BRENDA - Enzyme Database show

Evidence of hemin as an end product inhibitor of L-alanine: 4,5-dioxovalerate transaminase in rat liver mitochondria

Shanker, J.; Datta, K.; FEBS Lett. 189, 129-132 (1985)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.43
hemin
-
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.6.1.43
mitochondrion
-
Rattus norvegicus
5739
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.6.1.43
L-alanine + 4,5-dioxopentanoate
Rattus norvegicus
heme biosynthetic pathway
5-aminolevulinate + pyruvate
-
Rattus norvegicus
ir
2.6.1.43
L-alanine + 4,5-dioxopentanoate
Rattus norvegicus Wistar
heme biosynthetic pathway
5-aminolevulinate + pyruvate
-
Rattus norvegicus Wistar
ir
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.6.1.43
Rattus norvegicus
-
Wistar
-
2.6.1.43
Rattus norvegicus Wistar
-
Wistar
-
Purification (Commentary)
EC Number
Commentary
Organism
2.6.1.43
-
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.6.1.43
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.43
L-alanine + 4,5-dioxopentanoate
-
640051
Rattus norvegicus
5-aminolevulinate + pyruvate
-
640051
Rattus norvegicus
ir
2.6.1.43
L-alanine + 4,5-dioxopentanoate
heme biosynthetic pathway
640051
Rattus norvegicus
5-aminolevulinate + pyruvate
-
640051
Rattus norvegicus
ir
2.6.1.43
L-alanine + 4,5-dioxopentanoate
-
640051
Rattus norvegicus Wistar
5-aminolevulinate + pyruvate
-
640051
Rattus norvegicus Wistar
ir
2.6.1.43
L-alanine + 4,5-dioxopentanoate
heme biosynthetic pathway
640051
Rattus norvegicus Wistar
5-aminolevulinate + pyruvate
-
640051
Rattus norvegicus Wistar
ir
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.6.1.43
30
-
hemin
different concentrations of alanine at fixed 4,5-dioxopentanoate concentration
Rattus norvegicus
2.6.1.43
42
-
hemin
different concentrations of 4,5-dioxopentanoate concentration at fixed alanine concentration
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.43
hemin
-
Rattus norvegicus
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.6.1.43
30
-
hemin
different concentrations of alanine at fixed 4,5-dioxopentanoate concentration
Rattus norvegicus
2.6.1.43
42
-
hemin
different concentrations of 4,5-dioxopentanoate concentration at fixed alanine concentration
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.6.1.43
mitochondrion
-
Rattus norvegicus
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.6.1.43
L-alanine + 4,5-dioxopentanoate
Rattus norvegicus
heme biosynthetic pathway
5-aminolevulinate + pyruvate
-
Rattus norvegicus
ir
2.6.1.43
L-alanine + 4,5-dioxopentanoate
Rattus norvegicus Wistar
heme biosynthetic pathway
5-aminolevulinate + pyruvate
-
Rattus norvegicus Wistar
ir
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.6.1.43
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.6.1.43
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.43
L-alanine + 4,5-dioxopentanoate
-
640051
Rattus norvegicus
5-aminolevulinate + pyruvate
-
640051
Rattus norvegicus
ir
2.6.1.43
L-alanine + 4,5-dioxopentanoate
heme biosynthetic pathway
640051
Rattus norvegicus
5-aminolevulinate + pyruvate
-
640051
Rattus norvegicus
ir
2.6.1.43
L-alanine + 4,5-dioxopentanoate
-
640051
Rattus norvegicus Wistar
5-aminolevulinate + pyruvate
-
640051
Rattus norvegicus Wistar
ir
2.6.1.43
L-alanine + 4,5-dioxopentanoate
heme biosynthetic pathway
640051
Rattus norvegicus Wistar
5-aminolevulinate + pyruvate
-
640051
Rattus norvegicus Wistar
ir