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Literature summary extracted from

  • Milewski, S.; Chmara, H.; Andruszkiewicz, R.; Borowski, E.
    N3-haloacetyl derivatives of L-2,3-diaminopropanoic acid: novel inactivators of glucosamine-6-phosphate synthase (1992), Biochim. Biophys. Acta, 1115, 225-229.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.16 L-2,3-diaminopropanoic acid
-
 Bacillus pumilus
2.6.1.16 L-2,3-diaminopropanoic acid
-
 Candida albicans
2.6.1.16 L-2,3-diaminopropanoic acid
-
 Escherichia coli
2.6.1.16 N3-bromoacetyl-L-2,3-diaminopropanoic acid competitive with respect to L-glutamine Bacillus pumilus
2.6.1.16 N3-bromoacetyl-L-2,3-diaminopropanoic acid competitive with respect to L-glutamine Candida albicans
2.6.1.16 N3-bromoacetyl-L-2,3-diaminopropanoic acid competitive with respect to L-glutamine Escherichia coli
2.6.1.16 N3-chloroacetyl-L-2,3-diaminopropanoic acid competitive with respect to L-glutamine Bacillus pumilus
2.6.1.16 N3-chloroacetyl-L-2,3-diaminopropanoic acid competitive with respect to L-glutamine Candida albicans
2.6.1.16 N3-chloroacetyl-L-2,3-diaminopropanoic acid competitive with respect to L-glutamine Escherichia coli
2.6.1.16 N3-iodoacetyl-L-2,3-diaminopropanoic acid competitive with respect to L-glutamine Bacillus pumilus
2.6.1.16 N3-iodoacetyl-L-2,3-diaminopropanoic acid competitive with respect to L-glutamine Candida albicans
2.6.1.16 N3-iodoacetyl-L-2,3-diaminopropanoic acid competitive with respect to L-glutamine Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.16 Bacillus pumilus
-
-
-
2.6.1.16 Candida albicans
-
-
-
2.6.1.16 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.16 L-glutamine + D-fructose 6-phosphate
-
 Escherichia coli L-glutamate + D-glucosamine 6-phosphate
-
 ?
2.6.1.16 L-glutamine + D-fructose 6-phosphate
-
 Candida albicans L-glutamate + D-glucosamine 6-phosphate
-
 ?
2.6.1.16 L-glutamine + D-fructose 6-phosphate
-
 Bacillus pumilus L-glutamate + D-glucosamine 6-phosphate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.16 0.0001
-
 N3-bromoacetyl-L-2,3-diaminopropanoic acid pH 6.5, 25°C Candida albicans
2.6.1.16 0.000125
-
 N3-iodoacetyl-L-2,3-diaminopropanoic acid pH 6.5, 25°C Candida albicans
2.6.1.16 0.0006
-
 N3-chloroacetyl-L-2,3-diaminopropanoic acid pH 6.5, 25°C Candida albicans