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Literature summary extracted from

  • Sharifi, J.; St.Germain, D.L.
    The cDNA for the type I iodothyroine 5'-deiodinase encodes an enzyme manifesting both high KM and low KM activity (1992), J. Biol. Chem., 267, 12539-12544.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.4 dithiothreitol high concentrations of cofactor increases type I activity Rattus sp.
1.21.99.4 additional information hypothyroidism enhances type II activity and decreases type I activity Rattus sp.
1.21.99.4 reduced thiols
-
 Rattus sp.

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.99.4 transcription in vitro, translation in Xenopus laevis oocytes Rattus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.4 6-Propyl-2-thiouracil inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity Rattus sp.
1.21.99.4 ipanoic acid
-
 Rattus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.4 0.1
-
 3,3',5'-triiodothyronine type I Rattus sp.
1.21.99.4 0.1
-
 3,3',5'-triiodothyronine DTT 20 mM Rattus sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.99.4 microsome
-
 Rattus sp.
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Rattus sp.
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.21.99.4 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type II, outer ring (phenolic) deiodination Rattus sp.
a
1.21.99.4 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type I, outer ring (phenolic) deiodination Rattus sp.
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 brain thyronine 5'-deiodinase type II Rattus sp.
-
1.21.99.4 brown adipose tissue thyronine 5'-deiodinase type II Rattus sp.
-
1.21.99.4 glial cell thyronine 5'-deiodinase type II Rattus sp.
-
1.21.99.4 hypophysis thyronine 5'-deiodinase type II Rattus sp.
-
1.21.99.4 kidney thyronine 5'-deiodinase type I Rattus sp.
-
1.21.99.4 liver thyronine 5'-deiodinase type I Rattus sp.
-
1.21.99.4 thyroid gland thyronine 5'-deiodinase type I Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 iodothyronine 5'-deiodinase type II, no selenoprotein, induced by bt2cAMP and hydrocortisone (ED50 4nM) Rattus sp.
1.21.99.4 iodothyronine 5'-deiodinase type I, selenoprotein, inducible by T3 (higher synthesis) and angiotensin II (positive chronotropic effect in myocard) Rattus sp.
1.21.99.4 iodothyronine 5'-deiodinase isoenzymes type I (D1) and type II (D2) Rattus sp.