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Literature summary extracted from

  • Grunewald, G.L.; Dahanukar, V.H.; Ching, P.; Criscione, K.R.
    Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase (1996), J. Med. Chem., 39, 3539-3546.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.28 (R)-3-methyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 (S)-3-methyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 2,3,4,5-tetrahydro-1H-2-benzazepine
-
 Bos taurus
2.1.1.28 2,3,4,5-tetrahydro-5H-1,4-benzodiazepine
-
 Bos taurus
2.1.1.28 2,3,4,5-tetrahydro-5H-1,4-benzothiazepine
-
 Bos taurus
2.1.1.28 2,3,4,5-tetrahydro-5H-1,4-benzoxazepine
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.28 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.28 adrenal gland
-
 Bos taurus
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.28 0.00101
-
 (S)-3-methyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.00334
-
 2,3,4,5-tetrahydro-1H-2-benzazepine
-
 Bos taurus
2.1.1.28 0.0041
-
 2,3,4,5-tetrahydro-5H-1,4-benzothiazepine
-
 Bos taurus
2.1.1.28 0.0212
-
 2,3,4,5-tetrahydro-5H-1,4-benzoxazepine
-
 Bos taurus
2.1.1.28 0.028
-
 2,3,4,5-tetrahydro-5H-1,4-benzodiazepine
-
 Bos taurus
2.1.1.28 0.0383
-
 (R)-3-methyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus