EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.42 | 2-mercaptoethanol | - |
Rattus norvegicus | |
2.6.1.42 | 2-mercaptoethanol | - |
Sus scrofa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.6 | 2-mercaptoethanol | slight inhibition | Rattus norvegicus | |
2.6.1.6 | p-chloromercuribenzoate | 1.0 mM, complete inhibition | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.6 | 0.065 | - |
2-oxoglutarate | pH 8.2, 37°C | Rattus norvegicus | |
2.6.1.6 | 25 | - |
leucine | pH 8.2, 37°C | Rattus norvegicus | |
2.6.1.42 | 0.75 | - |
L-leucine | pH 8.2, 37°C | Rattus norvegicus | |
2.6.1.42 | 0.84 | - |
L-isoleucine | pH 8.2, 37°C | Rattus norvegicus | |
2.6.1.42 | 1 | - |
2-oxoglutarate | pH 8.2, 37°C | Rattus norvegicus | |
2.6.1.42 | 4.3 | - |
L-valine | pH 8.2, 37°C | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.6.1.6 | cytoplasm | predominantly found in mitochondrion | Rattus norvegicus | 5737 | - |
2.6.1.6 | microsome | - |
Rattus norvegicus | - |
- |
2.6.1.6 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
2.6.1.6 | nucleus | - |
Rattus norvegicus | 5634 | - |
2.6.1.42 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
2.6.1.42 | cytoplasm | - |
Sus scrofa | 5737 | - |
2.6.1.42 | microsome | - |
Rattus norvegicus | - |
- |
2.6.1.42 | mitochondrion | - |
Sus scrofa | 5739 | - |
2.6.1.42 | mitochondrion | mainly located in the cytoplasm | Rattus norvegicus | 5739 | - |
2.6.1.42 | nucleus | - |
Rattus norvegicus | 5634 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.6 | L-leucine + 2-oxoglutarate | Rattus norvegicus | leucine metabolism and hence of cholesterogenesis and ketogenesis, not present in fetal rat liver, but after birth activity appears and increases rapidly | 4-methyl-2-oxopentanoate + L-glutamate | - |
? | |
2.6.1.42 | L-isoleucine + 2-oxoglutarate | Rattus norvegicus | - |
3-methyl-2-oxopentanoate + L-glutamate | - |
r | |
2.6.1.42 | L-isoleucine + 2-oxoglutarate | Sus scrofa | - |
3-methyl-2-oxopentanoate + L-glutamate | - |
r | |
2.6.1.42 | L-leucine + 2-oxoglutarate | Sus scrofa | - |
4-methyl-2-oxopentanoate + L-glutamate | - |
r | |
2.6.1.42 | L-leucine + 2-oxoglutarate | Rattus norvegicus | sole transaminase in fetal rat liver | 4-methyl-2-oxopentanoate + L-glutamate | - |
r | |
2.6.1.42 | L-valine + 2-oxoglutarate | Rattus norvegicus | - |
3-methyl-2-oxobutanoate + L-glutamate | - |
r | |
2.6.1.42 | L-valine + 2-oxoglutarate | Sus scrofa | - |
3-methyl-2-oxobutanoate + L-glutamate | - |
r | |
2.6.1.42 | additional information | Rattus norvegicus | specific for L-leucine, L-isoleucine or L-valine, no other amino acid would serve as an amino donor | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.6 | Rattus norvegicus | - |
- |
- |
2.6.1.42 | Rattus norvegicus | - |
rat, strain Wistar | - |
2.6.1.42 | Sus scrofa | - |
pig, hog | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.6.1.6 | - |
Rattus norvegicus |
2.6.1.42 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.6.1.6 | liver | - |
Rattus norvegicus | - |
2.6.1.42 | liver | - |
Rattus norvegicus | - |
2.6.1.42 | liver | - |
Sus scrofa | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.6.1.6 | 1.033 | - |
- |
Rattus norvegicus |
2.6.1.42 | 0.01855 | - |
- |
Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.6 | L-leucine + 2-oxoglutarate | - |
Rattus norvegicus | 4-methyl-2-oxopentanoate + L-glutamate | - |
r | |
2.6.1.6 | L-leucine + 2-oxoglutarate | leucine metabolism and hence of cholesterogenesis and ketogenesis, not present in fetal rat liver, but after birth activity appears and increases rapidly | Rattus norvegicus | 4-methyl-2-oxopentanoate + L-glutamate | - |
? | |
2.6.1.6 | L-leucine + oxaloacetate | - |
Rattus norvegicus | 4-methyl-2-oxopentanoate + L-aspartate | - |
? | |
2.6.1.6 | additional information | specific for leucine, isoleucine or valine, no other amino acid would serve as an amino donor, pyruvate is no amino acid acceptor | Rattus norvegicus | ? | - |
? | |
2.6.1.42 | L-isoleucine + 2-oxoglutarate | - |
Rattus norvegicus | 3-methyl-2-oxopentanoate + L-glutamate | - |
r | |
2.6.1.42 | L-isoleucine + 2-oxoglutarate | - |
Sus scrofa | 3-methyl-2-oxopentanoate + L-glutamate | - |
r | |
2.6.1.42 | L-leucine + 2-oxoglutarate | - |
Rattus norvegicus | 4-methyl-2-oxopentanoate + L-glutamate | - |
r | |
2.6.1.42 | L-leucine + 2-oxoglutarate | - |
Sus scrofa | 4-methyl-2-oxopentanoate + L-glutamate | - |
r | |
2.6.1.42 | L-leucine + 2-oxoglutarate | sole transaminase in fetal rat liver | Rattus norvegicus | 4-methyl-2-oxopentanoate + L-glutamate | - |
r | |
2.6.1.42 | L-valine + 2-oxoglutarate | - |
Rattus norvegicus | 3-methyl-2-oxobutanoate + L-glutamate | - |
r | |
2.6.1.42 | L-valine + 2-oxoglutarate | - |
Sus scrofa | 3-methyl-2-oxobutanoate + L-glutamate | - |
r | |
2.6.1.42 | additional information | specific for L-leucine, L-isoleucine or L-valine, no other amino acid would serve as an amino donor | Rattus norvegicus | ? | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.6 | 8.7 | - |
- |
Rattus norvegicus |
2.6.1.42 | 8.2 | - |
- |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.6 | pyridoxal 5'-phosphate | Km 0.004 mM | Rattus norvegicus | |
2.6.1.42 | pyridoxal 5'-phosphate | Km 0.025 mM | Rattus norvegicus | |
2.6.1.42 | pyridoxal 5'-phosphate | Km 0.0065 mM | Sus scrofa |