Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Garcia-Macias, J.F.; Molinero, P.; Guerrero, J.M.; Osuna, C.
    Expression of type II thyroxine 5'-deiodinase from rat harderian gland in Xenopus laevis oocytes (1994), FEBS Lett., 354, 110-112.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.4 isoproterenol type II Rattus sp.
1.21.99.4 additional information hypothyroidism enhances type II activity and decreases type I activity Rattus sp.

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.99.4 translation of purified rat RNA in Xenopus laevis oocytes Rattus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.4 6-Propyl-2-thiouracil inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity Rattus sp.
1.21.99.4 ipanoic acid type II Rattus sp.
1.21.99.4 propanolol type II Rattus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.4 0.001 0.005 L-thyroxine type II Rattus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2 Homo sapiens
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Homo sapiens
-
-
-
1.21.99.4 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 brain thyronine 5'-deiodinase type II Rattus sp.
-
1.21.99.4 brown adipose tissue thyronine 5'-deiodinase type II Rattus sp.
-
1.21.99.4 harderian gland thyronine 5'-deiodinase type II Rattus sp.
-
1.21.99.4 hypophysis thyronine 5'-deiodinase type II Rattus sp.
-
1.21.99.4 keratinocyte thyronine 5'-deiodinase type II Rattus sp.
-
1.21.99.4 kidney
-
 Rattus sp.
-
1.21.99.4 liver
-
 Homo sapiens
-
1.21.99.4 liver thyronine 5'-deiodinase type I Rattus sp.
-
1.21.99.4 pineal gland thyronine 5'-deiodinase type II Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Homo sapiens 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 iodothyronine 5'-deiodinase type II, no selenoprotein, induced by bt2cAMP and hydrocortisone (ED50 4nM) Rattus sp.