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Literature summary extracted from
- Type II thyroxine 5'-deiodinase in the rat thymus (1995), J. Endocrinol., 146, 105-111.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.99.4 | dithiothreitol | high concentrations increase type II activity | Rattus sp. |  |
| 1.21.99.4 | isoproterenol | type II | Rattus sp. | |
| 1.21.99.4 | additional information | hypothyroidism enhances type II activity and decreases type I activity | Rattus sp. |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.99.4 | 6-Propyl-2-thiouracil | inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity | Rattus sp. | |
| 1.21.99.4 | ipanoic acid | type II | Rattus sp. | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.21.99.4 | 0.009 | - |
L-thyroxine | DTT 20 mM | Rattus sp. | |
| 1.21.99.4 | 0.009 | - |
L-thyroxine | type II, thymus | Rattus sp. | |
| 1.21.99.4 | 0.009 | - |
L-thyroxine | 0.0105 mM during hypothyroidism | Rattus sp. | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.21.99.4 | membrane | type II in membranes of stromal cells and thymocytes | Rattus sp. | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.21.99.4 | L-thyroxine + AH2 | Rattus sp. | thyronine 5'-deiodinase type II | 3,3',5-triiodothyronine + iodide + A + H+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.21.99.4 | Rattus sp. | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.21.99.4 | - |
Rattus sp. |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.21.99.4 | additional information | no type II activity in spleen | Rattus sp. | - |
| 1.21.99.4 | thymus | thyronine 5'-deiodinase type II | Rattus sp. | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.21.99.4 | L-thyroxine + AH2 | thyronine 5'-deiodinase type II | Rattus sp. | 3,3',5-triiodothyronine + iodide + A + H+ | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.21.99.4 | 37 | - |
- |
Rattus sp. |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.21.99.4 | 7 | - |
- |
Rattus sp. |
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