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Literature summary extracted from

  • Koyama, S.; Yamaji, T.; Takematsu, H.; Kawano, T.; Kozutsumi, Y.; Suzuki, A.; Kawasaki, T.
    A naturally occurring 46-amino acid deletion of cytidine monophospho-N-acetylneuraminic acid hydroxylase leads to a change in the intracellular distribution of the protein (1996), Glycoconjugate J., 13, 353-358.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.18.2 expression in Cos-1 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.14.18.2 additional information naturally occuring truncated protein, lacking 46 amino acids in the middle of the normal full-length protein, causes a change in intracellular distribution of the enzyme from cytosol to endoplasmic reticulum and a loss in activity Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.18.2 cytosol full-length enzyme with normal enzymatic activity Mus musculus 5829
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1.14.18.2 endoplasmic reticulum naturally occuring truncated protein lacking 46 amino acids in the middle of the normal full-length protein Mus musculus 5783
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2 Mus musculus key enzyme for the expression of N-glycoloylneuraminic acid CMP-N-glycoloylneuraminate + NAD+ + H2O
-
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Organism

EC Number Organism UniProt Comment Textmining
1.14.18.2 Mus musculus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.2 liver
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Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2 key enzyme for the expression of N-glycoloylneuraminic acid Mus musculus CMP-N-glycoloylneuraminate + NAD+ + H2O
-
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