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Literature summary extracted from

  • Mudd, S.H.
    Enzymatic cleavage of S-adenosylmethionine (1959), J. Biol. Chem., 234, 87-92.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.4 5'-O-Methyladenosine weak inhibition Saccharomyces cerevisiae
2.5.1.4 adenine weak inhibition Saccharomyces cerevisiae
2.5.1.4 adenosine weak inhibition Saccharomyces cerevisiae
2.5.1.4 Allo-S-Adenosyl-L-methionine 4 mM inhibits more than 50% Saccharomyces cerevisiae
2.5.1.4 dimethyladenosylsulfonium weak inhibition Saccharomyces cerevisiae
2.5.1.4 ethylthioadenosine 4 mM inhibits more than 50% Saccharomyces cerevisiae
2.5.1.4 L-methionine weak inhibition Saccharomyces cerevisiae
2.5.1.4 methionine methylsulfonium weak inhibition Saccharomyces cerevisiae
2.5.1.4 methylthioadenosine 4 mM inhibits more than 50% Saccharomyces cerevisiae
2.5.1.4 Methylthioinosine weak inhibition Saccharomyces cerevisiae
2.5.1.4 S-adenosyl-L-ethionine 4 mM inhibits more than 50% Saccharomyces cerevisiae
2.5.1.4 S-adenosyl-L-homocysteine 4 mM inhibits 25-50% Saccharomyces cerevisiae
2.5.1.4 S-Ribosylmethionine weak inhibition Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.4 S-adenosyl-L-methionine Saccharomyces cerevisiae
-
 5'-methylthioadenosine + alpha-amino-gamma-butyrolactone
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.4 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.4 partial purification by a method that includes precipitation with acetone, differential heat inactivation and precipitation by ammonium sulfate Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.4 S-adenosyl-L-methionine
-
 Saccharomyces cerevisiae 5'-methylthioadenosine + 2-aminobutan-4-olide
-
 ir
2.5.1.4 S-adenosyl-L-methionine
-
 Saccharomyces cerevisiae 5'-methylthioadenosine + alpha-amino-gamma-butyrolactone
-
 ir
2.5.1.4 S-adenosylethionine
-
 Saccharomyces cerevisiae ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.4 additional information no cofactor is required Saccharomyces cerevisiae