. membranaefaciens 4-methyl-2-oxopentanoate + L-glutamate
-
?
2.6.1.67 L-norleucine + 2-oxoglutarate
-
Candida guilliermondii var. membranaefaciens 2-oxohexanoate + L-glutamate
-
?
2.6.1.67 L-norvaline + 2-oxoglutarate
-
Candida guilliermondii var. membranaefaciens 2-oxopentanoate + L-glutamate
-
?
2.6.1.67 additional information glycine, L-alanine, L-tyrosine, beta-alanine, epsilon-aminocaproate, delta-aminovalerate, L-arginine, L-lysine or L-ornithine are no substrates Candida guilliermondii var. membranaefaciens ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.48 40
-
-
Meyerozyma guilliermondii
2.6.1.48 40 55 maximal activity at 55, 45 and 40°C Meyerozyma guilliermondii
2.6.1.67 35
-
assay at Candida guilliermondii var. membranaefaciens
2.6.1.67 55
-
-
Candida guilliermondii var. membranaefaciens

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.6.1.67 25 55 reaction velocity increases linearly with increasing temperature at pH 7.8, above 55°C activity rapidly decreases, 2-oxoglutarate and to a lesser extent pyridoxal 5'-phosphate are effective protecting agents toward heating Candida guilliermondii var. membranaefaciens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.6.1.67 55
-
5 min, about 20% activity remaining activity, with addition of pyridoxal 5'-phosphate 80% remaining activity, with addition of 2-oxoglutarate 100% remaining activity Candida guilliermondii var. membranaefaciens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.48 7.8 8.5
-
Meyerozyma guilliermondii