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Literature summary extracted from

  • Camiener, G.W.; Brown, G.M.
    The biosynthesis of thiamine. 2. Fractionation of enzyme system and identification of thiazole monophosphate and thiamine monophosphate as intermediates (1960), J. Biol. Chem., 235, 2411-2417.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.3 Mg2+ required Saccharomyces cerevisiae
2.7.1.50 Mg2+ required Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.3 2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate Saccharomyces cerevisiae involved in biosynthesis of thiamine diphosphate + ?
-
 ?
2.7.1.50 ATP + 4-methyl-5-(2-hydroxyethyl)thiazole Saccharomyces cerevisiae enzyme involved in biosynthesis of thiamine ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.3 Saccharomyces cerevisiae
-
-
-
2.7.1.50 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.3 2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate involved in biosynthesis of thiamine Saccharomyces cerevisiae diphosphate + ?
-
 ?
2.5.1.3 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
-
 Saccharomyces cerevisiae thiamine monophosphate + diphosphate
-
 ?
2.7.1.50 ATP + 4-methyl-5-(2-hydroxyethyl)thiazole
-
 Saccharomyces cerevisiae ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
-
 ?
2.7.1.50 ATP + 4-methyl-5-(2-hydroxyethyl)thiazole enzyme involved in biosynthesis of thiamine Saccharomyces cerevisiae ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
-
 ?