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Literature summary extracted from

  • Visser, T.J.
    Deiodination of thyroid hormone and the role of glutathione (1980), Trends Biochem. Sci., 5, 222-224.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.4 EDTA
-
 Rattus sp.
1.21.99.4 reduced thiols e.g. dithiothreitol Rattus sp.
1.21.99.4 reduced thiols e.g. ethanethiol, glutathione Rattus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.4 2-Thiouracil
-
 Rattus sp.
1.21.99.4 6-Propyl-2-thiouracil inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity Rattus sp.
1.21.99.4 additional information 3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine Rattus sp.
1.21.99.4 SH-group blocking reagents
-
 Rattus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5-triiodothyronine + AH2 Rattus sp. isoenzyme type II and type III 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5-triiodothyronine + AH2 Rattus sp.
-
 3,5-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 Rattus sp. thyronine 5'-deiodinase type II 3,3',5-triiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 Rattus sp. idothyronine 5'-deiodinase type I 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Rattus sp.
-
 overview
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.21.99.4 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor reaction mechanism of thyronine 5'-deiodinase Rattus sp.
a
1.21.99.4 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type III, inner (tyrosyl) ring deiodination Rattus sp.
a
1.21.99.4 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type II, outer ring (phenolic) deiodination Rattus sp.
a
1.21.99.4 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type I, outer ring (phenolic) deiodination Rattus sp.
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 kidney
-
 Rattus sp.
-
1.21.99.4 liver
-
 Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5-triiodothyronine + AH2
-
 Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5-triiodothyronine + AH2 isoenzyme type II and type III Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5-triiodothyronine + AH2
-
 Rattus sp. 3,5-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 thyronine 5'-deiodinase type II Rattus sp. 3,3',5-triiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 thyronine 5-deiodinase type Rattus sp. 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 idothyronine 5'-deiodinase type I Rattus sp. 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 iodothyronine 5'-deiodinase iodothyronine 5'-deiodinase type Rattus sp.
1.21.99.4 iodothyronine 5-deiodinase iodothyronine 5-deiodinase type Rattus sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.99.4 8
-
-
 Rattus sp.

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.21.99.4 6.5 8
-
 Rattus sp.