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Literature summary extracted from

  • Yohe, H.C.; Yu, R.K.
    In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a (1980), J. Biol. Chem., 255, 608-613.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.3.8 histone slight activation Gallus gallus
2.4.3.8 Triton CF-54 can be replaced by Triton X-100, Tween 80 or Tween 20 with 25%, 11% or 9% efficiency, respectively Gallus gallus
2.4.3.8 Triton X-100
-
 Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.3.8 Ca2+
-
 Gallus gallus
2.4.3.8 EDTA not Gallus gallus
2.4.3.8 additional information no inhibition by Mg2+, CMP-N-acetylneuraminate Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.3.8 1
-
 trisialoganglioside GT1a
-
 Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.8 membrane
-
 Gallus gallus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.8 Gallus gallus
-
 9 days old embryonic brains
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.8 brain
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.8 CMP + trisialoganglioside GT1a
-
 Gallus gallus CMP-N-acetylneuraminate + disialoganglioside GD1a
-
 ?
2.4.3.8 CMP-N-acetylneuraminate + disialoganglioside GD1a
-
 Gallus gallus CMP + trisialoganglioside GT1a
-
 ?
2.4.3.8 CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Gallus gallus CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide i.e. disialosyllactosylceramide or ganglioside GD3 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.3.8 37
-
 assay at Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.3.8 6 7.2 trisialoganglioside formation Gallus gallus