Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fuller, R.W.
    Norepinephrine N-methyltransferase from rabbit adrenal glands (1987), Methods Enzymol., 142, 655-660.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.28 2-chlorophenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 2-fluorophenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 3,4-Dichlorophenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 3,4-dihydroxyphenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 3-bromophenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 4-bromophenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 4-fluorophenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 4-hydroxyphenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 epinephrine
-
 Oryctolagus cuniculus
2.1.1.28 S-adenosylhomocysteine
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.28 0.0008
-
 3,4-Dichlorophenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 0.0024
-
 3-chloro-4-hydroxyphenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 0.013
-
 3,4-dihydroxyphenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 0.017
-
 4-hydroxyphenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 0.077
-
 phenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 0.089
-
 3-hydroxyphenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 0.366
-
 3-methoxy-4-hydroxy-phenylethanolamine
-
 Oryctolagus cuniculus
2.1.1.28 0.676
-
 2-hydroxyphenylethanolamine
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.28 additional information Oryctolagus cuniculus terminal enzyme in the biosynthetic pathway for epinephrine ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.28 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.28
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.28 adrenal gland
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.28 2-hydroxyphenylethanolamine + S-adenosyl-L-methionine i.e. o-octopamine Oryctolagus cuniculus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 3,4-dichlorophenyl ethanolamine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 3,4-dichlorophenylethanolamine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus N-methyl-3,4-dichlorophenylethanolamine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 3-chloro-4-hydroxyphenylethanolamine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 3-hydroxyphenylethanolamine + S-adenosyl-L-methionine i.e. m-octopamine Oryctolagus cuniculus N-methyl-m-octopamine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 4-hydroxyphenylethanolamine + S-adenosyl-L-methionine i.e. octopamine Oryctolagus cuniculus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 additional information terminal enzyme in the biosynthetic pathway for epinephrine Oryctolagus cuniculus ?
-
 ?
2.1.1.28 norepinephrine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus epinephrine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 normetanephrine + S-adenosyl-L-methionine i.e. 3-methoxy-4-hydroxyphenylethanolamine Oryctolagus cuniculus metanephrine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 phenylethanolamine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus N-methylphenylethanolamine + S-adenosyl-L-homocysteine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.28 0.054
-
 epinephrine
-
 Oryctolagus cuniculus