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Literature summary extracted from

  • Walter, R.D.; Königk, E.
    Biosynthesis of folic acid compounds in plasmodia. Purification and properties of the 7,8-dihydropteroate-synthesizing enzyme from Plasmodium chabaudi (1974), Hoppe-Seyler's Z. Physiol. Chem., 355, 431-437.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-dihydropteridine
-
Plasmodium chabaudi
2.5.1.15 p-Aminobenzoate
-
Plasmodium chabaudi
2.5.1.15 p-Aminosalicylic acid
-
Plasmodium chabaudi
2.5.1.15 Sulfaguanidine
-
Plasmodium chabaudi
2.5.1.15 sulfanilamide
-
Plasmodium chabaudi
2.5.1.15 Sulfanilic acid
-
Plasmodium chabaudi
2.5.1.15 sulfathiazole competitive to 4-aminobenzoate Plasmodium chabaudi
2.5.1.15 sulfonamide competitive to 4-aminobenzoate Plasmodium chabaudi
2.7.6.3 2-Amino-4-hydroxy-6-carboxydihydropteridine competitive with 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine Plasmodium chabaudi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.15 0.0015
-
4-Aminobenzoate
-
Plasmodium chabaudi
2.7.6.3 0.01
-
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pH 8.5, 37°C Plasmodium chabaudi
2.7.6.3 0.011
-
ATP pH 8.5, 37°C Plasmodium chabaudi

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.15 Mg2+ required to synthesize product Plasmodium chabaudi

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.15 190000
-
Sephadex chromatography Plasmodium chabaudi
2.7.6.3 190000
-
gel filtration Plasmodium chabaudi

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Plasmodium chabaudi
-
-
-
2.7.6.3 Plasmodium chabaudi
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.15 precipitation with ammonium sulfate followed by column chromatography Plasmodium chabaudi
2.7.6.3 partial Plasmodium chabaudi

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.15 erythrocyte
-
Plasmodium chabaudi
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.15 15.78
-
-
Plasmodium chabaudi
2.7.6.3 additional information
-
-
Plasmodium chabaudi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Plasmodium chabaudi diphosphate + 7,8-dihydropteroate
-
?
2.7.6.3 ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
-
Plasmodium chabaudi AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.6.3 7,8-dihydropteroate-synthesizing enzyme it is not possible to distinguish, whether the enzyme exists as an enzyme complex of 6-hydroxymethyl-7,8-dihydroxypterin pyrophosphokinase and 7,8-dihydropteroate synthase or whether both reactions are catalyzed by a single enzyme Plasmodium chabaudi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.15 8.7
-
-
Plasmodium chabaudi
2.7.6.3 8.7
-
-
Plasmodium chabaudi

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.15 0.023
-
p-Aminosalicylic acid
-
Plasmodium chabaudi
2.5.1.15 0.043
-
2-amino-4-hydroxy-6-hydroxymethyl-dihydropteridine
-
Plasmodium chabaudi
2.5.1.15 0.069
-
Sulfaguanidine
-
Plasmodium chabaudi
2.5.1.15 0.13
-
sulfanilamide
-
Plasmodium chabaudi
2.5.1.15 0.14
-
Sulfanilic acid
-
Plasmodium chabaudi
2.7.6.3 0.043
-
2-Amino-4-hydroxy-6-carboxydihydropteridine pH 8.5, 37°C Plasmodium chabaudi