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Literature summary extracted from

  • Williams, D.L.; Spring, L.; Harris, E.; Roche, P.; Gillis, T.P.
    Dihydropteroate synthase of Mycobacterium leprae and dapsone resistance (2000), Antimicrob. Agents Chemother., 44, 1530-1537.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.15 expression in Escherichia coli C600 and in Escherichia coli folP knockout mutant Mycobacterium leprae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.15 dapsone
-
 Mycobacterium leprae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.15 additional information
-
 additional information activity in Escherichia coli C600 and recombinant strains Mycobacterium leprae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Mycobacterium leprae
-
 diphosphate + 7,8-dihydropteroate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Mycobacterium leprae P0C0X1
-
-
2.5.1.15 Mycobacterium leprae P0C0X2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
 Mycobacterium leprae diphosphate + 7,8-dihydropteroate
-
 ?