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Literature summary extracted from

  • Lee, H.S.; Schulz, A.R.; Fuller, R.W.
    Isolation of multiple forms of rabbit-adrenal norepinephrine N-methyltransferase (1974), Arch. Biochem. Biophys., 163, 735-741.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.28 3,4-Dichlorophenylethanolamine substrate inhibition Oryctolagus cuniculus
2.1.1.28 3,4-dichlorophenylethylenediamine substrate inhibition Oryctolagus cuniculus
2.1.1.28 D-norepinephrine substrate inhibition Oryctolagus cuniculus
2.1.1.28 L-norepinephrine substrate inhibition Oryctolagus cuniculus
2.1.1.28 S-adenosyl-L-methionine substrate inhibition Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.28 0.00132
-
 3,4-Dichlorophenylethanolamine enzyme form H-2 Oryctolagus cuniculus
2.1.1.28 0.00159
-
 3,4-Dichlorophenylethanolamine enzyme form H-1 Oryctolagus cuniculus
2.1.1.28 0.00543
-
 S-adenosyl-L-methionine enzyme form H-1 Oryctolagus cuniculus
2.1.1.28 0.012
-
 3,4-dichlorophenylethylenediamine enzyme form H-2 Oryctolagus cuniculus
2.1.1.28 0.0131
-
 3,4-dichlorophenylethylenediamine enzyme form H-1 Oryctolagus cuniculus
2.1.1.28 0.0149
-
 S-adenosyl-L-methionine enzyme form H-2 Oryctolagus cuniculus
2.1.1.28 0.0297
-
 D-norepinephrine enzyme form H-1 Oryctolagus cuniculus
2.1.1.28 0.0299
-
 L-norepinephrine enzyme form H-2 Oryctolagus cuniculus
2.1.1.28 0.0428
-
 L-norepinephrine enzyme form H-1 Oryctolagus cuniculus
2.1.1.28 0.109
-
 D-norepinephrine enzyme form H-2 Oryctolagus cuniculus
2.1.1.28 0.226
-
 phenylethanolamine enzyme form H-2 Oryctolagus cuniculus
2.1.1.28 0.244
-
 phenylethanolamine enzyme form H-1 Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.28 37000
-
 gel filtration Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.28 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.28 enzyme form H-1 and H-2 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.28 adrenal gland
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.28 additional information
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.28 3,4-dichlorophenylethylenediamine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 D-norepinephrine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus epinephrine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 L-norepinephrine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus epinephrine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 phenylethanolamine + S-adenosyl-L-methionine
-
 Oryctolagus cuniculus N-methylphenylethanolamine + S-adenosyl-L-homocysteine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.28 0.0124
-
 S-adenosyl-L-methionine enzyme form H-2, substrate inhibition Oryctolagus cuniculus
2.1.1.28 0.0894
-
 S-adenosyl-L-methionine enzyme form H-1, substrate inhibition Oryctolagus cuniculus
2.1.1.28 0.109
-
 D-norepinephrine enzyme form H-2, substrate inhibition Oryctolagus cuniculus
2.1.1.28 0.165
-
 L-norepinephrine enzyme form H-1, substrate inhibition Oryctolagus cuniculus
2.1.1.28 0.508
-
 3,4-Dichlorophenylethanolamine enzyme form H-2, substrate inhibition Oryctolagus cuniculus
2.1.1.28 0.631
-
 L-norepinephrine enzyme form H-2, substrate inhibition Oryctolagus cuniculus
2.1.1.28 0.909
-
 3,4-Dichlorophenylethanolamine enzyme form H-1, substrate inhibition Oryctolagus cuniculus
2.1.1.28 1.138
-
 3,4-dichlorophenylethylenediamine enzyme form H-2, substrate inhibition Oryctolagus cuniculus
2.1.1.28 1.522
-
 3,4-dichlorophenylethylenediamine enzyme form H-1, substrate inhibition Oryctolagus cuniculus
2.1.1.28 8.298
-
 D-norepinephrine enzyme form H-1, substrate inhibition Oryctolagus cuniculus