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Literature summary extracted from

  • Noguchi, T.; Okuno, E.; Takada, Y.; Minatogawa, Y.; Okai, K.; Kido, R.
    Characteristics of hepatic alanine-glyoxylate aminotransferase in different mammalian species (1978), Biochem. J., 169, 113-122.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.6.1.44 glucagon induced by, isoenzyme 1 is increased in activity Mus musculus
2.6.1.44 glucagon induced by, isoenzyme 1 is increased in activity Rattus norvegicus
2.6.1.44 glucagon induced by, isoenzyme 1 is increased in activity Canis lupus familiaris
2.6.1.44 glucagon induced by, isoenzyme 1 is increased in activity Felis catus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.44 hydroxylamine isoenzyme 1 Canis lupus familiaris
2.6.1.44 hydroxylamine isoenzyme 1 Felis catus
2.6.1.44 hydroxylamine isoenzyme; isoenzyme 1 Mus musculus
2.6.1.44 hydroxylamine isoenzyme; isoenzyme 1 Rattus norvegicus
2.6.1.44 Isonicotinic acid hydrazide isoenzyme 1 and isoenzyme 2 Mus musculus
2.6.1.44 Isonicotinic acid hydrazide isoenzyme 1 and isoenzyme 2 Rattus norvegicus
2.6.1.44 Semicarbazide isoenzyme 1 Canis lupus familiaris
2.6.1.44 Semicarbazide isoenzyme 1 Felis catus
2.6.1.44 Semicarbazide isoenzyme; isoenzyme 1 Mus musculus
2.6.1.44 Semicarbazide isoenzyme; isoenzyme 1 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.44 0.07
-
glyoxylate pH 8.2, 37°C, isoenzyme 1, alanine as amino donor Rattus norvegicus
2.6.1.44 0.1
-
glyoxylate pH 8.2, 37°C, isoenzyme 1, alanine as amino donor Felis catus
2.6.1.44 0.13
-
glyoxylate pH 8.2, 37°C, isoenzyme 1, alanine as amino donor Canis lupus familiaris
2.6.1.44 0.2
-
glyoxylate pH 8.2, 37°C, isoenzyme 1, alanine as amino donor Mus musculus
2.6.1.44 0.72
-
glyoxylate pH 8.0, 37°C, alanine as amino donor Mus musculus
2.6.1.44 1
-
glyoxylate pH 8.2, 37°C, isoenzyme 2, alanine as amino donor Rattus norvegicus
2.6.1.44 1.4
-
L-alanine pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor Mus musculus
2.6.1.44 2.1
-
L-alanine pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor Rattus norvegicus
2.6.1.44 3
-
L-alanine pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor Canis lupus familiaris
2.6.1.44 3.9
-
L-alanine pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor Canis lupus familiaris
2.6.1.44 25
-
L-alanine pH 8.2, 37°C, isoenzyme 2, glyoxylate as amino acceptor Mus musculus
2.6.1.44 30
-
L-alanine pH 8.2, 37°C, isoenzyme 2, glyoxylate as amino acceptor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.44 mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.44 38000
-
2 * 38000, isoenzyme 1, SDS-PAGE Mus musculus
2.6.1.44 38000
-
2 * 38000, isoenzyme 1, SDS-PAGE Rattus norvegicus
2.6.1.44 38000
-
2 * 38000, isoenzyme 1, SDS-PAGE Canis lupus familiaris
2.6.1.44 38000
-
2 * 38000, isoenzyme 1, SDS-PAGE Felis catus
2.6.1.44 77000
-
-
Mus musculus
2.6.1.44 77000
-
-
Canis lupus familiaris
2.6.1.44 77000
-
-
Felis catus
2.6.1.44 77000
-
isoenzyme 1, gel filtration Rattus norvegicus
2.6.1.44 80000
-
sucrose-density-gradient centrifugation Mus musculus
2.6.1.44 80000
-
sucrose-density-gradient centrifugation Rattus norvegicus
2.6.1.44 80000
-
sucrose-density-gradient centrifugation Canis lupus familiaris
2.6.1.44 80000
-
sucrose-density-gradient centrifugation Felis catus
2.6.1.44 80000
-
peroxisomal and mitochondrial alanine-glyoxylate aminotransferase 1 Rattus norvegicus
2.6.1.44 170000
-
isoenzyme 2, gel filtration Rattus norvegicus
2.6.1.44 175000
-
-
Canis lupus familiaris
2.6.1.44 175000
-
liver isoenzyme 2, gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.44 L-alanine + glyoxylate Mus musculus
-
pyruvate + glycine
-
ir
2.6.1.44 L-alanine + glyoxylate Rattus norvegicus
-
pyruvate + glycine
-
ir
2.6.1.44 L-alanine + glyoxylate Canis lupus familiaris
-
pyruvate + glycine
-
ir
2.6.1.44 L-alanine + glyoxylate Felis catus
-
pyruvate + glycine
-
ir

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.44 Canis lupus familiaris
-
dog
-
2.6.1.44 Felis catus
-
cat
-
2.6.1.44 Mus musculus
-
mouse
-
2.6.1.44 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.44 isoenzyme 1 Canis lupus familiaris
2.6.1.44 isoenzyme 1 Felis catus
2.6.1.44 isoenzyme 1 and 2 Mus musculus
2.6.1.44 isoenzyme 1 and 2 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.44 liver
-
Mus musculus
-
2.6.1.44 liver
-
Rattus norvegicus
-
2.6.1.44 liver
-
Canis lupus familiaris
-
2.6.1.44 liver
-
Felis catus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.44 2.64
-
isoenzyme 2 Canis lupus familiaris
2.6.1.44 2.93
-
-
Rattus norvegicus
2.6.1.44 2.93
-
isoenzyme 2 Canis lupus familiaris
2.6.1.44 21.4
-
isoenzyme 1 Rattus norvegicus
2.6.1.44 23.2
-
isoenzyme 1 Mus musculus
2.6.1.44 86.3
-
isoenzyme 1 Felis catus
2.6.1.44 91
-
isoenzyme 1 Canis lupus familiaris
2.6.1.44 160
-
isoenzyme 1 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.6.1.44 -20°C, 50 mM potassium phosphate buffer, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity Rattus norvegicus
2.6.1.44 -20°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity Mus musculus
2.6.1.44 -20°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity Canis lupus familiaris
2.6.1.44 -20°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity Felis catus
2.6.1.44 0-6°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity Mus musculus
2.6.1.44 0-6°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity Rattus norvegicus
2.6.1.44 0-6°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity Canis lupus familiaris
2.6.1.44 0-6°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity Felis catus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.44 L-alanine + glyoxylate
-
Mus musculus pyruvate + glycine
-
ir
2.6.1.44 L-alanine + glyoxylate
-
Rattus norvegicus pyruvate + glycine
-
ir
2.6.1.44 L-alanine + glyoxylate
-
Canis lupus familiaris pyruvate + glycine
-
ir
2.6.1.44 L-alanine + glyoxylate
-
Felis catus pyruvate + glycine
-
ir
2.6.1.44 L-alanine + glyoxylate isoenzyme 1 Mus musculus pyruvate + glycine
-
ir
2.6.1.44 L-alanine + glyoxylate isoenzyme 1 Rattus norvegicus pyruvate + glycine
-
ir
2.6.1.44 L-alanine + glyoxylate isoenzyme 2 highly specific, little or no activity with other amino donors/acceptors Mus musculus pyruvate + glycine
-
ir
2.6.1.44 L-alanine + glyoxylate isoenzyme 2 highly specific, little or no activity with other amino donors/acceptors Rattus norvegicus pyruvate + glycine
-
ir
2.6.1.44 L-alanine + hydroxypyruvate
-
Canis lupus familiaris pyruvate + L-serine
-
ir
2.6.1.44 L-alanine + hydroxypyruvate
-
Felis catus pyruvate + L-serine
-
ir
2.6.1.44 L-alanine + hydroxypyruvate isoenzyme 1 Mus musculus pyruvate + L-serine
-
ir
2.6.1.44 L-alanine + hydroxypyruvate isoenzyme 1 Rattus norvegicus pyruvate + L-serine
-
ir
2.6.1.44 L-alanine + phenylpyruvate isoenzyme 1 Mus musculus pyruvate + L-phenylalanine
-
ir
2.6.1.44 L-alanine + phenylpyruvate isoenzyme 1 Rattus norvegicus pyruvate + L-phenylalanine
-
ir
2.6.1.44 L-alanine + phenylpyruvate isoenzyme 1, less effectively acceptor Canis lupus familiaris pyruvate + L-phenylalanine
-
ir
2.6.1.44 L-alanine + phenylpyruvate isoenzyme 1, less effectively acceptor Felis catus pyruvate + L-phenylalanine
-
ir
2.6.1.44 L-asparagine + glyoxylate isoenzyme 1 Mus musculus 4-amino-2,4-dioxobutanoate + glycine
-
ir
2.6.1.44 L-asparagine + glyoxylate isoenzyme 1 Rattus norvegicus 4-amino-2,4-dioxobutanoate + glycine
-
ir
2.6.1.44 L-glutamine + glyoxylate isoenzyme 1 Mus musculus 2-oxoglutaramate + glycine
-
ir
2.6.1.44 L-glutamine + glyoxylate isoenzyme 1 Rattus norvegicus 2-oxoglutaramate + glycine
-
ir
2.6.1.44 L-histidine + glyoxylate isoenzyme 1 Mus musculus 3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
ir
2.6.1.44 L-histidine + glyoxylate isoenzyme 1 Rattus norvegicus 3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
ir
2.6.1.44 L-isoleucine + glyoxylate isoenzyme 1 Mus musculus 3-methyl-2-oxopropanoate + glycine
-
ir
2.6.1.44 L-leucine + glyoxylate isoenzyme 1 Mus musculus 4-methyl-2-oxopentanoate + glycine
-
ir
2.6.1.44 L-leucine + glyoxylate isoenzyme 1 Rattus norvegicus 4-methyl-2-oxopentanoate + glycine
-
ir
2.6.1.44 L-methionine + glyoxylate isoenzyme 1 Mus musculus 4-methylsulfanyl-2-oxobutanoate + glycine
-
ir
2.6.1.44 L-methionine + glyoxylate isoenzyme 1 Rattus norvegicus 4-methylsulfanyl-2-oxobutanoate + glycine
-
ir
2.6.1.44 L-phenylalanine + glyoxylate isoenzyme 1 Mus musculus phenylpyruvate + glycine
-
ir
2.6.1.44 L-phenylalanine + glyoxylate isoenzyme 1 Rattus norvegicus phenylpyruvate + glycine
-
ir
2.6.1.44 L-serine + glyoxylate
-
Canis lupus familiaris 3-hydroxy-2-oxopropanoate + glycine
-
ir
2.6.1.44 L-serine + glyoxylate
-
Felis catus 3-hydroxy-2-oxopropanoate + glycine
-
ir
2.6.1.44 L-serine + glyoxylate isoenzyme 1 Mus musculus 3-hydroxy-2-oxopropanoate + glycine
-
ir
2.6.1.44 L-serine + glyoxylate isoenzyme 1 Rattus norvegicus 3-hydroxy-2-oxopropanoate + glycine
-
ir
2.6.1.44 L-serine + pyruvate isoenzyme 1 Mus musculus 3-hydroxy-2-oxopropanoate + L-alanine
-
ir
2.6.1.44 L-serine + pyruvate isoenzyme 1 Rattus norvegicus 3-hydroxy-2-oxopropanoate + L-alanine
-
ir
2.6.1.44 L-serine + pyruvate isoenzyme 1 Canis lupus familiaris 3-hydroxy-2-oxopropanoate + L-alanine
-
ir
2.6.1.44 L-serine + pyruvate isoenzyme 1 Felis catus 3-hydroxy-2-oxopropanoate + L-alanine
-
ir
2.6.1.44 L-tyrosine + glyoxylate isoenzyme 1 Mus musculus 3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
ir
2.6.1.44 L-tyrosine + glyoxylate isoenzyme 1 Rattus norvegicus 3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
ir
2.6.1.44 L-valine + glyoxylate isoenzyme 1 Mus musculus 3-methyl-2-oxobutanoate + glycine
-
ir
2.6.1.44 additional information isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan Mus musculus ?
-
?
2.6.1.44 additional information isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan Rattus norvegicus ?
-
?
2.6.1.44 additional information isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan Canis lupus familiaris ?
-
?
2.6.1.44 additional information isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan Felis catus ?
-
?

Subunits

EC Number Subunits Comment Organism
2.6.1.44 dimer 2 * 38000, isoenzyme 1, SDS-PAGE Mus musculus
2.6.1.44 dimer 2 * 38000, isoenzyme 1, SDS-PAGE Rattus norvegicus
2.6.1.44 dimer 2 * 38000, isoenzyme 1, SDS-PAGE Canis lupus familiaris
2.6.1.44 dimer 2 * 38000, isoenzyme 1, SDS-PAGE Felis catus

Synonyms

EC Number Synonyms Comment Organism
2.6.1.44 EC 2.6.1.51 serine-pyruvate aminotransferase identical with liver isoenzyme 1 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.44 8.1 8.4 isoenzyme 2 Mus musculus
2.6.1.44 8.3 8.6
-
Mus musculus
2.6.1.44 8.3 8.6
-
Rattus norvegicus
2.6.1.44 8.3 8.6
-
Canis lupus familiaris
2.6.1.44 8.3 8.6
-
Felis catus
2.6.1.44 8.5 8.8 isoenzyme 2 Rattus norvegicus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.6.1.44 Mus musculus isoelectric focusing on a pH 3.5-10 ampholine gradient
-
5.9
2.6.1.44 Rattus norvegicus isoelectric focusing on a pH 3.5-10 ampholine gradient
-
6